ID B0WS07_CULQU Unreviewed; 1178 AA.
AC B0WS07;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 94.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN Name=6042364 {ECO:0000313|EnsemblMetazoa:CPIJ010133-PA};
GN ORFNames=CpipJ_CPIJ010133 {ECO:0000313|EMBL:EDS33625.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS33625.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS33625.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ010133-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ010133-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005231}.
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DR EMBL; DS232063; EDS33625.1; -; Genomic_DNA.
DR RefSeq; XP_001851491.1; XM_001851439.1.
DR AlphaFoldDB; B0WS07; -.
DR STRING; 7176.B0WS07; -.
DR EnsemblMetazoa; CPIJ010133-RA; CPIJ010133-PA; CPIJ010133.
DR GeneID; 6042364; -.
DR KEGG; cqu:CpipJ_CPIJ010133; -.
DR VEuPathDB; VectorBase:CPIJ010133; -.
DR VEuPathDB; VectorBase:CQUJHB013064; -.
DR eggNOG; KOG0933; Eukaryota.
DR HOGENOM; CLU_001042_9_0_1; -.
DR InParanoid; B0WS07; -.
DR OMA; HNKIAME; -.
DR OrthoDB; 231904at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 518..638
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 432..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 982..1026
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1178 AA; 133175 MW; 6278D4D6DA47DAE1 CRC64;
MYIKSIIIDG FKSYGKRTEV HGFDPEFNAI TGLNGTGKSN ILDSICFVLG ISNLVHVRAT
SLQELVYKSG QAGVTKATVT LVFDNTDKDQ CPLGYEKCNE ISITRQIVVG GKNKYLINGK
TVQNKKVQDL FCSVQLNVNN PNFLIMQGRI TKVLNMKPQE ILSMIEEAAG TSVYEAKREH
SIKLIEKKDA KLNELYTVLR EEIEPKLEKL RKERAHYIEY QKVCRDIEYL TRLYVSHKYL
QFVKAVENSE KSIATLNDTI EANRKKIEGN CGECKEIEVG AKELQEKIDN EGGGVLAELE
AELSGESKKE ATVAAERNST KDNIGVEQRK LKNLLKSIKD DEGALGKKEG EMQRTGDMFQ
SLKDADEADA KAFADAQKRF EAVSAGLSTN EDGEAATLQD QLMAAKQKAA ESATAIKQSE
MELKHCQQLL KEKERDANSS DAAYTEDKKK LTKTEGQIRA LEAELQKIDY EEGSIEQLQE
RKQQLTHEIR NLRGELDRKN AYRWEFQYRD PEPNFDRSSV KGMVAKLISV RDRKYALGLG
TAAGGSLYSV VVDSDSTGKK LLQKGQLQTR TTMIPLNKIS GRSIDQNTVR VADSLVGKGR
AVTSLSCVEY DREIEPAMKF VFGGSFLAED MNVAKQVTYH RQIMCRSVTL DGDVVDPSGT
LSGGAKPKGG AVLLEVEEIN QIQRALAQKE QEYQQVCAEI SKLERVAARF GQLKEQLDLM
QYELKTLQAR LAQTTFQQAQ QEIEDLKQKV ETLQQTMVDA RQTQTAANAK VKDLTAKIAD
SKGYRERELK SAEDELKRAK KKSEESRKNW KKHEQGFETL KLEIEELQKG IASAREQATK
LEETIAELQE KLNSVSENSE AMVAAVQAVK QKIKEHKDKI NSQNKELKAK YHHRDKLLKQ
NEELELEIKK KENEIQKVRN DNKDGYNKIS GLEEKYPWIT EDKEFFGVKN TRYDYNKEDP
QEAGRKLNKL QDSKEKMSRN INQKAMVLLE REEEQYKEVM RRKQVVEDDK KKIQKIITDL
DEEKKKQLKV AWTEVNENFG SIFSTLLPGT QAQLVPPDGV NFMKGLEVKV GFNGMWKESL
TELSGGQRSL VALSLILAML KYKPAPLYIL DEVDAALDLS HTQNIGNMLK AHFTNSQFVI
VSLKDGMFNN ANVLFRTKFV DGMSGVTRTV NVAAMRKR
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