ID B0WP75_CULQU Unreviewed; 777 AA.
AC B0WP75;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 93.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDS32120.1, ECO:0000313|EnsemblMetazoa:CPIJ008897-PA};
GN Name=6041216 {ECO:0000313|EnsemblMetazoa:CPIJ008897-PA};
GN ORFNames=CpipJ_CPIJ008897 {ECO:0000313|EMBL:EDS32120.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS32120.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS32120.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ008897-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ008897-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; DS232020; EDS32120.1; -; Genomic_DNA.
DR RefSeq; XP_001850509.1; XM_001850457.1.
DR AlphaFoldDB; B0WP75; -.
DR STRING; 7176.B0WP75; -.
DR EnsemblMetazoa; CPIJ008897-RA; CPIJ008897-PA; CPIJ008897.
DR KEGG; cqu:CpipJ_CPIJ008897; -.
DR VEuPathDB; VectorBase:CPIJ008897; -.
DR VEuPathDB; VectorBase:CQUJHB004462; -.
DR eggNOG; KOG1453; Eukaryota.
DR HOGENOM; CLU_360266_0_0_1; -.
DR InParanoid; B0WP75; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR046987; Myo9.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46184:SF5; HEAVY CHAIN, UNCONVENTIONAL MYOSIN; 1.
DR PANTHER; PTHR46184; UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 131..180
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 225..419
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..771
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 83557 MW; 9D94C952C5208F55 CRC64;
MLGTRSHHAR SGRDRTVEGR HQQIPRELVV GGLGHERAPD QLDPRVERVQ DGRRVRCVRC
IVLIELNFDG VQGVHEAGVS NQHRVVHLLL PDVVRVALDS LRPGDVLLQR AEATLHDGDV
RIHCGRLLIP GHTFQLTIIN IATACEICQQ FLLWPIERGL VCQNCRLTCH KRCYLKSAAC
SKISNASPLG PGATVAGVGV TGVVSASGGG MCDDAAGLPT KLFGVPLTTL CAGSDGIKIP
AQIYSLIMMI EMHGLYSEGI YRKSGVSSKI KEVKAKMDRG MGGSDYEMDY ESYNVHVLTN
VLKSFLREMP EPLLTFDRYD DFLRAADLSD GNDRVHTLLS LIKKIPPAHH CLLERLIFHL
ALVAKLEQYN RMSASSLAIV FAPCVLRTNR YVPAQDSLND IGRQTKCMET LITQKMLNVK
STLADIDTLD TAAHTATTRL STLRSSKVFT QEEMAANARV GGGGHLETET EEMLLEGHIQ
EIKKEKALLT STLPSLARAS SDDDLLSTDL DGEGGSLDDL SSSKDKDLDT SGYNVISDSG
ISIRYQPPSE HGGEHQSIDY FHKVGKTKSL SHQTLVDREA FLKSGSQSGS ATTPQSPTTT
ITTSSSSPSS SSGVPSMIKS QNGSTSSVSN NSSTNTSKRS EQLNLSHSMV TLSTGVTGSH
AGPNFVSATS SSTSDLQRQK PIIMRSISGG YEPTSSLSSV NPSQKILIQQ SASIPITSSS
SCSLGNVNSA TAKDKEPKMN RRMSGSSRRQ SSGGGPPPSS QPPPPPPGNG DDEPIMV
//
