ID B0WX21_CULQU Unreviewed; 526 AA.
AC B0WX21;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=MADF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=6044422 {ECO:0000313|EnsemblMetazoa:CPIJ011743-PA};
GN ORFNames=CpipJ_CPIJ011743 {ECO:0000313|EMBL:EDS36282.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS36282.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS36282.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ011743-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ011743-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS232156; EDS36282.1; -; Genomic_DNA.
DR RefSeq; XP_001861943.1; XM_001861908.1.
DR AlphaFoldDB; B0WX21; -.
DR EnsemblMetazoa; CPIJ011743-RA; CPIJ011743-PA; CPIJ011743.
DR KEGG; cqu:CpipJ_CPIJ011743; -.
DR VEuPathDB; VectorBase:CPIJ011743; -.
DR VEuPathDB; VectorBase:CQUJHB002167; -.
DR VEuPathDB; VectorBase:CQUJHB004575; -.
DR eggNOG; ENOG502TB25; Eukaryota.
DR HOGENOM; CLU_518033_0_0_1; -.
DR InParanoid; B0WX21; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR InterPro; IPR006578; MADF-dom.
DR InterPro; IPR039353; TF_Adf1.
DR InterPro; IPR012934; Znf_AD.
DR PANTHER; PTHR12243:SF70; FI03846P-RELATED; 1.
DR PANTHER; PTHR12243; MADF DOMAIN TRANSCRIPTION FACTOR; 1.
DR Pfam; PF10545; MADF_DNA_bdg; 3.
DR Pfam; PF07776; zf-AD; 1.
DR SMART; SM00595; MADF; 3.
DR SMART; SM00868; zf-AD; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS51029; MADF; 2.
DR PROSITE; PS51915; ZAD; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01263};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU01263};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01263}.
FT DOMAIN 7..85
FT /note="ZAD"
FT /evidence="ECO:0000259|PROSITE:PS51915"
FT DOMAIN 199..281
FT /note="MADF"
FT /evidence="ECO:0000259|PROSITE:PS51029"
FT DOMAIN 425..516
FT /note="MADF"
FT /evidence="ECO:0000259|PROSITE:PS51029"
FT BINDING 9
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 12
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 58
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 61
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
SQ SEQUENCE 526 AA; 61227 MW; 21F2D4F229A9610C CRC64;
MEALPTYRCR LCLTVFSDSD RTQLRDIFRD DNGDHFGCKV RECTGVYVTR QNSLTTACTN
CIQTVHLIDE FRNLCRQSDR SFVRAAFDGV TGFGPARWES YSYHVRELRK LLEPQQEENV
AGGSGYLPET VFVKGQQGPA EVGFEWEDVE EMVAVKQEVV GSDDEDEVEE GLEEVVGSDD
DGAPRRKRNR VNWEVDPLTL AKAIHRLPVL WNAKQDGHRQ SYQRDRAWTQ LATETGLNKD
KLKKMWCSLN DMFHRKRWGS DASDVQLYQL LETMFSASIR RRSKFGLSNE TRAAMAKLSN
ANGENERMTL AQIFYKHEDI WNRTHPDFDK QTKWNNLATQ LNTTVDELKR HWKCFKDIYY
ARRRRLQTGE IKPTHQCLQD PFFLLLEKMW IKNARPAQRQ PVPLRTTANI SPAEVEPLPA
NNRMQLTQLI HDREVIWNRS HPDHPVLAKR DEAFDEVARE LGMSMPELKH HWRTLRSFYC
NRYLRMKRGQ IAPDHPLLHE PVYLMLRKIF GDESSGGGEE GECPKV
//
