ID B0XFX6_CULQU Unreviewed; 379 AA.
AC B0XFX6;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=ZAD domain-containing protein {ECO:0000259|PROSITE:PS51915};
GN Name=6052257 {ECO:0000313|EnsemblMetazoa:CPIJ018067-PA};
GN ORFNames=CpipJ_CPIJ018067 {ECO:0000313|EMBL:EDS27095.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS27095.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS27095.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ018067-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ018067-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
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DR EMBL; DS232970; EDS27095.1; -; Genomic_DNA.
DR RefSeq; XP_001868548.1; XM_001868513.1.
DR AlphaFoldDB; B0XFX6; -.
DR EnsemblMetazoa; CPIJ018067-RA; CPIJ018067-PA; CPIJ018067.
DR KEGG; cqu:CpipJ_CPIJ018067; -.
DR VEuPathDB; VectorBase:CPIJ018067; -.
DR VEuPathDB; VectorBase:CQUJHB002960; -.
DR eggNOG; ENOG502TBUY; Eukaryota.
DR HOGENOM; CLU_714152_0_0_1; -.
DR InParanoid; B0XFX6; -.
DR OMA; NVEPRTY; -.
DR OrthoDB; 3456032at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 2.20.25.240; -; 1.
DR Gene3D; 3.40.1800.20; -; 1.
DR InterPro; IPR012934; Znf_AD.
DR InterPro; IPR007588; Znf_FLYWCH.
DR Pfam; PF04500; FLYWCH; 1.
DR Pfam; PF07776; zf-AD; 1.
DR SMART; SM00868; zf-AD; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS51915; ZAD; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU01263}; Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU01263};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01263}.
FT DOMAIN 14..89
FT /note="ZAD"
FT /evidence="ECO:0000259|PROSITE:PS51915"
FT REGION 142..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..324
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 16
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 19
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 62
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
FT BINDING 65
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01263"
SQ SEQUENCE 379 AA; 42876 MW; 17013F68D8C12EB4 CRC64;
MTNVTVVFEY EEPEYCRLCL AKQTNDNDLT MIESDTHGII RELLQIQVRE GLDKTDSDAF
ICSTCVESLE EFHSYRTRCR RNNVALQKKA EERKKQQIEL AKSAIANTNV LDQVKDGEPI
RVVIRMNAEG KASVRLQVHS KPQIKTEEVP PAEVEAEPST STASTSKATT PTIPAVSEKD
GKSPPQKLIR LPMQPFYFYK ATAKSSYGLI YGGYRYCASV PRKQHVYWMC EQRKTHRCQA
VVLVNKIYTE FLLNCGHNHD PPQVGTQQVF KAAEVLPYVM KSERAREEQL ARNVEPRTYS
RKKVVKEEDY TSEDDDEEYS SGDDSDAVPA EVKKEDSEDE EEEAKPPASD AAEATSPVAV
KKEQVDDGDE CMYIIAELT
//
