ID B0XEX2_CULQU Unreviewed; 539 AA.
AC B0XEX2;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Poly(A)-specific ribonuclease {ECO:0000313|EMBL:EDS26303.1, ECO:0000313|EnsemblMetazoa:CPIJ017645-PA};
GN Name=6051824 {ECO:0000313|EnsemblMetazoa:CPIJ017645-PA};
GN ORFNames=CpipJ_CPIJ017645 {ECO:0000313|EMBL:EDS26303.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS26303.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS26303.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ017645-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ017645-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR EMBL; DS232876; EDS26303.1; -; Genomic_DNA.
DR RefSeq; XP_001868194.1; XM_001868159.1.
DR AlphaFoldDB; B0XEX2; -.
DR STRING; 7176.B0XEX2; -.
DR EnsemblMetazoa; CPIJ017645-RA; CPIJ017645-PA; CPIJ017645.
DR KEGG; cqu:CpipJ_CPIJ017645; -.
DR VEuPathDB; VectorBase:CPIJ017645; -.
DR VEuPathDB; VectorBase:CQUJHB014710; -.
DR eggNOG; KOG1990; Eukaryota.
DR HOGENOM; CLU_018030_1_1_1; -.
DR InParanoid; B0XEX2; -.
DR OMA; DEWRNTI; -.
DR OrthoDB; 276176at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR CDD; cd02637; R3H_PARN; 1.
DR CDD; cd12428; RRM_PARN; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034042; PARN_R3H.
DR InterPro; IPR014789; PolyA-riboNase_RNA-binding.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR PANTHER; PTHR15092:SF44; POLY(A)-SPECIFIC RIBONUCLEASE PARN; 1.
DR Pfam; PF04857; CAF1; 1.
DR Pfam; PF08675; RNA_bind; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002320}.
FT DOMAIN 394..473
FT /note="Poly(A)-specific ribonuclease RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF08675"
FT REGION 109..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 61832 MW; A97CF6624DF5B5F5 CRC64;
MASDSKKKIN KNKKRSMGFD SAHFPKVRRV GLSWSCRFRV DPESGAVSYK CYNFYCFPKG
RVHVFACQGE SMRFLADHGF DFNKLFREGL SYCGEADEER MRMDLKERQE QRAAALEAEE
GEEANGNDAV NMVPVPATEE KLMAEIEERI GVFLASEEKD FTITNCNGFQ RKLVYQMIEA
KFRKQISTSS VELENKHKGI LVERKRTKEQ DRKLEQEKVA QENVDLESAV GLSLVLQELS
KTRKLIVGHN MLLDLMFVIR QFFRPLPYNF QDFKKTVREL FPLLLDTKYL CTNAELKVHV
FSSVLGHVFE AVRKEPFKLP EVKSGSEEHS YSMDQEKQHE AGYDAYLTGL CFLGLASYFK
VDLTNLTNDA TLKMYFNRIY LLRVSEVNYI YIYGKEPSFS RDHIFYITFP ENWRNVDILC
RFRNYGQVFI SWVNETSAFV TLHNRDHAAA VLKTIDKSNA AFTICTLNQF KAKQQCAGAK
RRYDSGGSDR GGLKRPADKE VTAAVVLPAV TATEVSNFGT PSQAKKPRQQ GTFADNDSW
//
