ID B0X6K4_CULQU Unreviewed; 687 AA.
AC B0X6K4;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Nesprin {ECO:0000313|EMBL:EDS41487.1, ECO:0000313|EnsemblMetazoa:CPIJ015328-PA};
GN Name=6048341 {ECO:0000313|EnsemblMetazoa:CPIJ015328-PA};
GN ORFNames=CpipJ_CPIJ015328 {ECO:0000313|EMBL:EDS41487.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS41487.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS41487.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ015328-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ015328-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR EMBL; DS232416; EDS41487.1; -; Genomic_DNA.
DR RefSeq; XP_001865276.1; XM_001865241.1.
DR AlphaFoldDB; B0X6K4; -.
DR STRING; 7176.B0X6K4; -.
DR EnsemblMetazoa; CPIJ015328-RA; CPIJ015328-PA; CPIJ015328.
DR KEGG; cqu:CpipJ_CPIJ015328; -.
DR VEuPathDB; VectorBase:CPIJ015328; -.
DR VEuPathDB; VectorBase:CQUJHB000060; -.
DR eggNOG; KOG0516; Eukaryota.
DR HOGENOM; CLU_400755_0_0_1; -.
DR InParanoid; B0X6K4; -.
DR OrthoDB; 5478539at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR47535:SF1; MUSCLE-SPECIFIC PROTEIN 300 KDA; 1.
DR PANTHER; PTHR47535; MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G; 1.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 2.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT TOPO_DOM 1..637
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TOPO_DOM 659..687
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 629..687
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
SQ SEQUENCE 687 AA; 79667 MW; A66E97EE848B68CB CRC64;
MSHAAKYNCL NEQHSYCITT AESRLVDIES RLRHWDKYNS IKSTLKQSIS YIEREKYSLQ
LVYISLKEIS KMQNKVNELQ MLFPQIEQDL DDMQRETSEI LSFTKDEHIM IQIRSDHGKL
SQQTAKLKES IETWIEFLSR IANLHEHFHS KCDQIHYNLV ELTRCLEDVK IDSLGASQHH
LNMLKNEQLR LVGIKDTLTT TNEIRDELKQ PLSHGKSITA KEAYQYQLES ALVEARGHLE
NLHTAINEIN VNNFMTSTQK VSKVSATCES SIELIKHLNL MVLSETQSDE EDTMNKLVTI
ECDKFTQYQT EWRSKQQKLE ELRSFPIAYN FICVHNDDYL TCPLCTNRNW QQIDNDLWRL
EQWLQMAEAN QKSQHTNPPT DIDTLEDTIQ DHREFLLDLD SHKSIIKSLN IVGEHLATHT
LDTEKAVRLR ERLQADNQRW EKVCSLASHW QSQLHHALMD NKEFHRTVTE LCAWLEQTEN
KIKSSEPIDL TSDMKLIERK YKTFRELRSD LVRCEPRVVS LQETTSQLTK YLEANKSQQF
DEIYAKLTDL RLRFHSIRRL VEMYTIKIAA ALGYDPTFDT NSIASVDTLP GIQGVSGSLT
RVAGQESNAN AQEGEDDEHI NTTVLTRSYR FLGRVVRASL PIQAMLLLLL GVVTLMPHGE
DYSCTLTNNF ARSLEPMLRY PNGPPPI
//
