ID B1AQ77_MOUSE Unreviewed; 456 AA.
AC B1AQ77;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 121.
DE SubName: Full=Keratin 15 {ECO:0000313|Ensembl:ENSMUSP00000103034.3};
GN Name=Krt15 {ECO:0000313|Ensembl:ENSMUSP00000103034.3,
GN ECO:0000313|MGI:MGI:96689};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000103034.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000103034.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000103034.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000103034.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000103034.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_032495.2; NM_008469.2.
DR AlphaFoldDB; B1AQ77; -.
DR SMR; B1AQ77; -.
DR IntAct; B1AQ77; 2.
DR MINT; B1AQ77; -.
DR jPOST; B1AQ77; -.
DR PeptideAtlas; B1AQ77; -.
DR ProteomicsDB; 338801; -.
DR Antibodypedia; 3601; 995 antibodies from 42 providers.
DR DNASU; 16665; -.
DR Ensembl; ENSMUST00000107411.3; ENSMUSP00000103034.3; ENSMUSG00000054146.9.
DR GeneID; 16665; -.
DR KEGG; mmu:16665; -.
DR UCSC; uc007lkk.2; mouse.
DR AGR; MGI:96689; -.
DR CTD; 3866; -.
DR MGI; MGI:96689; Krt15.
DR VEuPathDB; HostDB:ENSMUSG00000054146; -.
DR GeneTree; ENSGT00940000154403; -.
DR HOGENOM; CLU_012560_8_3_1; -.
DR OMA; ADLRNDM; -.
DR OrthoDB; 4640531at2759; -.
DR PhylomeDB; B1AQ77; -.
DR TreeFam; TF332742; -.
DR BioGRID-ORCS; 16665; 3 hits in 78 CRISPR screens.
DR ChiTaRS; Krt15; mouse.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000054146; Expressed in conjunctival fornix and 110 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF164; KERATIN, TYPE I CYTOSKELETAL 15; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Proteomics identification {ECO:0007829|EPD:B1AQ77,
KW ECO:0007829|MaxQB:B1AQ77};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 98..410
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 102..136
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 202..247
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 354..409
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 456 AA; 49494 MW; 9D2A81EFB7D5D301 CRC64;
MATTFLQTSS TFGGSSTRGA SLRAGGGSFG GGSLYGGGGS RSISASSARF VSSGAGGGFG
GGMSCGFGGG FGGGFGGGFG GGFGDFGGGD GGLLSGNEKV TMQNLNDRLA SYLDKVRALE
QANTELEVKI RDWYQKQSPA SPDRDYSHYF KTMEEIRDKI LAATIDNSRV VLEIDNARLA
ADDFRLKYEN ELTLRQGVEA DINGLRRVLD ELTLARTDLE MQIEQLNEEL AYLKKNHEEE
MKEFSSQLAG QVNVEMDAAP GVDLTRMLAE MREQYEAIAE KNRRDVEAWF FSKTEELNKE
VASNTEMIQT SKTEITDLRR TLQGLEIELQ SQLSMKAGLE NSLAEVECRY ATQLQQIQGV
ITGLETQLSE LRCEMEAQNQ EYNMLLDIKT RLEQEIATYR NLLEGQDAKM AGIGVREVSL
GGSSGGGGSS SSSSNFHISV EESVDGKVVS SRKREI
//
