ID B0X527_CULQU Unreviewed; 381 AA.
AC B0X527;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Sialic acid synthase {ECO:0000313|EMBL:EDS40673.1, ECO:0000313|EnsemblMetazoa:CPIJ013964-PA};
GN Name=6047730 {ECO:0000313|EnsemblMetazoa:CPIJ013964-PA};
GN ORFNames=CpipJ_CPIJ013964 {ECO:0000313|EMBL:EDS40673.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS40673.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS40673.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ013964-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ013964-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; DS232362; EDS40673.1; -; Genomic_DNA.
DR RefSeq; XP_001864749.1; XM_001864714.1.
DR AlphaFoldDB; B0X527; -.
DR STRING; 7176.B0X527; -.
DR EnsemblMetazoa; CPIJ013964-RA; CPIJ013964-PA; CPIJ013964.
DR GeneID; 6047730; -.
DR KEGG; cqu:CpipJ_CPIJ013964; -.
DR VEuPathDB; VectorBase:CPIJ013964; -.
DR VEuPathDB; VectorBase:CQUJHB008397; -.
DR eggNOG; ENOG502QR5J; Eukaryota.
DR HOGENOM; CLU_040465_1_0_1; -.
DR InParanoid; B0X527; -.
DR OMA; MTYIDYR; -.
DR OrthoDB; 3716025at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR CDD; cd11615; SAF_NeuB_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.90.1210.10; Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain; 1.
DR InterPro; IPR006190; AFP_Neu5c_C.
DR InterPro; IPR036732; AFP_Neu5c_C_sf.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR013132; Neu5Ac_N.
DR InterPro; IPR013974; SAF.
DR PANTHER; PTHR42966; N-ACETYLNEURAMINATE SYNTHASE; 1.
DR PANTHER; PTHR42966:SF1; SIALIC ACID SYNTHASE; 1.
DR Pfam; PF03102; NeuB; 1.
DR Pfam; PF08666; SAF; 1.
DR SMART; SM00858; SAF; 1.
DR SUPFAM; SSF51269; AFP III-like domain; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50844; AFP_LIKE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 320..379
FT /note="AFP-like"
FT /evidence="ECO:0000259|PROSITE:PS50844"
SQ SEQUENCE 381 AA; 41848 MW; 8640B3D49330C33F CRC64;
MKISGRDVGD GHPVFVVAEI GQNHQGSLEV AKRMIVKAKE LGADCVKFQK SCLAAKFTRN
ALRKPYSGDN SWGSTYGEHK AFLEFSLEDY KELQRFCAEQ DILFSASAMD PVSLQQLLEL
RVPFIKIGSG DADNVPMLRT AAAATSVPLI VSTGMQSWSQ VQNIYPIIKA HPSAALLHCI
SAYPTPPEQS LLNLVPLYKD HFPELVIGYS GHELGLQLSV ASVLAGARIV ERHFTLDKSW
KGTDHRASLD PEEFGRLVRY VRAVEGMNVE GERIVEVLSS VLEARDFNGE ELALALRSVT
GEDRKLLVSE VACHKKLGKS LVFAGDFAKG HKLREEDVAV KVSDPHGLSP TWYDQVVGRT
VARDCRQDEP ICGEDIAGCF G
//
