ID B0XIJ4_CULQU Unreviewed; 578 AA.
AC B0XIJ4;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:EDS29393.1, ECO:0000313|EnsemblMetazoa:CPIJ019194-PA};
GN Name=6053363 {ECO:0000313|EnsemblMetazoa:CPIJ019194-PA};
GN ORFNames=CpipJ_CPIJ019194 {ECO:0000313|EMBL:EDS29393.1};
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1] {ECO:0000313|EMBL:EDS29393.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB {ECO:0000313|EMBL:EDS29393.1};
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.,
RA Hannick L., Megy K., O'Leary S., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:CPIJ019194-PA}
RP IDENTIFICATION.
RC STRAIN=JHB {ECO:0000313|EnsemblMetazoa:CPIJ019194-PA};
RG EnsemblMetazoa;
RL Submitted (FEB-2021) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; DS233313; EDS29393.1; -; Genomic_DNA.
DR RefSeq; XP_001869466.1; XM_001869431.1.
DR AlphaFoldDB; B0XIJ4; -.
DR STRING; 7176.B0XIJ4; -.
DR EnsemblMetazoa; CPIJ019194-RA; CPIJ019194-PA; CPIJ019194.
DR KEGG; cqu:CpipJ_CPIJ019194; -.
DR VEuPathDB; VectorBase:CPIJ019194; -.
DR VEuPathDB; VectorBase:CQUJHB006408; -.
DR eggNOG; KOG1238; Eukaryota.
DR HOGENOM; CLU_002865_7_0_1; -.
DR InParanoid; B0XIJ4; -.
DR OMA; EEVWNSY; -.
DR OrthoDB; 3382025at2759; -.
DR Proteomes; UP000002320; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF227; GLUCOSE DEHYDROGENASE [FAD, QUINONE]-LIKE PROTEIN; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 2.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002320};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 13..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 270..284
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 125
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 129
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 235
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 544
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 578 AA; 65095 MW; 2F23F3401359D934 CRC64;
MSLLGLISAK FTFIFYLIGT TLLCAFLNGS YRFYEYYYDN PPVKTSYEYI IVGTGTAGSI
IAAGIPSRDV LVVEAGSMRT SLMDVPLFQP LLQGTQYDWQ YQTEPQRNAC RALEGQRSNW
PMGKVFGGTH MLNNMIHFDM MGNTDFSGWF ETPELTRKFL DYFHRWGRDP TIPVERLQYG
TEFGEDFFCE KMEELYSRLF AKPNVTARNG MRRTASHYYW EQRRPGHELL LNAHVLKINV
ENGKAIGLVL EKSNRTYEIR ASKGIILSAG TVGSPKILLH SGIGPQKHLK AVRIPLVQNL
PVGENLQDHI TTGMDLLLWP EKLPLRPLDL ISPLNLWNFF NGKNSSLLLP GCEGLGGMLL
PDLPRGLILG LGFMVMPAGI ASDGGAHLHK LINLREKVYT QYFQRILEQN LQSVSILPVL
LQPKSRGHIR LRDANPHSPP LIDPNYLQHP EDLDNLVLGI NIVKEYLEEM NSKKAELNPL
PFPGCRKFTF DTKPYWECYV QSLTLTMYHP VGTCRMGPKR SKKAVVSNRD LAVHGVSGLY
VVDGSAIPKL PTGNPNSAIA ALAHYFLKVK FNVDLLGR
//
