ID B0XBR3_CULQU Unreviewed; 900 AA.
AC B0XBR3;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Sarcosine dehydrogenase, mitochondrial {ECO:0000313|EMBL:EDS44412.1};
GN Name=6050482 {ECO:0000313|EnsemblMetazoa:CPIJ016929-PA};
GN ORFNames=CpipJ_CPIJ016929 {ECO:0000313|EMBL:EDS44412.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS44412.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS44412.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ016929-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ016929-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR EMBL; DS232648; EDS44412.1; -; Genomic_DNA.
DR RefSeq; XP_001867085.1; XM_001867050.1.
DR AlphaFoldDB; B0XBR3; -.
DR STRING; 7176.B0XBR3; -.
DR EnsemblMetazoa; CPIJ016929-RA; CPIJ016929-PA; CPIJ016929.
DR GeneID; 6050482; -.
DR KEGG; cqu:CpipJ_CPIJ016929; -.
DR VEuPathDB; VectorBase:CPIJ016929; -.
DR VEuPathDB; VectorBase:CQUJHB001383; -.
DR eggNOG; KOG2844; Eukaryota.
DR HOGENOM; CLU_007884_11_4_1; -.
DR InParanoid; B0XBR3; -.
DR OMA; PMKHAYI; -.
DR OrthoDB; 1815533at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR13847:SF200; SARCOSINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 47..405
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 409..462
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 467..780
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 804..889
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 900 AA; 100555 MW; 9F4FC2D72F883E03 CRC64;
MFRLGKRSFT KFKKQIAGQG LPSVTRIGQG LSRRSLSSES TLPESADVVI IGGGSAGCNT
LYQLTKRGIR AVLLEKNKLT AGTTWHTAGL VWRLRPNDVE IKLLASTRNL LMRLEEETDH
NSGWINNGGL FISHSDERLN EYKRLATLGK CFGIESHILT PEEAQEVFPL LDPAGFTGAL
YSPGDGVVDP AMMCTALTKA SVANGGMIVE DCSVSEIVTG ENLLGVRDVR GVVTNKGMLR
TNTVVNAMGV WGRDLIEPLG IHLPLIPMKH AYVVSETMDG INQMMPNIRD HDSSIYFRIQ
GKSICMGGYE NNPILLDRVP GDFHFGLYDL DYSVFDTHIQ GAVKICPEFG KAGIKSTICG
PESFTPDHKP LMGPDPIING LFHNCGFNSA GMMLGAGCAE QLAKWIIHDR PDLHMFAYDI
RRFSPKQKKA LNWATERSHE AYAKNYSIVF PHDEALAGRN FTVDPFHKQM IQHGAVMEER
HGWERPGYFL PEDTVVVQPY DWYGYYDYPK NTNTNYEEAL QKDYTFGFPE HHDLIGEEAH
TCRQEAVLFN LSYFCKLFLT GSQAKEAADW IFTADTNKPK GKTVYTCALN KRGGVEADVT
VSIVESGQGE LHDPIFKGRG YYIVAGGASA YHTKSHLLAT IQEKALRAVV TDQTEELGVL
SIQGPKSREI LQKITDFDLS DEEQLPPNSN AVLSLKINPF YSCNVRVLRV SFVGELGYEL
HIPEESCNDV YNALMKAGYK DGLRNAGYRA LYSLSSEKGY HLWGNDLRAD DTPVEANLGF
TCRKKGDYQG KAVVDRQLEN GINKKLVFFT LRDQVPIWGL EAVYRNGEII GHMRRGEYGY
TLQKPIGQAY VTRPDGDYVT NEFIRSGRYQ VEVMGRMYDA ECHLRSPFDP KGERILGIYK
//
