ID B0WQT6_CULQU Unreviewed; 3710 AA.
AC B0WQT6;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=Serrate protein {ECO:0000313|EMBL:EDS33016.1, ECO:0000313|EnsemblMetazoa:CPIJ009755-PA};
GN Name=6041871 {ECO:0000313|EnsemblMetazoa:CPIJ009755-PA};
GN ORFNames=CpipJ_CPIJ009755 {ECO:0000313|EMBL:EDS33016.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS33016.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS33016.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ009755-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ009755-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; DS232045; EDS33016.1; -; Genomic_DNA.
DR RefSeq; XP_001851070.1; XM_001851018.1.
DR STRING; 7176.B0WQT6; -.
DR EnsemblMetazoa; CPIJ009755-RA; CPIJ009755-PA; CPIJ009755.
DR KEGG; cqu:CpipJ_CPIJ009755; -.
DR VEuPathDB; VectorBase:CPIJ009755; -.
DR VEuPathDB; VectorBase:CQUJHB001399; -.
DR VEuPathDB; VectorBase:CQUJHB005031; -.
DR VEuPathDB; VectorBase:CQUJHB013957; -.
DR eggNOG; KOG1217; Eukaryota.
DR eggNOG; KOG3509; Eukaryota.
DR HOGENOM; CLU_000078_0_0_1; -.
DR InParanoid; B0WQT6; -.
DR OMA; ISCFCAG; -.
DR OrthoDB; 2877710at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00055; EGF_Lam; 4.
DR CDD; cd00096; Ig; 3.
DR CDD; cd00110; LamG; 3.
DR CDD; cd00112; LDLa; 5.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 4.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR13817:SF185; STRETCHIN-MLCK, ISOFORM U; 1.
DR PANTHER; PTHR13817; TITIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF13927; Ig_3; 10.
DR Pfam; PF00052; Laminin_B; 3.
DR Pfam; PF00053; Laminin_EGF; 6.
DR Pfam; PF02210; Laminin_G_2; 3.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00180; EGF_Lam; 5.
DR SMART; SM00409; IG; 13.
DR SMART; SM00408; IGc2; 13.
DR SMART; SM00281; LamB; 3.
DR SMART; SM00282; LamG; 3.
DR SMART; SM00192; LDLa; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 13.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01248; EGF_LAM_1; 3.
DR PROSITE; PS50027; EGF_LAM_2; 3.
DR PROSITE; PS50835; IG_LIKE; 13.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
DR PROSITE; PS51115; LAMININ_IVA; 3.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 299..373
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 523..606
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 659..844
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 899..952
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 946..984
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1026..1207
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1241..1290
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1299..1346
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1371..1541
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1571..1608
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1622..1711
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1721..1806
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1815..1904
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1913..1994
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2002..2088
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2093..2181
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2225..2306
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2316..2400
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2408..2487
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2502..2569
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2593..2671
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2679..2856
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2854..2890
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2892..2927
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2934..3109
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3143..3182
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3188..3371
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 2121..2145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2184..2231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2126..2142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2184..2208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2209..2228
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 44..56
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 51..69
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 63..78
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 113..128
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 404..416
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 411..429
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 423..438
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 443..455
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 450..468
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 462..477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 486..498
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 493..511
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 505..520
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 925..934
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 974..983
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1260..1269
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1299..1311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1317..1326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1598..1607
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2861..2878
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2880..2889
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2896..2906
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2917..2926
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3153..3170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3172..3181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3710 AA; 409830 MW; 71E2FBDDEC14224D CRC64;
MSSPALTEAV FPLNRSVMAY LIVSMAKMRK TVQQTHSPAR NDRCGPDSFE CHDGICIADY
KKCNGIVDCH DQSDELHCPY DFDVEDGEEE EEDNCTDDEF FCDGRCLDKR LQCDGRIDCQ
SGEDEENCPA LRAVHKTILK SCRGPDEMAS RAGRWTGLTL AVRCAGNRGV GVSVIASHPV
GLGSIPDGPD GIVRDEICLI TPSVGREVSD ALSMSSPATM AAASTLIGNV TGVRIATMEV
TSETVIITIP QQSAAHNTSV LMVPVLNIPS AVMVTETAEM VRMNTIVVPA QGRNSDVTPV
SAFRSPGGVT FGSIVPTVPT NTVACRDEGP IRAKVKWSRA NGLPLPPGSR DINGRLEIPN
IRFDHNGDYI CEAVGFPKST PGGSKMVHLI VERYYPAERP PSACSITQAT CMNGDCIAKS
QICDGNFDCV DGSDESGCRE SQCEPNEFRC SNKKCILKTW RCDGESDCGD GSDEENCATL
PPDAACRYDE FQCRSGQCIP KSFQCDSHPD CFDKSDEIGC MAPSVIQPPP PSLSIQAGGV
LNITCRATGI PVPLIVWRLN WGHVPSKCNS VSDNGFGVLT CNDMQLIDSG AYSCEIINSM
GTHFVSPDTI VVVSGNDTVC RNGYFNSKAR HPEECINCFC FGVSNQCKSA DLYTYALNPT
VSSLTVVGVE GPWTGQRRIT EGEFSNHDLT VTRHGVQLRL ANIVPGRQVP YYSLPVEYKG
NQLKSYGGSI RYQVEYDGTG NPNTAPDIIV KGNGIILLYK HNAPFYPDER NAVSATFLPG
TWRKDDNSLA SREDIMMVLA DVESILIKML YIEGVERNIE LLDIAMDSAA TQNLGLGSAT
LVEECRCPPG YRGLSCESCD FGYVRQSSGP WLGRCVPRAQ ECRPGYYGDP NRGIPCQPCP
CPVPGDKSRA RTCSLDNYNN VICNCDRGYT GDRCQQCAPG YVGNPMGDGC FPGQVTNCNS
EGTQQVLPDG RCICKTGVTG TYCDRCAAEH FYMHEKGCVE CFCMGISRSC TSTSLYRDTV
QATFNDGQSG FSLISDYANP EIIATNLPAS SREIVYRNFG TSDDTFYWRL PAKFLGNKLT
SYGGFLNYTL RYTPHSSGGA SRNNSPDVVL HSGNKIKLHH YRTDGSISPI GSSTYTVPIV
EDFWQNYEDG NKVLRPYLLM ALANVSDIFI KATYNTVSNE AALSHVGLDI ASENDYGSGT
RAWPVEQCQC SQGHIGLSCE DCGPGYYKGD GGLYLGLCEK CECNEHSDEC DPITGECLNC
RHNTYGSNCE HCKPPYVGNA TGGTPYDCTM DKPDSSFNCQ HCDPRGSTVR CEGQCECKRL
VEGYRCDQCR EGSFDLSAQN VDGCRECFCS GVTKSCSKSR FFREDLPLFI SGDDGFTLTD
RDGHVLVTDN FDVAPNRNEI SYNFRDRSTY YWSLPERLLG NQILSYGANL TITQSTVGSE
PSQDQDIILI GNGLKLFWTR PHYEDGTYSV PLLESYWKNV GSRGVYQASR SDLMTVLSKL
DHILVRATVR DYTTRSSISD IVLGTAVNVR TDYEPAEEVE VCRCPPGYRG TSCELCDDLY
YKDVFDRSAG ITGVCKPCPC DNADSCEADS RGDVICNCLP GFTGPNCDNR GHEDHVTERP
PPPVIEVVVT APTIQIVEVG SRIRLGCTAR YIVSKHPIDV RWDRIGGRLP DRAYIESGTL
TITNVQISDS GIYVCQAGSG PDTANQRVTV TVEGGSSSRK PEVSLSEDVI DRDEFRSADV
TCTATGFPTP IVTWERMDNH PLSSNVIIEY GLLRFNSLRK SDEGTYRCSA RNDIGESDKI
LHVYVRESRP SPTHPDHAYE TVVINPDNYQ GRSGEQITLT CVCQPRGQVR WAKTGEPDLP
RNSYIQNELL IIEHATAENS GRYTCTAIFP SGRERSSFVD VAVSPARPDF TSPRVKPLDN
KHAVTQGTDY TVICEASGNP QPTIKWTLSG KPFAPNVQQI GNTLRIVNAQ PANGGVYICL
AENSEGMDRS YTVLDIDRRE SPVLELYPTE PQVIKVGEST RLSCRATAGV PYPTLKWVRR
DRRPLSTRVT QDYPGVITLR EVTLDDAGEY ECRAENSAGS TSLSASIDVQ LAPIITITPP
VEELKIREGD ELSIQCTARG KPEPNVVIKP PHHQDTDPRH LSSYEGRGSA NVHIYQAEVK
HSGTYECIAT STAGTDSRFI TIQVDKKRGD LGPHDNDRDY EEPDRPIRPP PPYDNNRPHQ
PQPQPPYYDR PQQHTYKAIL GERSELLCNE ASRGARTEWR RADGRRLPAG SIPRDGQLII
ENTGHDATGL YDCVAHDIAA SPTTIVQIML QVIEPPRISF SPTMPMVVRS GETVTITCNA
TGEQPIHILW HGENMQYLPD RIRVSGQYLQ FTQITQEDAG RYYCSASNRH GNVTKVAEVI
VNRNEMIPDI PSHGRVHEVY RGSSISLDCK LPDNHYYPGL TYHWSRLDRP LPYNVRTEDR
VLQLNYIRDE DAGRYECRMN YPNGSVAYDF VDVVIKAPQS LPILRLEPTV SYLRPGESVV
VDCSSSAGSH VPVSWQRLGG QPLPYNFRQD GNRLIIQDVT ETDGGKYTCV CHTDDGLQYI
SDFELTVSPA RQPETQRTSK VEYAERGSTV KLQCNTDIHP TSFHWSRDRG TFNADQNITV
PILTLTDVQA ADAGTYICTA RHNGQSVDVL TILVVNGAIP FFPQSPKSFM AFNKIDNAYS
KFNFEISFKP EKLNGLILYN GQRRPNGDYI SVSLRNGFPQ FKFDFNGQLV SLQPEKPIHM
GQWHTIKVNR VRNNGFLLVD DQAPVVFPDK LKFHGLNLDD NLYIGGVPNF ANIPASAVEA
REGFVGCISR LVINGREIQL HQEAITNEGT TSCEPCADDP CKNSGVCLDT QSETGYSCVC
QDGYTGKDCR IEGQKCMPGT CGIGRCEETE NGAECYCPIH KTGPRCQYTE HYTDDTLAFK
DGSYAAYDKF QTKRSAKFRF KADNLEDGVL LYAVENEKTY GDFIAIILKD GYVELRYSVA
GKIPPVILKS TVPIRVNQWH DVSAGRSRGG LAYLQVDEEP LLNEPKIGRA TAIALKSNVY
VGGYDKSVLL NRAVSVSRGF EGCISNLEIS GNTLNMIDDI KDSANLYNCG HQQNSIDNGS
ENDEDNEIDP CKPGYGGPNC DVIVDVCLAQ RPCENGAVCH SKLNELQHTC ECQTGFLGRK
CENMYATNIG SQFRGDGFLE IDPKAIAASA DQYETKLAIM FSTTHYNGML LWYGQRNGDV
FSGDDYISLS VHEGFLELGM RLNGEESTLR NEDVFVADGE QHVAVITREA NRNRLEVDHF
SSHGETRPTR KQDIHLPGSI YIGGAPDLNR FTGDRFNESF NGCVYVIENP DTSRAVPLQD
FAIRTVNVDV CDDLISDQAD STAGGDSARQ QVVQSGDSFQ ADGFLALKSR HEEEKSINLQ
NEENFRRYAN PLKGSASSLR GAIELSLRPA PEINQIAAPN TLHRSVWLRR RRHRIIRRHP
RRDHGASLKD FGKWSINKCT AATPPATART GTHRRRRPAI PSCTTAIEAG LFCQMKRIDS
FEPSPVRGAC NGQFKKVNNE VAACCVLLPG YALLRYVCEI GETSLRYWKQ CFLLTSANRD
LRFLEQIGSK VCDSANRILF RMCLIISSPR ARNCSALLRQ VRNRVNISPA RDKNSGRRPR
WRTIAPIQEG TLSCPLEPYD DQLPARFRSY FAEEGGTLLL SSSFFSCSSR
//
