ID B1AC67_CHICK Unreviewed; 192 AA.
AC B1AC67;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=Relaxin 3 {ECO:0000313|EMBL:QVY19145.1, ECO:0000313|Ensembl:ENSGALP00010017876.1};
DE SubName: Full=Relaxin-like peptide locus B {ECO:0000313|EMBL:ACA25600.1};
GN Name=RFLB {ECO:0000313|EMBL:ACA25600.1};
GN Synonyms=RLN3 {ECO:0000313|Ensembl:ENSGALP00010017876.1}, RLN3L
GN {ECO:0000313|EMBL:QVY19145.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:ACA25600.1};
RN [1] {ECO:0000313|EMBL:ACA25600.1}
RP NUCLEOTIDE SEQUENCE.
RA Park J., Semyonov J., Chang C.L., Yi W., Warren W., Hsu S.Y.T.;
RT "Origin of INSL3-mediated Testicular Descent in Therian Mammals.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QVY19145.1}
RP NUCLEOTIDE SEQUENCE.
RA Lv C., Zhang J., Wan Y., Li J., Wang Y.;
RT "Characterization of relaxin 3-like (RLN3L) and relaxin family peptide
RT receptors (RXFP1, RXFP2L and RXFP3) in the chickens.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSGALP00010017876.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010017876.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|ARBA:ARBA00011207}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034}.
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DR EMBL; EU442364; ACA25600.1; -; mRNA.
DR EMBL; MT263682; QVY19145.1; -; mRNA.
DR RefSeq; NP_001106671.1; NM_001113200.1.
DR STRING; 9031.ENSGALP00000024190; -.
DR PaxDb; 9031-ENSGALP00000024190; -.
DR Ensembl; ENSGALT00010030812.1; ENSGALP00010017876.1; ENSGALG00010012847.1.
DR GeneID; 427223; -.
DR KEGG; gga:427223; -.
DR CTD; 117579; -.
DR VEuPathDB; HostDB:geneid_427223; -.
DR eggNOG; ENOG502S5T3; Eukaryota.
DR GeneTree; ENSGT00940000154396; -.
DR HOGENOM; CLU_120043_0_0_1; -.
DR OMA; AGICCKW; -.
DR OrthoDB; 4265509at2759; -.
DR TreeFam; TF333404; -.
DR PRO; PR:B1AC67; -.
DR Proteomes; UP000000539; Chromosome Z.
DR Bgee; ENSGALG00000015028; Expressed in granulocyte and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:1900721; P:positive regulation of uterine smooth muscle relaxation; IMP:AgBase.
DR CDD; cd04365; IlGF_relaxin_like; 1.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR PANTHER; PTHR20968; ILGF DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR20968:SF4; RELAXIN-LIKE PEPTIDE LOCUS B; 1.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..192
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015087031"
FT DOMAIN 40..190
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 192 AA; 20430 MW; F5A27BC5C6217314 CRC64;
MGAKLRLLCA AAALLSVAVP GQPGAQGALV PAGDGDGYGV KLCGREFIRA VIFTCGGSRW
KRLSLMAMEP APAADSSQAA SNNLLGRFKM QSAVGPEMQR SNSFLGLETL KDLYSLNDYN
EYESMADDFK ELLRQLEEAA QGDGGGAGVA PLGPSSYPWA RYPRRKRESL GLAGMCCKWG
CTKAEISTIC RV
//
