ID B0XF16_CULQU Unreviewed; 1319 AA.
AC B0XF16;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:EDS26364.1, ECO:0000313|EnsemblMetazoa:CPIJ017999-PA};
GN Name=6051880 {ECO:0000313|EnsemblMetazoa:CPIJ017999-PA};
GN ORFNames=CpipJ_CPIJ017999 {ECO:0000313|EMBL:EDS26364.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS26364.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS26364.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ017999-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ017999-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; DS232889; EDS26364.1; -; Genomic_DNA.
DR RefSeq; XP_001868238.1; XM_001868203.1.
DR STRING; 7176.B0XF16; -.
DR EnsemblMetazoa; CPIJ017999-RA; CPIJ017999-PA; CPIJ017999.
DR KEGG; cqu:CpipJ_CPIJ017999; -.
DR VEuPathDB; VectorBase:CPIJ017999; -.
DR VEuPathDB; VectorBase:CQUJHB011213; -.
DR VEuPathDB; VectorBase:CQUJHB018116; -.
DR eggNOG; KOG1494; Eukaryota.
DR HOGENOM; CLU_260041_0_0_1; -.
DR InParanoid; B0XF16; -.
DR OMA; CVDAYNI; -.
DR OrthoDB; 2918911at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR PANTHER; PTHR35578:SF8; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR35578; PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 861..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 895..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 933..954
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1025..1048
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1069..1095
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1136..1155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 345..395
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
FT REGION 17..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 705..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1249..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 371..402
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 20..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..779
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1249..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1271..1300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1319 AA; 143421 MW; 8F71930664A2F637 CRC64;
MLAEGTLHKR YRISWRRSSE EAAQPPQEVD QPQQEEDVCL SSRISDIASC CRLRISDRPG
CSDCCDPADD DDAAATASPF PFSSYPCSTA SSSTRKFGRR RRTHLPQLRP DTVKKVRVRT
PRQSRLVLIS TTILLPLLLL LHQPSCWAVL LDANGESAAG PAGGGGGGAP FGDGVGLSLG
GSFNLEKSIA AVFSRVAYGS TTTTKRSIPD NVYVPSLTTV STPLLTTFRY REKDKDPGMS
LGGSGSGGGA LGGTDLLGPG PGGAGGGAPH YNQQQISQNH RGYELDLERD HVLPTSAPNA
EILKSNSNPT YPNPNRHHGH DRHRHSNSTP YPHGQHSGLF RSDITKATYF STPLLLGKNG
LEKHFCLPKV NANEKELLKK AIQELKKNIQ NGEELVKKNS KLLVRAHAPG FGMAVRGKDL
GPVEVFDVDS VRRGPDGVCK SFLAFLDEDP GLKQVSLAPA VSTGGGPRLD TALPEQGEGG
EGSISLALEE TLSTGFLAQE GSLLRKDKPS GNTCGSRWGG HPKKGFPTNP MFPGDIPSYS
PPSRAFFTPP LPRNYTNPFA DKPTLRGTNS DSTIINTNTY VNRRPLPPPS LMPGHERIPI
RPDLNGSGAP AAPKVEEPVL VTGPASSSQS IEAQRRKPLN TPSEKSNKLE GGKSYGVDSK
FMLDGGGNSS AILPNGMHFP SISRILSGSN GRTQTIPDVL LRSVTSAPRP NQPTFDLNAG
GGGLPAVTSL SNAKNLNKGE GDEDGDGFEG GNENSGSRDE GEEEDDDDDG GGDDEEDVVG
EKIDGSFYST ASVATSTVSS AGGHPASSSS PITQKMPNLN LKSVMIKANA SGEEVGGGYG
NDRNFATDIE DISTWTIAWN IHVYLSAILF TILAVYSIFK IIFYDKLTHL FSQSYFISIH
LILIIICLLR IFYLCYDAYN IHFSFNLFTS ELLLNLPLTF LTTTFAILIL FLLLRSINHK
TNRYSSILRP LTIMIGSGVH VGLCVTLHLV ESYETQQFYH KQTQLLSRGG AAGHGPTNIQ
IPPRVLSLIC QIIYIFICLS LGILYLYMYR LLKRILHKSQ NYIHGYNNLS YAIHITIATA
LLFILLAALQ IYGAISISSQ TKVKLSPANM NDAAAAKKTL WASHIEIDWF QWGYQFSLRF
IEIVIIALLS WVTGLKTGTS KGVPREKDME QPNASGFALF PCTSSSSQEN FETDYPAVCN
ANTNLHTYTL RTGKPIYDDN FALNSLNLEQ NSAQDLQPND FQRSIETNSM RSSSHNYSNN
YNGSQQADQH DDFINDGEQM PDHYENPNFE LKHHHRGEPP GGVSNVKPTF TSHLFIDVD
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