ID B0WSD1_CULQU Unreviewed; 475 AA.
AC B0WSD1;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Nuclear envelope integral membrane protein 1 {ECO:0008006|Google:ProtNLM};
GN Name=6042511 {ECO:0000313|EnsemblMetazoa:CPIJ009707-PA};
GN ORFNames=CpipJ_CPIJ009707 {ECO:0000313|EMBL:EDS33769.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS33769.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS33769.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ009707-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ009707-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000256|ARBA:ARBA00004575}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004575}; Nucleoplasmic side
CC {ECO:0000256|ARBA:ARBA00004575}.
CC -!- SIMILARITY: Belongs to the NEMP family.
CC {ECO:0000256|ARBA:ARBA00005748}.
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DR EMBL; DS232068; EDS33769.1; -; Genomic_DNA.
DR RefSeq; XP_001870667.1; XM_001870632.1.
DR AlphaFoldDB; B0WSD1; -.
DR EnsemblMetazoa; CPIJ009707-RA; CPIJ009707-PA; CPIJ009707.
DR GeneID; 6042511; -.
DR KEGG; cqu:CpipJ_CPIJ009707; -.
DR VEuPathDB; VectorBase:CPIJ009707; -.
DR VEuPathDB; VectorBase:CQUJHB007452; -.
DR eggNOG; KOG3817; Eukaryota.
DR HOGENOM; CLU_025225_2_0_1; -.
DR InParanoid; B0WSD1; -.
DR OMA; SPECKQW; -.
DR OrthoDB; 3091795at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019358; NEMP_fam.
DR PANTHER; PTHR13598:SF1; AT07567P-RELATED; 1.
DR PANTHER; PTHR13598; UNCHARACTERIZED; 1.
DR Pfam; PF10225; NEMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..475
FT /note="Nuclear envelope integral membrane protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014566957"
FT TRANSMEM 147..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 393..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 53909 MW; BF0F74EB1187492B CRC64;
MHLPPCLLVS LLLVLGTGSI CRAATQGVGV HYLEPDGVIA YKPDPNRIFR PGLRTYCYRG
KDKQLGRLFQ TIILNFECDH DDFSQYEGGN PEEVRAHHET EQSLFSFNFL SNSRKKVIKL
DPFNQSCIGV VSGEAYVVRL NLIRIDFWRI ILLAAGVFVF LSAAKLSDNA LFYYICGIFL
GVFASFLVVV YLTSKIFPRK PMMYGVMLGG WTLGIYFAQM LFDNLRLIFV TYQLYVFWYV
LVTGFISFVV CYRMGPPKNQ RSKDLIKWSL QLAAIGAIFF SSAYREATTG FCIALFVCYY
FPRTLLARVS SLYRRRFPPK RRLLTVEEFN EQGARETIKA LDELREFCSS PNCKQWNTVL
KLKDPVRFAS FMEGSSHLID DEILEYETSH FNVDISDDDD DEEQDEATPT ARYRKFAAQR
SATNGRVPAA AAGGTTSTPT TARPTIGGRS SRSRSRQPVP TAPPRNEIEL SDDED
//
