ID B0X0A0_CULQU Unreviewed; 399 AA.
AC B0X0A0;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE RecName: Full=Splicing factor 45 {ECO:0000256|PIRNR:PIRNR031066};
DE AltName: Full=RNA-binding motif protein 17 {ECO:0000256|PIRNR:PIRNR031066};
GN Name=6045769 {ECO:0000313|EnsemblMetazoa:CPIJ012520-PA};
GN ORFNames=CpipJ_CPIJ012520 {ECO:0000313|EMBL:EDS37975.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS37975.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS37975.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ012520-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ012520-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- FUNCTION: Splice factor that binds to the single-stranded 3'AG at the
CC exon/intron border and promotes its utilization in the second catalytic
CC step. Involved in the regulation of alternative splicing and the
CC utilization of cryptic splice sites. {ECO:0000256|PIRNR:PIRNR031066}.
CC -!- SUBUNIT: Associates with the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR031066}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR031066}.
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DR EMBL; DS232231; EDS37975.1; -; Genomic_DNA.
DR RefSeq; XP_001863072.1; XM_001863037.1.
DR AlphaFoldDB; B0X0A0; -.
DR STRING; 7176.B0X0A0; -.
DR EnsemblMetazoa; CPIJ012520-RA; CPIJ012520-PA; CPIJ012520.
DR GeneID; 6045769; -.
DR KEGG; cqu:CpipJ_CPIJ012520; -.
DR VEuPathDB; VectorBase:CPIJ012520; -.
DR VEuPathDB; VectorBase:CQUJHB003418; -.
DR eggNOG; KOG1996; Eukaryota.
DR HOGENOM; CLU_044888_0_1_1; -.
DR InParanoid; B0X0A0; -.
DR OMA; IMSKFGY; -.
DR OrthoDB; 1343740at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd12647; RRM_UHM_SPF45; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR040052; RBM17.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR034653; SPF45_RRM.
DR PANTHER; PTHR13288:SF8; SPLICING FACTOR 45; 1.
DR PANTHER; PTHR13288; SPLICING FACTOR 45 SPF45; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF031066; Splicing_factor_SPF45; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR031066};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR031066};
KW Nucleus {ECO:0000256|PIRNR:PIRNR031066};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PIRNR:PIRNR031066};
KW Spliceosome {ECO:0000256|PIRNR:PIRNR031066}.
FT DOMAIN 222..268
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT DOMAIN 305..390
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 153..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 43029 MW; 1FB7DA345400A499 CRC64;
MALYDDLDSK QGPDKVAGWS SGIKLLQSQL QAKKATQPII QPKQQLLRKM TPMVNLKAKK
ENVDLFGLGG GSSGGGPKSV STTTTVTVAS IPSASGSNAG DSYSWEVTDE YDPLWPNEYD
KLVKDRKAKD VPVQKAPQNN YGRNRREYKR GVHLNKNMGD DGPGGKKSGF AGRPTSDDED
EFQPGQQRAV GGAAIAPPAS LQESIAQIPE GSKIAPLTAY GGSSVAAKIM AKYGFKDGQG
LGKQEQGMSM ALQVEKTSKR GGRIVHEKDM PAPDVPSGGA GAGGQTAIPF QEEPSITEIM
KSPSKIVLLR NMVGPGDVDD DLEPEVKDEC HTKYGDVITV VINEIPNVVP EETVRIFVEF
KRMESAIKAV VDLNGRFFGG RQVRAGFYSQ EKFERMELL
//
