ID B0WNS6_CULQU Unreviewed; 755 AA.
AC B0WNS6;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=6041049 {ECO:0000313|EnsemblMetazoa:CPIJ008618-PA};
GN ORFNames=CpipJ_CPIJ008618 {ECO:0000313|EMBL:EDS31917.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS31917.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS31917.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ008618-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ008618-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; DS232014; EDS31917.1; -; Genomic_DNA.
DR RefSeq; XP_001850360.1; XM_001850308.1.
DR AlphaFoldDB; B0WNS6; -.
DR STRING; 7176.B0WNS6; -.
DR EnsemblMetazoa; CPIJ008618-RA; CPIJ008618-PA; CPIJ008618.
DR GeneID; 6041049; -.
DR KEGG; cqu:CpipJ_CPIJ008618; -.
DR VEuPathDB; VectorBase:CPIJ008618; -.
DR VEuPathDB; VectorBase:CQUJHB012324; -.
DR eggNOG; KOG0474; Eukaryota.
DR HOGENOM; CLU_003181_4_1_1; -.
DR InParanoid; B0WNS6; -.
DR OMA; MFMNPSP; -.
DR OrthoDB; 1089019at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03685; ClC_6_like; 1.
DR Gene3D; 3.10.580.20; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF166; H(+)_CL(-) EXCHANGE TRANSPORTER 7; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 142..163
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 254..278
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 290..314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 375..396
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 476..499
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 595..658
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 705..755
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 84219 MW; E0A63AE26B0FD1EC CRC64;
MSLKQQLVRD SDDADSDNEN GSSRLEYSVR IPADDEEQDR QENGPTFTVR QRKKKGQSPY
ESLDYDVCEN VLWQQEHRKI VPRFTVRKDF SRWIISMQIG IWTALVACAI NIVIDEVSRL
KYGFLKRAVD ENVLGGDLAI PYLWWVLLNV VPVLIGATLV AYVEPVAAGS GIPQVKCYLN
GVKVPRIVRI KTLAVKAVGV VTSVIGGLAG GKEGPMIHSG AVIAAGISQG KSTTLQKDMK
VFQYFRDDHE KRDFVVGGAA AGVAAAFGAP IGGILFSLEE AASFWNQSLI WRTFFASIIS
SFTLNVVLSA YHGLSSFRYR GLFNLGEFKP LPFEYYELPI FMLMGVLGGV SGAIWNSVNT
RINLFRARFV KYRWAKVMEA AFVAIIGATA ACAMAYSLND CRPLGNDPTE TPVQLFCEDN
EYNAAAALWF QTPEATVKAL FHDPPGSHTI LTLAVFVLIY YPLSCITYGL SVSLGIFIPT
LLVGAAWGRL FASFVVLAFP ASSVFMNPGK YALIGAAAQL GGIVRMTLSL SVILLETTGN
IAFVLPIIIT LMSAKWSGDY FNEGIYDTQI RTSKVPMLPW HVESRLENEL AENIMNAPVV
CVRKLEKVNY IIDILKNTTH NGFPVIESDE NDTREDGKLI GLILRSQLVV ILKRSMYVET
ERHWRDLVTI EQFRKEYPRY PTIDDLRISE DKTLKNYTVD MSTFMNPSPY SVNPDTSVPR
LFQLFRAVGL RHLVVVTQEN RVRGIITRKD FLKDD
//
