ID B0X3V3_CULQU Unreviewed; 1137 AA.
AC B0X3V3;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=OSMotic avoidance abnormal family member {ECO:0000313|EMBL:EDS40030.1, ECO:0000313|EnsemblMetazoa:CPIJ014201-PA};
GN Name=6047241 {ECO:0000313|EnsemblMetazoa:CPIJ014201-PA};
GN ORFNames=CpipJ_CPIJ014201 {ECO:0000313|EMBL:EDS40030.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS40030.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS40030.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ014201-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ014201-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS232323; EDS40030.1; -; Genomic_DNA.
DR RefSeq; XP_001864325.1; XM_001864290.1.
DR AlphaFoldDB; B0X3V3; -.
DR STRING; 7176.B0X3V3; -.
DR EnsemblMetazoa; CPIJ014201-RA; CPIJ014201-PA; CPIJ014201.
DR KEGG; cqu:CpipJ_CPIJ014201; -.
DR VEuPathDB; VectorBase:CPIJ014201; -.
DR VEuPathDB; VectorBase:CQUJHB002199; -.
DR eggNOG; KOG3676; Eukaryota.
DR HOGENOM; CLU_004840_0_0_1; -.
DR InParanoid; B0X3V3; -.
DR OMA; FRELILM; -.
DR OrthoDB; 1003028at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0034703; C:cation channel complex; IEA:UniProt.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR PANTHER; PTHR10582:SF2; INACTIVE; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 558..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 173..205
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 231..263
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 516..657
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1034..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1093
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1137 AA; 127018 MW; E4A0DAC79A2B3006 CRC64;
MVKFDWRRMC RKKKNVPQGG AILDQVISQS TNVQGQCLLY KMANYKGGGD LIDAFKMGGQ
KAVEQLIREQ FGVFMYNAGR GQIINRAEYL RWKYMDNHEV VIPIEASLSP HDPLGKWVDH
KACWQMQYRG LLGESLLHVL IICDTKIHTK LSRILLRVFP ELSIDVMEGE EYLGASALHL
AIAYSNNELV GDLIDAGANV SQRAIGRFFL PRDQQKMHPA KTTDYEGLAY LGEYPLAWAA
CCSNESVYNL LLECGADPNA QDSFGNMILH MVVVCDKLDM FGYALRHPKL PCKNGIVNEA
GLTPLTLACR IGRDEVFREM LELSAREFWR YSNITCSGYP LNALDTLMPD GSTNWNSALF
IILNGTKEEH LNMLDGGIVE RLLDEKWKTF ARNQFLKRLL ILALHLFCLS CSIYLRPVHV
FKDDDDADDT DGVTDSPDTT DDEGIDLTTW FRYGFEVATV MGVLSYVVVQ QGEEIKNQGF
ISFLKSLAGA PAKAIFLISN LMILCCIPLR ILGDREAEEA VLLFAVPGSW FLLMFFAGAI
GLTGPFVTMI FSMITGDMFT FGIIYTIVLF GFSQAFYFLY KGHPNADESP FGTYFGTWMG
LFQTTLGDYD YADLNLTTYP NLAKTVFITF MIFVPILLLN MLIAMMGNTY AYVIEQAEKE
GMKQWAKIVV NLERAVKQED AKKYLEEYSI GLGPSDDPRF EIRGVMVIKS KSKTRARQRK
GAVSNWKSVL RVTLNELKKR SMTGEELRRI MWGRSSITSP AKISKKKKIY DEDEDPFAIT
AAIDVMSFTQ DIVMVSTEPV GPLMIDPTKP PVTTVKPTAP TVPSAQPAPG VPMTTAQTAA
PTAPQLVKRQ SVVSAPPAYD DFLPAKGFKD PLRELLILSE STSIDEHYAQ TCRSLATDAS
TLDHEEHQQQ QQQTVGQLNP FLDAKDVVDP VKEREFLKTL EALEDTDSEA AEKPVLGKIS
LIRRARSAVS RTTSRKKKTD QHPLFMIAWD DKTTTIPGGG PQAVSATAGT AAPEDDFGAL
NTAYECSAED LKHDVDEEAR EDDPDEGVTV EEVHRRMERF HQRPGRSSPE RDSNSTESSK
KQAKGDKRMK SAPSGHGPRH RQMMDTGGGS PPDPLEPWST KEIVPINKLL DTDTQDE
//
