ID B1AVA6_MOUSE Unreviewed; 247 AA.
AC B1AVA6;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Calcium channel, voltage-dependent, alpha 1F subunit {ECO:0000313|Ensembl:ENSMUSP00000115012.2};
DE Flags: Fragment;
GN Name=Cacna1f {ECO:0000313|Ensembl:ENSMUSP00000115012.2,
GN ECO:0000313|MGI:MGI:1859639};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115012.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000115012.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115012.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000115012.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115012.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR AlphaFoldDB; B1AVA6; -.
DR SMR; B1AVA6; -.
DR ProteomicsDB; 326926; -.
DR Antibodypedia; 26145; 123 antibodies from 19 providers.
DR Ensembl; ENSMUST00000156047.2; ENSMUSP00000115012.2; ENSMUSG00000031142.18.
DR AGR; MGI:1859639; -.
DR MGI; MGI:1859639; Cacna1f.
DR VEuPathDB; HostDB:ENSMUSG00000031142; -.
DR GeneTree; ENSGT00940000159855; -.
DR Proteomes; UP000000589; Chromosome X.
DR Bgee; ENSMUSG00000031142; Expressed in retinal neural layer and 12 other cell types or tissues.
DR ExpressionAtlas; B1AVA6; baseline and differential.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF2; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU003808};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 45..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..170
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 180..233
FT /note="Voltage-dependent L-type calcium channel IQ-
FT associated"
FT /evidence="ECO:0000259|Pfam:PF16905"
FT NON_TER 247
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000115012.2"
SQ SEQUENCE 247 AA; 28076 MW; 53C23EBD9D10EC85 CRC64;
MSSEDSSRIS ITFFRLFRVM RLVKLLSKGE GIRTLLWTFI KSFQALPYVA LLIAMIFFIY
AVIGMQMFGK VALQDGTQIN RNNNFQTFPQ AVLLLFRCAT GEAWQEIMLA SLPGNRCDPE
SDFGPGEEFT CGSSFAIVYF ISFFMLCAFL IINLFVAVIM DNFDYLTRDW SILGPHHLDE
FKRIWSEYDP GAKGRIKHLD VVALLRRIQP PLGFGKLCPH RVACKRLVAM NVPLNSDGTV
TFNATLF
//
