ID   B0WYV9_CULQU            Unreviewed;       449 AA.
AC   B0WYV9;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=Plasminogen activator inhibitor 1 {ECO:0000313|EMBL:EDS37219.1};
GN   Name=6045186 {ECO:0000313|EnsemblMetazoa:CPIJ011718-PA};
GN   ORFNames=CpipJ_CPIJ011718 {ECO:0000313|EMBL:EDS37219.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1] {ECO:0000313|EMBL:EDS37219.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS37219.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:CPIJ011718-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ011718-PA};
RG   EnsemblMetazoa;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|RuleBase:RU000411}.
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DR   EMBL; DS232199; EDS37219.1; -; Genomic_DNA.
DR   RefSeq; XP_001862581.1; XM_001862546.1.
DR   AlphaFoldDB; B0WYV9; -.
DR   STRING; 7176.B0WYV9; -.
DR   MEROPS; I04.067; -.
DR   EnsemblMetazoa; CPIJ011718-RA; CPIJ011718-PA; CPIJ011718.
DR   KEGG; cqu:CpipJ_CPIJ011718; -.
DR   VEuPathDB; VectorBase:CPIJ011718; -.
DR   VEuPathDB; VectorBase:CQUJHB004085; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   HOGENOM; CLU_023330_0_1_1; -.
DR   InParanoid; B0WYV9; -.
DR   OMA; CPILPQT; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00172; serpin; 1.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461:SF211; ACCESSORY GLAND PROTEIN ACP76A-RELATED; 1.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT   DOMAIN          105..447
FT                   /note="Serpin"
FT                   /evidence="ECO:0000259|SMART:SM00093"
SQ   SEQUENCE   449 AA;  50779 MW;  345AA26357681362 CRC64;
     MFLCPSDNGY FFSPNDCGQT IAISSRFGPD AIMFPTEDSE LQTRSTQRQV AQQLGQVTSR
     PVVQKPLQMQ GPVRRPQPLE DNDYEDVPPA VLVDTVGYQA MEFALNLFKQ LLSNLIEVAS
     PAARAELFRA IRLYPEQLAK LIQSLDRISK STVNTIETAA ANFFARDSKV NQTYHQALKL
     RDVDVIPVDF SHPAQAARQA NNWVSEKTHR LINEILNPGS VNAYTRMVLA NSIFFKGKWK
     YTFIKTEPST FQATPNRKIS INSMFQLNKL RYGEKQFADG NGLRWVELPY EGDNLAMLVF
     LPLQPHRLQE ALRQLQPYDL ASIMAELHVP YINTKVNLRL PRFTLTDSVS LIPALQSLGV
     NAIFNDKDSL PYLSRDATLV SDVTQRSYLS VDEFGTKATS VASLSIVTLS ITPQFRDVKF
     DVDQPFALMI VDKQERYPVF IGQVYEPQE
//