ID   B0WWJ7_CULQU            Unreviewed;       666 AA.
AC   B0WWJ7;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=BEN domain-containing protein {ECO:0000259|PROSITE:PS51457};
GN   Name=6044231 {ECO:0000313|EnsemblMetazoa:CPIJ010955-PA};
GN   ORFNames=CpipJ_CPIJ010955 {ECO:0000313|EMBL:EDS36089.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS36089.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS36089.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ010955-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ010955-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; DS232149; EDS36089.1; -; Genomic_DNA.
DR   RefSeq; XP_001861769.1; XM_001861734.1.
DR   AlphaFoldDB; B0WWJ7; -.
DR   EnsemblMetazoa; CPIJ010955-RA; CPIJ010955-PA; CPIJ010955.
DR   KEGG; cqu:CpipJ_CPIJ010955; -.
DR   VEuPathDB; VectorBase:CPIJ010955; -.
DR   VEuPathDB; VectorBase:CQUJHB001374; -.
DR   eggNOG; ENOG502S4GE; Eukaryota.
DR   HOGENOM; CLU_418098_0_0_1; -.
DR   InParanoid; B0WWJ7; -.
DR   OMA; CKNERIM; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:InterPro.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:InterPro.
DR   Gene3D; 1.10.10.2590; BEN domain; 1.
DR   InterPro; IPR018379; BEN_domain.
DR   InterPro; IPR037496; BEND6-like.
DR   PANTHER; PTHR35346; BEN DOMAIN-CONTAINING PROTEIN 6; 1.
DR   PANTHER; PTHR35346:SF1; BEN DOMAIN-CONTAINING PROTEIN 6; 1.
DR   Pfam; PF10523; BEN; 1.
DR   SMART; SM01025; BEN; 1.
DR   PROSITE; PS51457; BEN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT   DOMAIN          505..604
FT                   /note="BEN"
FT                   /evidence="ECO:0000259|PROSITE:PS51457"
FT   REGION          182..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          421..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          627..666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..216
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        627..652
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   666 AA;  73724 MW;  5F5D1F99ED12BFCB CRC64;
     MATIQSSDIA MHYGQHFVPM NSNPIQGYTT SAPIQQYGRQ TPQQQHMGAS AKTIQAEKPT
     ILNHTLPTST QHPVLMKIET PAAHHVQQQQ QQIHQSKMWL LIEWEMPAGE PNTYSVIDSS
     ELILHGLGRG KETIHTGKTI FVKRGNKIQQ ATVVIISDDK QFIDTELSQL RKMAAENLHR
     ISVASQDQNH QISNGNHQSK RRRTDNQSHD DMEPVSPEYE PMPVQSHVAN WVNNCKPPER
     VISPSPSIMS MHVPVGPAVL RAPPPMTFDQ QTQTDAKFFP NEPQRTTTVV SPPELARILS
     LQESILAEQK SVRMENEYNR KMMFDMMEKL SSFAETLQQL TVKVESSTQR NEFKYEITEV
     KSPGIPPAAS YVVLGTGGEE SRDQASSVAE SYAQKSSAIL ETTADNLVID HIALQHDDSN
     MSFSQSRCSV KDDNASNTST PKNQSLNFSK RFSASALSLS NASVHSQHSN SPAASEANKR
     SAVKDVLKDW ADDDGGDDSE LTPIGPNNTM VKKQVLRAIN WNNYKAATRK LLMTLFTREK
     LASHTLTGRP SPAFMGDRAK PVKDKLDQTI ITDIIFIITR SCNVTEPMVR TAITTKCADE
     NKMSRMKVGR TPAASSQRTM TQFVKDTSSA ASAVNSGTAA PAAVATSTPA NSHPKRIKRE
     NKENVH
//