ID B0Z663_XENTR Unreviewed; 958 AA.
AC B0Z663;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Protocadherin alpha 13 {ECO:0000313|Ensembl:ENSXETP00000055406};
DE SubName: Full=Protocadherin delta 1 {ECO:0000313|EMBL:ABY91219.1};
DE SubName: Full=Protocadherin-10 isoform X1 {ECO:0000313|RefSeq:XP_004912840.1};
GN Name=pcdha13 {ECO:0000313|Ensembl:ENSXETP00000055406,
GN ECO:0000313|RefSeq:XP_004912840.1,
GN ECO:0000313|Xenbase:XB-GENE-1113164};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:ABY91219.1};
RN [1] {ECO:0000313|EMBL:ABY91219.1}
RP NUCLEOTIDE SEQUENCE.
RA Yu W.-P., Venkatesh B.;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABY91219.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18319338; DOI=10.1073/pnas.0800398105;
RA Yu W.P., Rajasegaran V., Yew K., Loh W.L., Tay B.H., Amemiya C.T.,
RA Brenner S., Venkatesh B.;
RT "Elephant shark sequence reveals unique insights into the evolutionary
RT history of vertebrate genes: A comparative analysis of the protocadherin
RT cluster.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:3819-3824(2008).
RN [3] {ECO:0000313|Ensembl:ENSXETP00000055406}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000055406};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000055406}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:XP_004912840.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_004912840.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_004912840.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; EU267080; ABY91219.1; -; Genomic_DNA.
DR RefSeq; XP_004912840.1; XM_004912783.4.
DR PaxDb; 8364-ENSXETP00000055406; -.
DR Ensembl; ENSXETT00000055406; ENSXETP00000055406; ENSXETG00000016119.
DR GeneID; 779558; -.
DR KEGG; xtr:779558; -.
DR AGR; Xenbase:XB-GENE-1113164; -.
DR CTD; 56136; -.
DR Xenbase; XB-GENE-1113164; pcdha13.
DR eggNOG; KOG3594; Eukaryota.
DR OMA; GMKEYKM; -.
DR OrthoDB; 4259465at2759; -.
DR TreeFam; TF332299; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Bgee; ENSXETG00000016119; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF296; PROTOCADHERIN GAMMA-C3; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..958
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015087016"
FT TRANSMEM 692..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..134
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 135..243
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 244..351
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 352..456
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 457..566
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 581..678
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 826..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 105988 MW; 1336CEB0995ED2C3 CRC64;
MFLCGVWGRR QDLGQLLLVL LTCCPAWASS QIRYSVPEEL EHGAFVGNIA EDLGLDISKL
SPRRFRIVSG TSKQHLEVNL ENGILFVNEK IDREEVCELQ PVCSLHLQVV LENPLELYRV
EVEVLDINDN APSFPWHDYV LEVTESAAPG ARFPLESAQD PDVGTNSLRT YKLSPNGFFS
LEVQSRSDGS KFAELVLERP LDREQQKTHR VLLTAMDGGL PERSGTALVT VSVLDANDNV
PTFDQSFYRV SLYENVPKGT LVIKLNATDL DEGTNGEIEY SFSGHAPQKV RDLFLVEPRS
GQVRVKGVLD YEKSNLYELY VQAKDRGPSA VAVHCRVLVN LLDVNDNAPE IILTSVSTPV
MEDASPGTVI AVISVMDRDS GDNGEVNCEI PQNVPFQLHS SYKNYYTLVT TELLDREVLS
EYNITISARD FGSPPLLTKK VINVQVTDIN DNTPTFLQPS YTVYVLENNP PGASICSVTA
LDPDCKQNAY LSYSIMEGQI QGMPVSTYVS INSDSGNIYA LRSFDYEQIR NFQIRVQAQD
AGFPPLSSNV TINVFILDQN DNAPVVVSPL PKNGTVATDV IPRSADPGYL IGKIAATDAD
SGQNSRLSYQ IIQATDSTLF SIALYTGELR TIRVITDRDA TKHRLLIQIR DNGQPALSTS
VSIVLTVVDS MPESHSEFND VPLNSDPATS SLTLYLIVSL GSVSFTFLVA IIVLTVIKCH
KDRLSLQDYK CSLPTCCCMR SESSGGVFKN SNINLQISSG NKVQTNCMET TGSAPPNYCY
KVCLTPESAK SDFMFLKPYN SSTQNNEKLP EKVAPGRTGH AVNKAVNEIK LPNTDWSPQK
EQKPSLKSSQ SLEDLGTRKG SKKDHDRLRT LVSPVTDIKK KTSESNGVWS PKYGLQFQQH
VPSLDYQHNV YIPGTPTLLA NKQGVFEEKN SFSTFGKKRR MSCYGEVRDD MMINNDLK
//
