ID B1AP58_HUMAN Unreviewed; 204 AA.
AC B1AP58;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Carboxypeptidase N subunit 1 {ECO:0000313|Ensembl:ENSP00000410895.1};
DE Flags: Fragment;
GN Name=CPN1 {ECO:0000313|Ensembl:ENSP00000410895.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000410895.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000410895.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000410895.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
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DR EMBL; AL441886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; B1AP58; -.
DR SMR; B1AP58; -.
DR MassIVE; B1AP58; -.
DR PeptideAtlas; B1AP58; -.
DR ProteomicsDB; 3282; -.
DR Antibodypedia; 31135; 270 antibodies from 29 providers.
DR Ensembl; ENST00000441382.1; ENSP00000410895.1; ENSG00000120054.12.
DR UCSC; uc057vin.1; human.
DR HGNC; HGNC:2312; CPN1.
DR VEuPathDB; HostDB:ENSG00000120054; -.
DR GeneTree; ENSGT00940000158235; -.
DR HOGENOM; CLU_006722_3_1_1; -.
DR OMA; RNQRIVQ; -.
DR ChiTaRS; CPN1; human.
DR Proteomes; UP000005640; Chromosome 10.
DR Bgee; ENSG00000120054; Expressed in right lobe of liver and 34 other cell types or tissues.
DR ExpressionAtlas; B1AP58; baseline and differential.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd11308; Peptidase_M14NE-CP-C_like; 1.
DR Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR11532:SF80; CARBOXYPEPTIDASE N CATALYTIC CHAIN; 1.
DR PANTHER; PTHR11532; PROTEASE M14 CARBOXYPEPTIDASE; 1.
DR Pfam; PF13620; CarboxypepD_reg; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR SMART; SM00631; Zn_pept; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00133; CARBOXYPEPT_ZN_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:B1AP58,
KW ECO:0007829|PeptideAtlas:B1AP58};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 13..23
FT /note="Peptidase M14 carboxypeptidase A"
FT /evidence="ECO:0000259|PROSITE:PS00133"
FT NON_TER 204
FT /evidence="ECO:0000313|Ensembl:ENSP00000410895.1"
SQ SEQUENCE 204 AA; 22880 MW; 8F4C92F2BE1870F5 CRC64;
MHSFNFVLSA NLHGGAVVAN YPYDKSFEHR VRGVRRTAST PTPDDKLFQK LAKVYSYAHG
WMFQGWNCGD YFPDGITNGA SWYSLSKGMQ DFNYLHTNCF EITLELSCDK FPPEEELQRE
WLGNREALIQ FLEQVHQGIK GMVLDENYNN LANAVISVSG INHDVTSGDH GDYFRLLLPG
IYTVSATAPG YDPETVTVTV GPAE
//
