ID B0WU75_CULQU Unreviewed; 520 AA.
AC B0WU75;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Cytochrome P450 9b1 {ECO:0000313|EMBL:EDS34795.1};
GN Name=6043264 {ECO:0000313|EnsemblMetazoa:CPIJ010203-PA};
GN ORFNames=CpipJ_CPIJ010203 {ECO:0000313|EMBL:EDS34795.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS34795.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS34795.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ010203-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ010203-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- FUNCTION: May be involved in the metabolism of insect hormones and in
CC the breakdown of synthetic insecticides.
CC {ECO:0000256|ARBA:ARBA00003690}.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004174}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; DS232101; EDS34795.1; -; Genomic_DNA.
DR RefSeq; XP_001870910.1; XM_001870875.1.
DR AlphaFoldDB; B0WU75; -.
DR STRING; 7176.B0WU75; -.
DR EnsemblMetazoa; CPIJ010203-RA; CPIJ010203-PA; CPIJ010203.
DR GeneID; 6043264; -.
DR KEGG; cqu:CpipJ_CPIJ010203; -.
DR VEuPathDB; VectorBase:CPIJ010203; -.
DR VEuPathDB; VectorBase:CQUJHB016715; -.
DR eggNOG; KOG0158; Eukaryota.
DR HOGENOM; CLU_001570_5_2_1; -.
DR InParanoid; B0WU75; -.
DR OMA; WKGAQPE; -.
DR OrthoDB; 658605at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd11056; CYP6-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24292:SF104; CYP9F3-RELATED; 1.
DR PANTHER; PTHR24292; CYTOCHROME P450; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 520 AA; 59973 MW; 9C4B0FF4C9D77436 CRC64;
MELSYALGLS WLLTAVLLYK WITGSKDFFR NKPIPSVPFF SLRDNTYSLF LKQTDLGAFT
VHLYNKFAGA KIFGIFDTIK PVFVVRDPEL IKQITVKDFD HFVDRPALFG YSFRDDPYAL
FSKMLPVLHG ARWRNMRNIL SPAFTGSKMK QMFQLALGCC DNVVQFLNSV QQEQQHGEVE
MLLKDVTSRY GTDVISCCLF GRKLNSFQDR KNKFYTYGMD MIVLHRIVVV LKMFLIRCFP
ALAAKIKVDL LDRKHAKYFN AFVDETIEDR TRNNIKGNTL IDMMIEVQLH QQSQESVLPV
TFTNHEIVAQ LLTLFLAGSG TFQFSSVALI HDLIMNPDVQ QKLYEEILQT QSELGTEKLN
YDTIQNMKYM EMVTLESMRL HTSFSNAYRH CVKDYTVDDG NGLKFNIHQG SNVWIPILGL
HMDPKYFPDP KRFDPERFNA ENRPNIHPAT YIPFGAGPRN CVARRFGLMK VKALLYHLLL
NFSITASPNT PKVLPMNKAF AFLDTVDGDF PVTFKRRQKN
//
