ID B0X6V2_CULQU Unreviewed; 1055 AA.
AC B0X6V2;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Glutamate receptor {ECO:0000313|EMBL:EDS41623.1, ECO:0000313|EnsemblMetazoa:CPIJ013901-PA};
GN Name=6048455 {ECO:0000313|EnsemblMetazoa:CPIJ013901-PA};
GN ORFNames=CpipJ_CPIJ013901 {ECO:0000313|EMBL:EDS41623.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS41623.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS41623.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ013901-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ013901-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; DS232425; EDS41623.1; -; Genomic_DNA.
DR RefSeq; XP_001865374.1; XM_001865339.1.
DR AlphaFoldDB; B0X6V2; -.
DR STRING; 7176.B0X6V2; -.
DR EnsemblMetazoa; CPIJ013901-RA; CPIJ013901-PA; CPIJ013901.
DR KEGG; cqu:CpipJ_CPIJ013901; -.
DR VEuPathDB; VectorBase:CPIJ013901; -.
DR VEuPathDB; VectorBase:CQUJHB010316; -.
DR eggNOG; KOG1053; Eukaryota.
DR eggNOG; KOG1054; Eukaryota.
DR HOGENOM; CLU_002039_3_0_1; -.
DR InParanoid; B0X6V2; -.
DR OMA; DANCALM; -.
DR OrthoDB; 1034721at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR CDD; cd13718; PBP2_iGluR_NMDA_Nr2; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF391; NMDA RECEPTOR 2, ISOFORM C; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EDS41623.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 634..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 893..918
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 516..873
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 520..578
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 1055 AA; 119701 MW; F876EC7DD0706D18 CRC64;
MRKIPYKNSG LLKIREEVRK SVWFCFHDRR PEFKALFNGT EPKIFYGNDC VLPGHRHRKF
VCQVGARPSL ADMIDDFKWK ECPTPGRDGS FLGADFCDVG ARKLAKTSAA YGRRLGNPAS
SKNAGTKDHG CVSILNTLCK EFLHANVSAI LYMMNYESYG RSTASAQYFL QLAGYLGIPV
ISWNADNSGL ERRASQSALQ LQLAPSIEHQ SAAMLSILER YKWHQFSVVT SQIAGHDDFV
QAVREQVAAM DHFKFTILNS IIVSRPINLV ELVNSEARVM LLYCTKDEAV DILKAAEELH
ITGENYVWVV TQSVIENMQA PTQFPMGMLG VHFDTSSSAL LNEISNAIRV YAYGVEYYLS
DPKNAGRGLD THFLSCEDEG RGRWDNGEVF FKYLRNVSLE GEPNRPNIEF TADGDLKWAE
LKIMNLRPSV NSKGLVWEEI GMWKSWQQQK LDIRDIAWPG NSHTPPQGVP EKFHLKITFL
EEAPYINLSP ADPVSGKCLM DRGVLCRVAA DHEMTDIDMG QAHKNGSFYQ CCSGFCIDLL
EKFAEELGFT YELVRVEDGK WGTLENGKWN GLIHELVNRK TDMVLTSLMI NAEREAVADF
SEPFMETGIA IVVAKRTGII SPTAFLEPFD TASWMLVGIF AIQAATFMIF LFEWLSPSGY
DMKTVLQNAN NTPYRFSLFR TYWLVWAVLF QAAVHVDSPR GFTSRFMTNV WAMFAVVFLA
IYTANLAAFM ITREEFHEFT GLDDTRLSHP FSHKPTIKFG TIPWSHTDST ISKYFKEMHY
YMKQYNKTSV ADGVAAVLNG QMDAFIYDGT VLDYLVQQDE DCRLLTVGQW YAMTGYGLAF
SRNSKYVQMF NKRLLEFRAN GDLERLRRYW MTGTCRPGKQ EHKSSDPLAL EQFLSAFLLL
MAGILLAALL LLLEHLYFKY FRKRLAKKDR GGCCALISLS MGKSLTFRGA VYEATEIIRR
HRCSDPICDT HLWKVKHELD MTRLRNTQLE KALDAHGIKP PQIKMASTND IIGAGRREQF
ANRPGVLGNL SIGGSAQDLY RWTYKTEIAE METVL
//
