ID B0X9T0_CULQU Unreviewed; 853 AA.
AC B0X9T0;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=Pre-mRNA-splicing helicase BRR2 {ECO:0000313|EMBL:EDS43282.1, ECO:0000313|EnsemblMetazoa:CPIJ016208-PA};
GN Name=6049681 {ECO:0000313|EnsemblMetazoa:CPIJ016208-PA};
GN ORFNames=CpipJ_CPIJ016208 {ECO:0000313|EMBL:EDS43282.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS43282.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS43282.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ016208-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ016208-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; DS232548; EDS43282.1; -; Genomic_DNA.
DR RefSeq; XP_001866402.1; XM_001866367.1.
DR AlphaFoldDB; B0X9T0; -.
DR STRING; 7176.B0X9T0; -.
DR EnsemblMetazoa; CPIJ016208-RA; CPIJ016208-PA; CPIJ016208.
DR KEGG; cqu:CpipJ_CPIJ016208; -.
DR VEuPathDB; VectorBase:CPIJ016208; -.
DR VEuPathDB; VectorBase:CQUJHB004289; -.
DR eggNOG; KOG0951; Eukaryota.
DR HOGENOM; CLU_000335_0_3_1; -.
DR InParanoid; B0X9T0; -.
DR OMA; ICVMSSS; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0034641; P:cellular nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0010467; P:gene expression; IEA:UniProt.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EDS43282.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 320..495
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 853 AA; 98471 MW; CAD3FD5289335614 CRC64;
MIKKYPASTR LPRQLGANLW KSGLIKYDRK SDHFQVTRIG RMSGEFRNIA VREEETLELQ
KLMERVPIPI KESMEEPSAK VNVFLQAYIS QLKLEGFALM ADMVYVTQSA SRLLRWLHLA
PNKIWHLGKA AHDGIDRRMW QSMSPLRLFR KMPEEIVKKI EKKNFPWERL YDLEANEIGE
LIRVPKLDKT IYKYVHQFPK LELSTHIQPI TLRVELTIPP DFQWDEKVHG QSEAFWILVE
DVDSEVILHY EYFLLKYKYC QDDHLVKFFV PVFEPLPPQY FLRIVSDREE PAADGAARFA
AAANLYAFSQ FNPIQTQVFN AVYNNEDNVF VGAPTGSGKT RIAEFAVLRK LQQNPHGRVL
YLVSRDALAE LIFMDWHQKF GQNLGCKVVK LTGETGTDLK LIAKGQIIVT TADKWNILSR
RWKQRKNVQN IQLFIVDELQ LISGEEGPVL EVVCSRMRYI SSQIEKQIRI IALVRPIPLE
LHVQGFNITH NASRIAAMSK PMYNAVTKFS PHKPVIVFVN SRKLARLPAI DIFTYCAAEA
QPNRFFHAEE ADIKPFLDRM TDKTLKETLS QGVAYIHEGL AASDHRIVEQ LFDSGAVQIA
VVTRDLCWGL NIFAYLVIIM DTQFCNGKSH SYDVYPVTDV MQMVGRANRP LEDDDAKCVL
MCQSSKKDFF KKFLNESLPV ESHLDHRMRD HFNAEIVTKT IENKQDAVDY LTWTFLYRRL
TQNPNYYNLQ GVTHRHLSDH LSDLFESTRS DLEQSICISV EDEMDTLPLN LDMIAALLEI
IFEDNILAAQ LPNKLTGPNE TAHKYIDLHI KTNLQLQAHL FSIQQIRCIA AASMPTKPLE
DHILFTNNTR RQP
//
