ID B0WSE9_CULQU Unreviewed; 3527 AA.
AC B0WSE9;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=Cadherin {ECO:0000313|EMBL:EDS33794.1, ECO:0000313|EnsemblMetazoa:CPIJ010084-PA};
GN Name=6042530 {ECO:0000313|EnsemblMetazoa:CPIJ010084-PA};
GN ORFNames=CpipJ_CPIJ010084 {ECO:0000313|EMBL:EDS33794.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS33794.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS33794.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ010084-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ010084-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; DS232069; EDS33794.1; -; Genomic_DNA.
DR RefSeq; XP_001870677.1; XM_001870642.1.
DR STRING; 7176.B0WSE9; -.
DR EnsemblMetazoa; CPIJ010084-RA; CPIJ010084-PA; CPIJ010084.
DR KEGG; cqu:CpipJ_CPIJ010084; -.
DR VEuPathDB; VectorBase:CPIJ010084; -.
DR VEuPathDB; VectorBase:CQUJHB007924; -.
DR eggNOG; KOG1219; Eukaryota.
DR HOGENOM; CLU_000042_0_0_1; -.
DR InParanoid; B0WSE9; -.
DR OMA; YSSLYYE; -.
DR OrthoDB; 2961370at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0001736; P:establishment of planar polarity; IEA:UniProt.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IEA:UniProt.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 23.
DR CDD; cd00054; EGF_CA; 5.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 23.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF445; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 21.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 23.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 23.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00232; CADHERIN_1; 9.
DR PROSITE; PS50268; CADHERIN_2; 23.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2991..3015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..96
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 97..195
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 196..301
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 302..406
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 407..504
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 505..631
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 632..731
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 732..836
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 837..937
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 938..1039
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1040..1146
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1147..1248
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1249..1351
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1352..1459
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1460..1559
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1560..1666
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1667..1767
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1768..1871
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1872..1975
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1976..2080
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2081..2185
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2186..2290
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2305..2405
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2574..2612
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2629..2813
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2821..2858
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2860..2897
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2898..2933
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2935..2971
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 3235..3269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3359..3446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3462..3527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3243..3264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3423..3446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3484..3527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2583..2600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2602..2611
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2848..2857
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2887..2896
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2961..2970
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3527 AA; 391524 MW; F7581A68C09893BF CRC64;
MCCVYLRRTL VLATDQDMGE NGRVTYSIKS GRGKAKKFRI DPDTGIIYAA KSFEVDTEYD
LLVKAEDNGV PKKSQQARVS IAVVDVPAKS ENAPVLKTID QHVEVTESDT PGFLVALIQA
MDYDGEQLWF DIVGGDERNE FYIGRDNGNV LLAKYLDWET QKEYNLTISI SDGVHVVYTQ
LYVSVIDIND HRPEFTESLY RVDISESIEE GTEVLQLHAT DADEDKKLFY SLHAARDPVS
LKLFRVDSVS GSIITAHKLD REALAEHVLI VIVKDQGTPA KRNYAKVIIT VHDHNDHAPE
FTSKIVQGKV YETATVGTRV VQVYAIDRDI GDNARITYSI VSGNIGNVFN IDPTMGVISV
AKDLDISALS EYMLQVKASD GGKPSLSSQI PVHVMINMAD NAPPRFTSVD PAAEIYENLP
IGTFVIHIEA RSTSSLQFEI ISGNVNDMFF INPSTGVITT KDILDYETNK FYNLTVLATN
MASANATCAV IINVLDRNDN VPYFEQQVYK GEVSEATPIG SLVLTLNELP PNVSQLLVNV
SLPLVIKAKD ADSGLNALLH YDILEVMPRR YFHIDSNTGA IKTIMHLDHE KIPFFSFHVK
VTDLGKPRLT SETTAEVRIA VNDVNDCAPA FTQKEYNVTL LLPTYENVAV IQVNATDEDS
SENSTLRYDI IEGNRDGVFV IDAGSGIITT RDVESIGSQY KLGVRVSDGK FSKVAYVNIQ
VETSENSGLI FQKSIYEGSI LENSTKITTV TVVNVLGSNL NEHIEFGILN PTDMFKIGLT
SGAIQTTGKK FDREVRDNYE LIVEARSQLP DREKPRVAHV IVNVTILDIN DNCPMFVNLP
YYAVVSVDDP RGSVITKVHA LDLDSFENGE VRYEMKRGHG ELFKVDRKTG EVTLKQTLEG
HNRDYELLIS AYDGGITPCS TDVTVHVKVI DKSMPVFSKQ FYSDTVAENI ELHSPLSVAI
QAESPLGRKL IYSIVKGNEL EEFAVDFNTG AIYVVDELDY EQRQSYELLI RATDSVSGVS
AEVPVSVLVQ DVNDCPPEIE QDSYNITVSE RAQFGTAILK VQAKDNDTGI NQVVTYALQT
DSKNTSEYFH MDATDGVIYL KKSLDHETLS HHHFTVIASD RGVPSLSSTA HVWVSVLDMN
DNPPKFEQPS YTCVLSEHAA RGQFVTVVSA SDPDYIDHDR LTYTIAQGNE LQTYDIDPIS
GIITLVNMQN FAEKHQSVLN VSVTDGVYTS FTRVKITILP ANLHNPAFEH MFYDVKVNEN
QLAGRLVTTV KATDKDFGEY GRLSYSIISD EIQEYFSIDK EKGEIVTKKR LDREQKKLYE
VPIMAVDAGG RAGFATVRVK VGDENDNAPV FLYREYKALI QGNLTVNTTF FRVKAIDEDD
NQNAVVKYSI FDSQNSGVKD LFGIDENTGG IYLKKSATQW ENQLFQFFIR ANDGGTPSLY
TDVPIDIYIM SSADNPPVFE KKEKLLFLSE SSLPGTVITR LKLSGNVTAS YRILSDELEE
PQFSINNAGE LRLAKTLDRE LKDVHLIAIL AETDPSPPLT AVTEVILHVQ DENDNTPIFE
SNPYSFVLAE NIEKGSSIMK LTARDSDSGS NGDIRYSLSA DVGDIVNIFD VDAYTGWITT
LVPLDKEKRE DYKFQVIATD NGQPKHATRT TVIIRLKDYN DCPPTFKESR YNSSVSEDAL
PGTVVLQIST TDKDVDLKTP IEYYIISGDP LSQFQIKNTG EVFVVKALDR ESISRYELGV
IVTDGKYTST TNISITVLDA NDNPPYCLKY RYREQLSEGV HPGTFVLQIQ ANDIDEPANS
RLRFYLTGNG AEDFNLDKDS GQLKTARQLD RETQSKYQLT AHVQDRDHPG WECSSQIVIV
VTDLNDNPPE FSLNPYSVTL PEDAEVGTLV TKIHATDADI GVNRKIKYSF IDSYRDHFRI
APDSGIVTLS KPLDREVKAL YNLTVRATDQ GKPSLFNSAF LIVNVQDIND NPPEFTSKHY
FASVPEINSV GSEILKVLAT SKDTGINAEI NYSIIGGNEH RKFAMNNRTG ILSLADTLDY
ERAKDYFLTI QAVDGGTPPL SNLATVNISV TDSNDNPPQF TQNSYTARIR EDAQKGDKIL
QVRANDMDAE ENGRVSYKIE RGDRMGQFAI EPETGYISVA GTLDRESISN YVLEVQARDN
GLPTLTAYVL VNIEISDAND NPPIFTIQNY TAVVQEDKQI GYTLLKFEVT DADSAPNAAP
YTFDFRSGND GGAFRIEQDG ILRTATRFNS KIKDSYQLQI RVFDNGAPPL YSDTWVSVKV
IEESQYPPVI TPLDISINSF LDEYPGGVIG KVFATDQDQY DTLTFGLAPT AGVLYSPTNL
FNISRNDGVL YAFPRLDVGD YRVNVTVSDG KFSSYTIVKV AVELVTDDML TNSIVIRFTK
VSPESFILSH RKGFIRSVRN SMGCKIKDII IISVQKSTDD INLIHHRFRR DLSNVTHLLE
SPRHRRGTIN DLDVLFTVRK GPTGYYSAYE IRKAIDDNLE EIEDATKLQI DEVVKSKCLP
NFCTHGECED KLVLDPKIVN PISTDVTSFV SARHIHKMEC NCKEGYGGDK CQHAVNECSK
APCPNYKNCV PDSSDQGYHC ICPEGFAGPK CDRDISKCND ETCYTPRNPV SFSGKSYAHY
RIEKEIAKKN LEDQLMLSLR IRTVQPTGNI MYSSGKVDYN ILEIVNGVIQ YRFDLGSGEG
MVSVTSIFVS DGLWHEVRLE REGNSARVIV DNKHVASGNA PGVNGVLNLQ SDDIYFGAEV
KQHPTVLGFE DIQRGYMGCM DDIKLSKIPV PLHMNGASSV ASLRRFANVE FSCDASAILV
PLGVCGTQPC WNGGTCTDIG GGNFECLCHS RFSGLFCKED LDPCASSPCL YGGKCSKLSP
GNYTCDCPAR MSGKRCDYGR FCTPNPCRNG GVCEEGDDGP LCMCRGYTGT TCEIDIDECE
QQPCGNGATC INEAGSFRCV CPPEMTGASC GDPLYTFPLR IPFNSVTSEQ WVLFAIALGG
LVILSLLIYG IVVVCRKKRR VHRHEKINND PKTMVLNSVS DNSQYKRSSK MSNLEIIQRD
MQQRPVSYTP SSNNDHPYTC NAMLQYNNLD TLRSYGSAGD ELENVPPEYR KASVRPNQQL
VNINSGNASS DTESLHKQKW VDQMQMQTFT DSKINNDLKR ISPISSLDSH RSHKQQQSGI
LQGRLLNMPH SPTLLQPPQL QMQQHSSFEE SPGLSVHGAY HWDCSDWVGR GHHPLPNITE
VPGSEVPDSS SFHSNESNES HPKNNLLPPI LGPVDPARDI ETLNEDNESE FVDDSECDQS
EQPLSLGFEQ NTSIPCLNPL DSGSEDYRFN TADSYLRHPN SYLPKYNIQS ETEGECAPLT
GGGGGGGPGG ASRKPLNGLE VGPHQLVESD EDEDGIQAYG FPVTKRRNRR EPSDIDMVLH
SGGESSSLLS HSRNLNSSNH SNSDLSTHLC EIDDSEFEQD LPTAMQHHQQ QPSHHHHHHH
HPTQQQLQPS QQHQSSSSLS SSGGSGQPPR PKQNKVKWAN SVQQTEV
//
