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Database: UniProt
Entry: B0XBK2_CULQU
LinkDB: B0XBK2_CULQU
Original site: B0XBK2_CULQU 
ID   B0XBK2_CULQU            Unreviewed;      1198 AA.
AC   B0XBK2;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   05-JUN-2019, entry version 78.
DE   RecName: Full=Ubiquitinyl hydrolase 1 {ECO:0000256|SAAS:SAAS01044305};
DE            EC=3.4.19.12 {ECO:0000256|SAAS:SAAS01044305};
GN   Name=6050403 {ECO:0000313|VectorBase:CPIJ016898-PA};
GN   ORFNames=CpipJ_CPIJ016898 {ECO:0000313|EMBL:EDS44314.1};
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176 {ECO:0000313|Proteomes:UP000002320};
RN   [1] {ECO:0000313|EMBL:EDS44314.1, ECO:0000313|VectorBase:CPIJ016898-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|EMBL:EDS44314.1,
RC   ECO:0000313|VectorBase:CPIJ016898-PA};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA   Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002320}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB {ECO:0000313|Proteomes:UP000002320};
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J.,
RA   Mauceli E., Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L.,
RA   Amedeo P., Antoine C.H., Arensburger P., Bidwell S.L., Crawford M.,
RA   Camaro F., Devon K., Engels R., Hammond M., Howarth C., Koehrsen M.,
RA   Lawson D., Montgomery P., Nene V., Nusbaum C., Puiu D.,
RA   Romero-Severson J., Severson D.W., Shumway M., Sisk P., Stolte C.,
RA   Zeng Q., Eisenstadt E., Fraser-Liggett C.M., Strausberg R.,
RA   Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|VectorBase:CPIJ016898-PA}
RP   IDENTIFICATION.
RC   STRAIN=JHB {ECO:0000313|VectorBase:CPIJ016898-PA};
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide,
CC         peptide and isopeptide bonds formed by the C-terminal Gly of
CC         ubiquitin (a 76-residue protein attached to proteins as an
CC         intracellular targeting signal).; EC=3.4.19.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01117307};
CC   -!- SIMILARITY: Belongs to the peptidase C19 family.
CC       {ECO:0000256|SAAS:SAAS01045498}.
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DR   EMBL; DS232639; EDS44314.1; -; Genomic_DNA.
DR   RefSeq; XP_001867024.1; XM_001866989.1.
DR   STRING; 7176.CPIJ016898-PA; -.
DR   MEROPS; C19.A26; -.
DR   EnsemblMetazoa; CPIJ016898-RA; CPIJ016898-PA; CPIJ016898.
DR   GeneID; 6050403; -.
DR   KEGG; cqu:CpipJ_CPIJ016898; -.
DR   VectorBase; CPIJ016898-RA; CPIJ016898-PA; CPIJ016898.
DR   eggNOG; KOG1870; Eukaryota.
DR   eggNOG; COG5560; LUCA.
DR   HOGENOM; HOG000286031; -.
DR   InParanoid; B0XBK2; -.
DR   KO; K11848; -.
DR   OMA; VSEVWHR; -.
DR   OrthoDB; 147564at2759; -.
DR   PhylomeDB; B0XBK2; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0004843; F:thiol-dependent ubiquitin-specific protease activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016579; P:protein deubiquitination; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR035927; DUSP-like_sf.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR006615; Pept_C19_DUSP.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   Pfam; PF06337; DUSP; 1.
DR   Pfam; PF00443; UCH; 1.
DR   Pfam; PF02148; zf-UBP; 1.
DR   SMART; SM00695; DUSP; 2.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF143791; SSF143791; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS51283; DUSP; 2.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002320};
KW   Hydrolase {ECO:0000256|SAAS:SAAS01044238};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01044152};
KW   Protease {ECO:0000256|SAAS:SAAS01044292};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW   Thiol protease {ECO:0000256|SAAS:SAAS01044269};
KW   Ubl conjugation pathway {ECO:0000256|SAAS:SAAS01044331};
KW   Zinc {ECO:0000256|SAAS:SAAS01044373};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS01044352}.
FT   DOMAIN       28     93       UBP-type. {ECO:0000259|PROSITE:PS50271}.
FT   DOMAIN      162    658       USP. {ECO:0000259|PROSITE:PS50235}.
FT   DOMAIN      589    711       DUSP. {ECO:0000259|PROSITE:PS51283}.
FT   DOMAIN      720    825       DUSP. {ECO:0000259|PROSITE:PS51283}.
FT   ZN_FING      28     93       UBP-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00502}.
FT   REGION      272    398       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B0XBK2}.
FT   REGION      446    471       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B0XBK2}.
FT   REGION      823   1050       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B0XBK2}.
FT   REGION     1074   1152       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B0XBK2}.
FT   COMPBIAS    299    385       Polar. {ECO:0000256|MobiDB-lite:B0XBK2}.
FT   COMPBIAS    451    467       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                B0XBK2}.
FT   COMPBIAS    858    872       Polar. {ECO:0000256|MobiDB-lite:B0XBK2}.
FT   COMPBIAS    878    896       Polar. {ECO:0000256|MobiDB-lite:B0XBK2}.
FT   COMPBIAS    911    927       Polar. {ECO:0000256|MobiDB-lite:B0XBK2}.
FT   COMPBIAS   1028   1050       Polar. {ECO:0000256|MobiDB-lite:B0XBK2}.
FT   COMPBIAS   1074   1091       Polar. {ECO:0000256|MobiDB-lite:B0XBK2}.
SQ   SEQUENCE   1198 AA;  131231 MW;  851D8FD8AB34F6E7 CRC64;
     MKILPFEITF AKCDAWDRNF ELAPSIGEPC SECEANGPNL WICLQKNCLH IGCSEQYNDH
     STTHYQQQRS HCIHMNLSSQ RIWCYLCEFE VFLVQQQQQQ QQLRRTSVVS NDSSDASRYS
     ATANEKLLMY GGGGGGGGGG ESCDSSCEED EFEKHGKWNG LVGLQNIANT CYMNSAIQAL
     SNSPPLTGYF LDCGSIIETD LLGNQTVSKP GLAKHYHKLI KEMWCKNRRY VVPSGILYGI
     RIVHPMFRGY QQHDTQEFLR CFMDQLHEEL KEVTQQQPPD LLSLQDRNGD PDISPCPSPS
     PSQSEAEYET CDSGVSEQSS LSDDVSINSK RTRMVSRSPS PGQRPVQSPH SRQQSPIGSN
     RSNSSSSGSM TSQQQQNQQP NDSQQKQKQT KDKLPERSII SDIFDGKLLS SVQCLTCDRV
     STREETFQDL SLPIPGKDHL AVLHQNHPGM QASPPPHPHP HPHPPPTAGS STGITCSDAV
     YPVSGDSWMW WFWNWPFWSW IRSWFWGPAV SLHDCMAAFF SADELKGDNM YSCEKCNKLR
     NGVKYSRVLA LPEMLCVHLK RFRHDLSYSS KISSPVHFPL NGLDMRPYLH KDCKSEVTSY
     DLCAVICHHG TVGGGHYTSF AKHDPTGKWF EFDDQLVTHV SPEDVQNCEA FNTFAEPGPI
     DNWTLLCPHG AFPPNKAPYF AKLVVPIPQP LWDFLYKKFG GGPVCNHIFP CHICKKAAES
     LSRRQRAELE AFTACNDEYQ YNETPTTIYA ISMAWFRQWQ LFARGVTTDE PGPIDNKTVA
     VPGDTAVPLR SVRQGSDYAQ INSTLWHFFH GIYGGGPEIV LRGNPVPPPE PKVQKVVKER
     DVEPMDVSEP APPPSKTPSM ASGRTQDSAI DVTISEIPPP TSAATTSTQK PQKSVSFEDN
     EGYAETDGDQ QHEAVASSRS SSVQLKRKQM KLQKEQQQQQ QQSKESKKNG SEQDGSGDGG
     GLVNTYLRRK QLKQQQQVTA GAAGAGDVGG AGGVVDTLEI GGKKDRRHRA GMKTNGFFGP
     EGKYQPSSSD GIPRTGSFSQ PSTAATKPST FATLTSSASA TVFSKSADDS HIAVTTTNGS
     TESSSSVGGG DASKSVDEIM PLLHQTSITG AGPDGVGDGG VEAGDESDAA DGPMPMVKHG
     RKGHGHHGQD RGMMAFSRKK LKTKYMKSKA ASKGGGVVVL DGVAGTMTNG GVASDGEK
//
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