ID B0WZI3_CULQU Unreviewed; 3017 AA.
AC B0WZI3;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=Bromodomain adjacent to zinc finger domain protein 2B {ECO:0008006|Google:ProtNLM};
GN Name=6045430 {ECO:0000313|EnsemblMetazoa:CPIJ012613-PA};
GN ORFNames=CpipJ_CPIJ012613 {ECO:0000313|EMBL:EDS37497.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS37497.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS37497.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ012613-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ012613-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR EMBL; DS232207; EDS37497.1; -; Genomic_DNA.
DR RefSeq; XP_001862805.1; XM_001862770.1.
DR STRING; 7176.B0WZI3; -.
DR EnsemblMetazoa; CPIJ012613-RA; CPIJ012613-PA; CPIJ012613.
DR KEGG; cqu:CpipJ_CPIJ012613; -.
DR VEuPathDB; VectorBase:CPIJ012613; -.
DR VEuPathDB; VectorBase:CQUJHB015599; -.
DR eggNOG; KOG1245; Eukaryota.
DR HOGENOM; CLU_000465_0_0_1; -.
DR InParanoid; B0WZI3; -.
DR OMA; KLGHECI; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd15545; PHD_BAZ2A_like; 1.
DR CDD; cd15489; PHD_SF; 1.
DR CDD; cd22249; UDM1_RNF168_RNF169-like; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028942; WHIM1_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF2; IP14655P-RELATED; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 2.
DR Pfam; PF15612; WHIM1; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 869..943
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1152..1219
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 2468..2518
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2522..2574
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2922..2992
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 779..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1700..1791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1881..1923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2321..2341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2383..2433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2576..2641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2653..2686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2748..2904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 822..849
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1382..1416
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1646..1673
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 299..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1426..1441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1509..1554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1700..1725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2322..2341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2408..2433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2591..2641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2748..2880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2881..2904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3017 AA; 322340 MW; DC78FCD3FF6D46B4 CRC64;
MDKDGDKKGG DKKGGQSGAG LGGAAGGPDP ASLLDAASLF AYWGRDPSAM AAAASNSALF
GSQFGMPGGL GGLMPNAAAA AAAAAAATGA SGSDRFQMGQ HPNTMAVAAS QAASLAGLHN
SWWSMAQLAA QDYFARLQAS GMAGQMPFPH GADLASAFPG GLGGLGAMGG AGAGGGAGSG
GAGGAGGGGG GGSNGKGGGG GKGKKRDRSS NSNSSNASST GGAGGGGGAG GANSVGGYKN
SSSPSVSQAA AAAAYKQSLY SQATLHKELM AITAAAAAAQ QSPSGNSGGG GGGGGGGGGS
SKSKSSSGGS NRGSSGGSSN DILSMTRGSS ASPSVNSSKS QGPSPSVTIS ASNMSGGNHL
QGMGGGGGGR SGKDGKGGGQ NMAADLGLSA SMNALNTLSQ FGNLDLSSPQ NVTATMNALA
ASSAKAKDYM SSGILNDPSS LLGVRLPPDT EIIKYTSSIV GGGPKGSNNS NNSGNSGGGG
SSRNRNKNKT APIEESSLFA QLHGMSTAKR ARMDPNDYSG GQGTTGTSGG TLTSGGGSGG
NNDRIEVIKL PPTITSNGVY NTGKGKDSMA DQINDWAGLN LSGKGSSAMA NSLAAAAAAV
AAEAQDDAPL NLSMKSSKSD SRASPAPSPA GSGSTPSANS LQSLSTITAA LGGSGGNDTP
RSRRKSNNKN RSSAAAAAAM ADAASSLAAA AGSASGANNN SSISSLLMAA GSGSGANAGN
GTQPAGGSSA SGGAAATTAG GNGSGANNHL AAQLGLNSSL SELLKISNYE EYDYAGLSGS
QFKEGRPRNL GRGVSKPKKN TVASLLAQSR AVGSKPLTAQ QLLTQEAEIE KLRQAMIEAS
QSMESTSNTN TDTESVAESG MSESEGEEQI NVKELRVPLE KGWRRETVIR GLTKNGQIKG
DVFYYPPQSL NKMKGMNQVQ LYLDQFKPKD LTRDNFSFSA KAIVGTFLQP APPPYATDGE
YIKMTDVEVA RRLEELKMFT RHTALGVEQR IEIAKQQQAL RDAKKMAKDE ISKNKEKARQ
AKEIERNERL EQQRKERELK NQQAMEAKRK REEELARQKA EEAARKQQER ERRRQHMTLI
KQLELRRKFE EKEKKKHQVI LDKLIQREKK LTMRKRDTSI LQELRKPQED TEIGDQPVLP
NLPRIPGLKL TGTGFADLLM VFEFLHNFGE TLGFSESTDM EALPTLQSLH SALTCENAIE
AEEELLSVMT HLLVCAIEDP GIPNPGRHTT LLGQTLRQAD ITHSNVSEIL RIYLYAVAHG
EVKQQSGISL ERERERHHLP TEEDIKTASD KNRQFYELLS ENLRYKLSEL LKDKPFVALN
PTTKVQILAM LCNDLLLNKA VCKQIEGSLE TQAQLKKERY LLDNKIRKYK MLVARKQRLE
QYEKAQAAAL EKSLQMKAAE EAKRAEEAAA AAAAAEGIVI APPTGEDNQA AQTQPQQTGE
EKTEGGEGEV LDATAPPTTD SAPAPAEVEQ NHKDETVLNP SQESLPPLNN GTITPMEDSP
IKAPPTPHQL EESKSKELSF SEMGEHAPGG DVDHSFSKSM TMHHEHAPSE RNDDDNSDLE
SEGTQLEEDE DAHLTAEEAQ RKYDKILETS FQNKSQLEFA LNQLRVKCFG QDRYWRRYWC
LPKCGGVYVE AMESAQPDVC KYECALEEAH ASQEAAKAEA AAAEEAAAAA AAEAVADAAD
EAEGIPRFIP TIADIVKRDR DKNKENKDAN EFPSHHIGGL EERKRKRSGR SKKKHDFFNQ
ECTNDSESQD VQDEDNSRTS FSNCEETRTD SQSEAEHAPA PVTPVAPPVI EEHPKPVIPP
PVPMVQEPPV PPPIMLGAAK KKREDDHLMD IEDSIPTAIL VQKGNNHDET KIVEVNNQIG
GVNLNSSRGP QEDNDVQLVQ EETPTITIPD DDTESGDQPL RETEQPAGLT TNGGGGGVGD
AGSNCDIKPK LENGEIGADE EMELGEIKSE ERIKKELNSD QPMDRWFSIV DKELPLASTE
CPLPSIKGTT PSSVARQVYT NITCREICQI QGNRWDIGNN IQFFSVPLEK MVEIHFKNES
ILSLSGLDED EMADVIAKKI KLEPALESDT KPTLIPKRES IDESQLDVKP DVKQEGEAEE
YGTFSLPAYM TLTLSNLTAY VQCDQFQPLQ MTPEEERQLE EVKARGTLAK PEVKHVPKDL
RHGWWKINDI EELNELIKSL NPRGVRERSL RQSLLESLQE SVNLSTPFPV AHPRAPITNW
TESEAWNAWN PAIARRVEIA LLDQIEAMED KVASASMQMK GWQVPQRDGD SDNGIVEDVS
IEMLRERIAG LESAIERRYL KPPLGINTTE AQMAVIAQQE AHHHATMNSS NCSNSSEDEN
IPKGLMSWRD AVERSVTTAQ LSMALYVLES CVAWDKSIMK ASQADVSNGL TPSTPSKNAK
KKKKENGTTA SASSSPLSTP KSPSSPSASS SNAARGALLA AKTHLLLQLR KNRLTPRTSL
SSSKKLLLQN CQFCQSGEQE DKLLLCDGCD RGYHTYCFKP RMDKIPDGDW YCFECKNKAT
GDRKCIVCGG LRPPPLGKMV YCELCPRAYH QDCYIPPMLK YPRGKWYCTN CIGKAPPKKK
PQRKPKEKSS NHNTSLNQSS LSNQSANQSL NSSHEEIPQQ TSATAPCPMT SPTSATTPCG
GVAALHTTTG TAATLGTTPL SPAHSVASTT TTTTTHEEPL STAATTAATA TNPADFSQMT
MPTPTPPAIA FPQYANLEGT PVSSVLNSFQ LPPPPSTATT FDAQQQHYQQ YYQSQQQQQQ
QYYPDYVPES QPPSSQSQPD SGAAAAVNTS MDNTASSLNA SSLGSNDDST TADHQPQEQH
GAAVPSTPTS GGYSPSGSTS YDEQHNSEKP QQPQHQELSS SEEQQPVPAP ALTSSSSSSS
SSHKKDKKDR DEAREQAKKE KKATKKLMKE LAPCKAVLEE MEVHEDSWPF LLPVNTKQFP
TYRKVIKNPM DLSTIKKRLQ DMVYKSRDDF IGDVRQIFDN CEMFNEDDSP VGTAGHGMRK
YFEQRWAELT EKHSGSS
//
