ID B0YLN3_GHVS Unreviewed; 953 AA.
AC B0YLN3;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN ORFNames=SGHV079 {ECO:0000313|EMBL:ABQ08852.1};
OS Glossina hytrovirus (isolate Glossina pallidipes/Ethiopia/Seibersdorf/-)
OS (GHV).
OC Viruses; Naldaviricetes; Lefavirales; Hytrosaviridae; Glossinavirus;
OC Glossinavirus glopallidipedis.
OX NCBI_TaxID=379529 {ECO:0000313|EMBL:ABQ08852.1, ECO:0000313|Proteomes:UP000011301};
OH NCBI_TaxID=7393; Glossina (tsetse flies).
RN [1] {ECO:0000313|EMBL:ABQ08852.1, ECO:0000313|Proteomes:UP000011301}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Glossina
RC pallidipes/Ethiopia/Seibersdorf/- {ECO:0000313|Proteomes:UP000011301};
RX PubMed=17070938; DOI=10.1016/j.jviromet.2006.09.018;
RA Abd-Alla A., Bossin H., Cousserans F., Parker A., Bergoin M., Robinson A.;
RT "Development of a non-destructive PCR method for detection of the salivary
RT gland hypertrophy virus (SGHV) in tsetse flies.";
RL J. Virol. Methods 139:143-149(2007).
RN [2] {ECO:0000313|EMBL:ABQ08852.1, ECO:0000313|Proteomes:UP000011301}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Glossina
RC pallidipes/Ethiopia/Seibersdorf/- {ECO:0000313|Proteomes:UP000011301};
RX PubMed=18272583; DOI=10.1128/JVI.02588-07;
RA Abd-Alla A.M., Cousserans F., Parker A.G., Jehle J.A., Parker N.J.,
RA Vlak J.M., Robinson A.S., Bergoin M.;
RT "Genome analysis of a Glossina pallidipes salivary gland hypertrophy virus
RT reveals a novel, large, double-stranded circular DNA virus.";
RL J. Virol. 82:4595-4611(2008).
CC -!- FUNCTION: Replicates the viral genome, host DNA polymerases cannot
CC substitute for the viral enzyme in this process.
CC {ECO:0000256|ARBA:ARBA00002701}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; EF568108; ABQ08852.1; -; Genomic_DNA.
DR RefSeq; YP_001687027.1; NC_010356.1.
DR GeneID; 5950871; -.
DR KEGG; vg:5950871; -.
DR OrthoDB; 165at10239; -.
DR Proteomes; UP000011301; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000011301};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Viral DNA replication {ECO:0000256|ARBA:ARBA00023109}.
FT DOMAIN 85..375
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 442..901
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 953 AA; 111498 MW; 27220FC91EECB4D0 CRC64;
MPNDNADDDD DAQPDIYSDI YQIHDTKLQV FGHDLELNIS CVNSLGKKHL FNINHGIFTD
VFIESFSNND FNIINDYFIQ HKNIDLNDIT MRNVILEYHT QLIPFTKTQI PMWRLRIYKK
YLEDIEYCSK NMNRRVFCNS QFDDTILMIQ RNIGIFFKFN RFINDDKPYT RSYDNNNVCV
YSDVFYDSIT KPKIEIKKFF PYKLMSIDIE VYNPNPDSFP DASREECKII IIACAYLETK
TTDIFYTLVP QWDFMTDPSA EYKRNYIRCK NEVHLLIQFA NSINYNNVDI MTGYNMKNFD
LMYIYNRMKL LGLLRHTVNW NMQKKQLYIS KCQKYSNQQG TRDSINTNIF GFVIIDMFEY
ISSNFKLRSY KLNDVVGVFL RHGEKKLDID YKNISVFHDR GSKEDCHHLL DYCAVDAELC
NSLLINRSTY SNVFAVAHIC HIPIRYVIDR GQQIRIYSMM CEYIWRQDIY TIPLVTGRRV
QSKYNYEGAR VIEPKKGFYN TAIATLDFAS LYPSIMIGYN MCYTTLIQGI TTPPGHVDSI
NLVKYNGLNC RIVPGTSRVA FVDCSEREGI LPSILKVLLQ SRAEVRKKMK TITDKDELAL
MDSMQLGFKL CANSAYGYMA ASTSKLPCID ISSSVTCIGR FLLTAIETIC KEKFKKDVIY
GDTDSVMVDT KLISVHEALS LGKEMAKICT ELLNLPSLKL EFEKVYMPYL LICKKRYIGA
HWTKPEMYDK IDTKGVETAR RDNCKLLQII LKIIIHDSMN NGLDKVFEKI ENELLPFSEL
WKSYLNDNCF KLDKQDKTKI TSEIIEKFIM SKKYTKMDYV SIQPHVSIIK RLSNRQFNHG
ERIEYVIASK VLILTDKKQP DKLLSDMAFL PEEVLEKNLY IHIPYYINGQ VLVPALRFIE
PMGHKYVIIF ISLLKRLFPR MNLTTYKKYN NVINDNKSTV FIDQKITKFF TNK
//
