ID B0XEK3_CULQU Unreviewed; 1042 AA.
AC B0XEK3;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 90.
DE RecName: Full=Replication factor C subunit 1 {ECO:0000256|ARBA:ARBA00020401, ECO:0000256|PIRNR:PIRNR036578};
GN Name=6051676 {ECO:0000313|EnsemblMetazoa:CPIJ017892-PA};
GN ORFNames=CpipJ_CPIJ017892 {ECO:0000313|EMBL:EDS26030.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS26030.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS26030.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ017892-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ017892-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036578}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116, ECO:0000256|PIRNR:PIRNR036578}.
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DR EMBL; DS232839; EDS26030.1; -; Genomic_DNA.
DR RefSeq; XP_001868075.1; XM_001868040.1.
DR AlphaFoldDB; B0XEK3; -.
DR STRING; 7176.B0XEK3; -.
DR EnsemblMetazoa; CPIJ017892-RA; CPIJ017892-PA; CPIJ017892.
DR KEGG; cqu:CpipJ_CPIJ017892; -.
DR VEuPathDB; VectorBase:CPIJ017892; -.
DR VEuPathDB; VectorBase:CQUJHB014267; -.
DR eggNOG; KOG1968; Eukaryota.
DR HOGENOM; CLU_003574_0_1_1; -.
DR InParanoid; B0XEK3; -.
DR OMA; LICNERN; -.
DR OrthoDB; 6297at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd17752; BRCT_RFC1; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF6; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR036578};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR036578};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR036578};
KW Nucleus {ECO:0000256|PIRNR:PIRNR036578};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 268..354
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..990
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1042 AA; 114184 MW; 322A98CD4E1CFB76 CRC64;
MSKDIRSFFS VGGSKAKKPD PPRDSSSSSS KRKAVIVDSD EESTEHRKPS SSSSSSSKDK
SGHSKKRRVI DSDDEKSPVK KKVAPEPAAP KLKECKAEDF FGSAPVKRIE TPRPSKKAVK
EEVAVHSDEE FEKSLSEMVV PETPPPPPAA SKKKSEKVKS PAKNGGSGKE KNGHEESKKK
TPTPEKKSNG REEVKSTPPP AKKEKPASIK RESSAEQGTP KSTKKDLNES VLTDEERYER
KRMAAALYKK FQSRQGPANP GSKEIPKGTP TCLAGLQFVV TGVMESMERD ECAQVIKDFG
GKVVTSVSKK LTHMVVGEDA GPSKLAKADE LGIPQISEDQ LFDLIRERSG LPVKAESKPK
VKEEKPKIKE EKSPSKEKKR TKTAEQEVKK RTPEKHKLSE SVAKLPKIPK IEKRSPEQSK
PIKIEKKSPK KEPEMPPINR EETAYQKDIQ STDNMAWVDK YKPTSIKQII GQAGPASNVQ
KLLNWLSKWH SNHDGKKVLQ RPSPWAKNDD GAYFKAALLS GPPGVGKTTT ATLVCKELGF
DAVEFNASDT RSKKLLKEQV SELLTNKSLF GYFTGNGKGD KVTHKHVLVM DEVDGMAGNE
DRGGIQELIG LIKDSHVPII CMCNDRNHQK MRSLVNYCFD LRFNKPRVEQ IKVRRHDVGL
LQGGLKLAPG ALEEIIAGTG GDVRQTLNHL ALHSTGKTLG GTSLSAAQAK QEAQTARKDV
KMGPWDVIRK VFSAEDHRTM SIHDKSDLFF HDYSLAPLFV QENYLKVTPK VPKAQHLDQI
ALAADSLSRG DLIDRRIRSS MAWSLLPMQA MFSSVLPGEY MEGNFTGQIN FPGWLGKNSK
ASKRKRLAQE IHDHTRMSTS GSRLSVRLDY APYLLGSIVR PLQQKGSEGV QESLDVIKEY
RLLREDLESL VELTSWPKKK SPMDAVDGKV KAALTRAYNK EVAPYTYSVV NAVKKKKSEA
ADDAAAEAYG EDAEEAGGAP DSEEEKEDDD LENNAFIKVK KKPAGKGAAA TAGSSKAAGS
KGGSKAAKGG AGGSSSARGK KK
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