ID B1AAQ5_TAKRU Unreviewed; 146 AA.
AC B1AAQ5;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Insulin {ECO:0000256|ARBA:ARBA00020180};
DE AltName: Full=Relaxin-3 {ECO:0000256|ARBA:ARBA00040355};
GN Name=RFLC2 {ECO:0000313|EMBL:ACA13583.1};
GN Synonyms=rln3b {ECO:0000313|Ensembl:ENSTRUP00000032102.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|EMBL:ACA13583.1};
RN [1] {ECO:0000313|EMBL:ACA13583.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18463305; DOI=10.1101/gr.7119108;
RA Park J.I., Semyonov J., Chang C.L., Yi W., Warren W., Hsu S.Y.;
RT "Origin of INSL3-mediated testicular descent in therian mammals.";
RL Genome Res. 18:974-985(2008).
RN [2] {ECO:0000313|EMBL:ACA13583.1}
RP NUCLEOTIDE SEQUENCE.
RA Park J., Semyonov J., Chang C.L., Yi W., Warren W., Hsu S.Y.T.;
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSTRUP00000032102.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [4] {ECO:0000313|Ensembl:ENSTRUP00000032102.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|ARBA:ARBA00011207}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; EU437452; ACA13583.1; -; mRNA.
DR STRING; 31033.ENSTRUP00000032102; -.
DR Ensembl; ENSTRUT00000032225.3; ENSTRUP00000032102.1; ENSTRUG00000012677.3.
DR eggNOG; ENOG502S2Z0; Eukaryota.
DR GeneTree; ENSGT00940000154396; -.
DR HOGENOM; CLU_120043_0_0_1; -.
DR OMA; SSTCCKW; -.
DR OrthoDB; 5353072at2759; -.
DR TreeFam; TF333404; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04365; IlGF_relaxin_like; 1.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR20968; ILGF DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR20968:SF0; RELAXIN-3; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..146
FT /note="Insulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014084680"
FT DOMAIN 26..146
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 146 AA; 16153 MW; DF55C53F96806E6F CRC64;
MLKAVVLAVC LLAAGVQPMD DPIYGVKLCG REFIRAVIFT CGGSRWKRSL MSAEVFEDPF
SSHQEESPEG PSHNGIQSIL QRSRELSFPP KNNQEEVFSR SARSFITEEI LEALRKADRK
GRDVVVGLSN ACCKWGCSKS EISSLC
//
