GenomeNet

Database: UniProt
Entry: B0WQV1
LinkDB: B0WQV1
Original site: B0WQV1 
ID   UBA5_CULQU              Reviewed;         397 AA.
AC   B0WQV1;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   16-JAN-2019, entry version 57.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5;
DE            Short=Ubiquitin-activating enzyme 5;
GN   ORFNames=CPIJ009416;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J.,
RA   Mauceli E., Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L.,
RA   Amedeo P., Antoine C.H., Arensburger P., Bidwell S.L., Crawford M.,
RA   Camaro F., Devon K., Engels R., Hammond M., Howarth C., Koehrsen M.,
RA   Lawson D., Montgomery P., Nene V., Nusbaum C., Puiu D.,
RA   Romero-Severson J., Severson D.W., Shumway M., Sisk P., Stolte C.,
RA   Zeng Q., Eisenstadt E., Fraser-Liggett C.M., Strausberg R.,
RA   Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: E1-like enzyme which activates UFM1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000305}.
DR   EMBL; DS232046; EDS33031.1; -; Genomic_DNA.
DR   RefSeq; XP_001851085.1; XM_001851033.1.
DR   ProteinModelPortal; B0WQV1; -.
DR   SMR; B0WQV1; -.
DR   STRING; 7176.CPIJ009416-PA; -.
DR   EnsemblMetazoa; CPIJ009416-RA; CPIJ009416-PA; CPIJ009416.
DR   GeneID; 6041892; -.
DR   KEGG; cqu:CpipJ_CPIJ009416; -.
DR   VectorBase; CPIJ009416-RA; CPIJ009416-PA; CPIJ009416.
DR   eggNOG; KOG2336; Eukaryota.
DR   eggNOG; COG0476; LUCA.
DR   HOGENOM; HOG000256352; -.
DR   InParanoid; B0WQV1; -.
DR   KO; K12164; -.
DR   OMA; ETHNYNI; -.
DR   OrthoDB; 1092362at2759; -.
DR   PhylomeDB; B0WQV1; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Ubl conjugation pathway; Zinc.
FT   CHAIN         1    397       Ubiquitin-like modifier-activating enzyme
FT                                5.
FT                                /FTId=PRO_0000391940.
FT   ACT_SITE    244    244       Glycyl thioester intermediate.
FT                                {ECO:0000250}.
FT   METAL       220    220       Zinc. {ECO:0000250}.
FT   METAL       223    223       Zinc. {ECO:0000250}.
FT   METAL       297    297       Zinc. {ECO:0000250}.
FT   METAL       302    302       Zinc. {ECO:0000250}.
FT   BINDING      77     77       ATP; via amide nitrogen. {ECO:0000250}.
FT   BINDING      98     98       ATP. {ECO:0000250}.
FT   BINDING     121    121       ATP. {ECO:0000250}.
FT   BINDING     144    144       ATP. {ECO:0000250}.
FT   BINDING     178    178       ATP. {ECO:0000250}.
SQ   SEQUENCE   397 AA;  43505 MW;  D68F55B599469634 CRC64;
     MTSVAELREQ VRSLQDELAQ LKGERGKTTT REKITKMSSE VVDSNPYSRL MALQRMGIVK
     EYEQIRQKSV AVVGVGGVGS VTADMLTRCG VGKLILFDYD KVELANMNRL FFTPDQAGLS
     KVEAAAKTLN YINPDVKIFT NNYNITTVES FEKFMNAIRT GGIDGSGAVD LVLSCVDNFE
     ARMAINAACN ELSLNWFESG VSENAVSGHI QFIQPGEKAC FACAPPLVVA ENIDEKTLKR
     EGVCAASLPT TMGIVAGMLV QNTLKYLLKF GTVSDYLGYN ALIDFFPKMG LKPNPTCDDR
     FCVLRQQEFA AKPKEETFEE VQQEEESPVH AENLYGIELV SETEVESAPT VPVATANTGL
     KLAFETPIQM EHSSAATDVI KNDDVSLDDL MAQMKAI
//
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