ID B1AB88_HORSE Unreviewed; 93 AA.
AC B1AB88;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 24-JAN-2024, entry version 106.
DE RecName: Full=C-C motif chemokine {ECO:0000256|RuleBase:RU361150};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|EMBL:ABZ91984.1};
RN [1] {ECO:0000313|EMBL:ABZ91984.1}
RP NUCLEOTIDE SEQUENCE.
RA Tompkins D., Hudgens T., Horohov D., Wagner B., Baldwin C.;
RT "U.S. Veterinary Immune Reagent Network: Expressed Equine Gene Sequences.";
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361150}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000256|ARBA:ARBA00010868, ECO:0000256|RuleBase:RU361150}.
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DR EMBL; EU438775; ABZ91984.1; -; mRNA.
DR RefSeq; NP_001108413.1; NM_001114941.1.
DR GeneID; 100057909; -.
DR KEGG; ecb:100057909; -.
DR CTD; 6348; -.
DR HOGENOM; CLU_141716_4_2_1; -.
DR OMA; TACCFRY; -.
DR OrthoDB; 4265193at2759; -.
DR TreeFam; TF334888; -.
DR Bgee; ENSECAG00000024640; Expressed in leukocyte and 16 other cell types or tissues.
DR ExpressionAtlas; B1AB88; baseline.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0042056; F:chemoattractant activity; ISS:UniProtKB.
DR GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR GO; GO:0016301; F:kinase activity; ISS:UniProtKB.
DR GO; GO:0016004; F:phospholipase activator activity; ISS:UniProtKB.
DR GO; GO:0004672; F:protein kinase activity; ISS:UniProtKB.
DR GO; GO:0043615; P:astrocyte cell migration; ISS:UniProtKB.
DR GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
DR GO; GO:0001775; P:cell activation; ISS:UniProtKB.
DR GO; GO:0007267; P:cell-cell signaling; ISS:UniProtKB.
DR GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0048245; P:eosinophil chemotaxis; ISS:UniProtKB.
DR GO; GO:0043308; P:eosinophil degranulation; ISS:UniProtKB.
DR GO; GO:0006887; P:exocytosis; ISS:UniProtKB.
DR GO; GO:0071621; P:granulocyte chemotaxis; ISS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; ISS:UniProtKB.
DR GO; GO:0048247; P:lymphocyte chemotaxis; ISS:UniProtKB.
DR GO; GO:0048246; P:macrophage chemotaxis; ISS:UniProtKB.
DR GO; GO:0002548; P:monocyte chemotaxis; ISS:UniProtKB.
DR GO; GO:0043922; P:negative regulation by host of viral transcription; ISS:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
DR GO; GO:0030593; P:neutrophil chemotaxis; ISS:UniProtKB.
DR GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
DR GO; GO:0051928; P:positive regulation of calcium ion transport; ISS:UniProtKB.
DR GO; GO:0050850; P:positive regulation of calcium-mediated signaling; ISS:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:UniProtKB.
DR GO; GO:2000503; P:positive regulation of natural killer cell chemotaxis; ISS:UniProtKB.
DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR GO; GO:0050795; P:regulation of behavior; ISS:UniProtKB.
DR GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
DR GO; GO:0051930; P:regulation of sensory perception of pain; ISS:UniProtKB.
DR GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0070723; P:response to cholesterol; ISS:UniProtKB.
DR GO; GO:0009636; P:response to toxic substance; ISS:UniProtKB.
DR GO; GO:0023052; P:signaling; ISS:UniProtKB.
DR GO; GO:0010818; P:T cell chemotaxis; ISS:UniProtKB.
DR CDD; cd00272; Chemokine_CC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015:SF183; C-C MOTIF CHEMOKINE 3; 1.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 2: Evidence at transcript level;
KW Chemotaxis {ECO:0000256|RuleBase:RU361150};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU361150};
KW Secreted {ECO:0000256|RuleBase:RU361150};
KW Signal {ECO:0000256|RuleBase:RU361150}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU361150"
FT CHAIN 24..93
FT /note="C-C motif chemokine"
FT /evidence="ECO:0000256|RuleBase:RU361150"
FT /id="PRO_5013982005"
SQ SEQUENCE 93 AA; 10323 MW; 59A79FC7F3383F4C CRC64;
MKVPVAALAV LLCTMALCSQ VFSVPFGADT PTACCFSYVS RQIPRKFIND YYETSSQCSK
PAIIFQTKRS RQVCADPSEA WVQEYVTDLE LSA
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