ID B0X370_CULQU Unreviewed; 1956 AA.
AC B0X370;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN Name=6046984 {ECO:0000313|EnsemblMetazoa:CPIJ013181-PA};
GN ORFNames=CpipJ_CPIJ013181 {ECO:0000313|EMBL:EDS39572.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS39572.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS39572.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ013181-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ013181-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
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DR EMBL; DS232310; EDS39572.1; -; Genomic_DNA.
DR RefSeq; XP_001864092.1; XM_001864057.1.
DR STRING; 7176.B0X370; -.
DR EnsemblMetazoa; CPIJ013181-RA; CPIJ013181-PA; CPIJ013181.
DR KEGG; cqu:CpipJ_CPIJ013181; -.
DR VEuPathDB; VectorBase:CPIJ013181; -.
DR VEuPathDB; VectorBase:CQUJHB004587; -.
DR eggNOG; KOG0987; Eukaryota.
DR HOGENOM; CLU_001055_0_0_1; -.
DR InParanoid; B0X370; -.
DR OMA; TEWICHT; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR046700; DUF6570.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR025476; Helitron_helicase-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR PANTHER; PTHR47642:SF2; PHD-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20209; DUF6570; 1.
DR Pfam; PF14214; Helitron_like_N; 1.
DR Pfam; PF05970; PIF1; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 327..456
FT /note="DUF6570"
FT /evidence="ECO:0000259|Pfam:PF20209"
FT DOMAIN 603..767
FT /note="Helitron helicase-like"
FT /evidence="ECO:0000259|Pfam:PF14214"
FT REGION 29..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 122..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1956 AA; 223422 MW; A56A8E5AA10C74A3 CRC64;
MERSFPESRP FYCFCSACSE ASSFYPDYRR VKVEPRSSSS SSTSRGEQQR RRATPAEESS
REEEQLQVFF TLVRTNKEEK LVRMSRHLAA KYLASHRKRK REEREKENRV VAPLRQAEET
IADRDEEGEQ EMEEEEEIKA PKPRRPAKTS AERVREFRQR KKLKAQEEAE RGGTVAAGNP
AATVNLEPMP GPSTGPVRFY PRPDPVQIPS GSGRGTFQAD SETFLGIVPT RSALNESSQV
SVPNSQETGT TATAGGKPDC AKADIAFHKK FTNNKLGDYC NVCERIWFSN DLRPITSDGG
RVLVEAGHFE SVAGFKVCQT CNNSLRNGKV PTLSTSNGFT YPEKPANLPP LDPITERLIA
PRLPFMQIRR LSHARGSYTI IGQIINVPVD VNEMVRMLPR QLEDDYAFNV CIKKQLIHKS
NYLQGYVKKS VVKAWLRYLI NTPLYKREGI VLDESLIEPD VPEGTDGEEM VELEVSEVVD
VPRDVPRIPQ QNDQIALDVL ETEAELFTGQ QQTVLWNEDM SLNIAPGQNR MPTSIVYDQY
AEELSFPGIY QGKIRSYRKG VRVTPYDKAT SETRRRDRRG AKPTHILYMG VKIMRLRVHD
GVSSSFRVQG TNNVTRAQLS DPQFMQSLIE RNFAWLKSIP NSALYWQIRE KDLFAMIRQL
GKPTVFLTMS ANETHWPELL KILYKLSDQE NRIDLTEPME QLTALQRAVL VSEDPVTCCL
YFNKLIEVIL LILGSKTHSP FGKYYVVDYF KRIEFQHRGS PHCHAVLWLA NDPKEPASEH
MPATLELINT ITSIRFEDLP TQTATKQVHR CTFTCTKRGE KRCRFNIPYW PMKEQRVLLP
LKADDSRRKE LKKRAEEMRD VLATMVFDTI EDYLAHCECT YEYYLDVVRA SLKQPTVFYK
RSMDEKELRT NPFNAWIADK LRSNMDLQFI VDEKKLCHYL VEYVNKSNRG VSGLHRELIL
MQEQNPEMDY GEMLKKISLK MLGAVEMCAQ EAAWFLLRLP MSEASKKVEF IPTAWPQDRT
RSRKHFKTMD AEGVGDDSTD VWNKNIIEKY EEREGLEDVC LAEFVAWYSQ ERGKKSYKKR
TQPRVLRWRG FGMSELTEYK RESVLLFLPF RNEVVDVLDH NKFLQLYDLH EEQLLAKRKE
YDCELNMEQT VEEYLRTIAN LEDGAENNAA TEKHDELVRT VIMQPNNDDF ELLPTRGLRS
VIKQRTNVLS KEAYCEMMRA TNAEQRALIL HVIHLMHCYE EHEPLQVFLT GPAGSGKTFV
LRALMETINR YSQTHNSRDN AYVASASTGK AASAIGGTTL HHAYHITMSR QAAKMNFETL
QMYRNEMQNI KFHIIDEVSM VGAHTLNTAH IRLQDVYMIY DVPYGGVNVL VSGDVMQLPP
VNARAVFKPP SNTICGAVVW QSLMFHELKR VMRQADKQFS DILTKIGNGL KLTADETKLI
ESRFFTKEDL SKEDTGGAVR LFHRNIDVTS YNNEALRNID GLDYTADDTF AGYKTAEQLA
TARIKLYKMS LAETAGLQYT TKFCPGMPYM VTTNVNVEDG IVNGAIGDLM YVEEGVDDSE
DRIMRLWIKF ENAQIGIIAR KEVEPMIRTR PDILQSDWTP IVKRSANIDL GNRIKCKRIQ
FPVTPANALT IHKSQGGTFD KIVYDYDKSQ DQQMVYVGLS RVKSLQGLFL TNSKGDFKFH
HAKGCDSPKM RELRNEYKRL QNNRLRTIVD EVGEVLESSG PATTLMTINV QSLRAHKLDI
TTDPILPKVH FLALSETWLD DHSSEEIEGF TCIIQSKRVG VRSGGVAIYQ NTTDPDTTLA
VPHTLEVVGN ERDQEFGKAE KYGDICAAKV MVMGTEVLLV SVYISPGTTT KQKIWFLARN
LIRTAYVDTP MVVTGDFNLD ITKEDSADFV GYMREHFMLS LCNDTKKTTT LGGTALDLTF
TKNMTAEVTR YTAYFSYHRP MLSLLRPAAS EPSQAI
//