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Database: UniProt
Entry: B1AWJ5
LinkDB: B1AWJ5
Original site: B1AWJ5 
ID   TMM8B_MOUSE             Reviewed;         472 AA.
AC   B1AWJ5; B9EJV2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   10-APR-2019, entry version 66.
DE   RecName: Full=Transmembrane protein 8B;
DE   AltName: Full=Protein NGX6;
GN   Name=Tmem8b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May function as a regulator of the EGFR pathway.
CC       Probable tumor suppressor which may function in cell growth,
CC       proliferation and adhesion (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: May interact with EZR. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000250|UniProtKB:A6NDV4}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:A6NDV4}. Cytoplasm
CC       {ECO:0000250|UniProtKB:A6NDV4}. Nucleus
CC       {ECO:0000250|UniProtKB:A6NDV4}. Mitochondrion
CC       {ECO:0000250|UniProtKB:A6NDV4}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:A6NDV4}. Note=Also detected in
CC       mitochondrion and endoplasmic reticulum.
CC       {ECO:0000250|UniProtKB:A6NDV4}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TMEM8 family. {ECO:0000305}.
DR   EMBL; AL732626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC147569; AAI47570.1; -; mRNA.
DR   EMBL; BC147574; AAI47575.1; -; mRNA.
DR   EMBL; BC151067; AAI51068.1; -; mRNA.
DR   EMBL; BC151070; AAI51071.1; -; mRNA.
DR   CCDS; CCDS51168.1; -.
DR   RefSeq; NP_001078977.1; NM_001085508.2.
DR   RefSeq; XP_011248332.1; XM_011250030.2.
DR   UniGene; Mm.171489; -.
DR   STRING; 10090.ENSMUSP00000103497; -.
DR   iPTMnet; B1AWJ5; -.
DR   PhosphoSitePlus; B1AWJ5; -.
DR   PaxDb; B1AWJ5; -.
DR   PRIDE; B1AWJ5; -.
DR   Ensembl; ENSMUST00000107864; ENSMUSP00000103496; ENSMUSG00000078716.
DR   Ensembl; ENSMUST00000107865; ENSMUSP00000103497; ENSMUSG00000078716.
DR   Ensembl; ENSMUST00000167153; ENSMUSP00000129760; ENSMUSG00000078716.
DR   GeneID; 242409; -.
DR   KEGG; mmu:242409; -.
DR   UCSC; uc008sqv.1; mouse.
DR   CTD; 51754; -.
DR   MGI; MGI:2441680; Tmem8b.
DR   eggNOG; ENOG410IHJ3; Eukaryota.
DR   eggNOG; ENOG4111FA8; LUCA.
DR   GeneTree; ENSGT00940000157861; -.
DR   HOGENOM; HOG000049225; -.
DR   InParanoid; B1AWJ5; -.
DR   OrthoDB; 704708at2759; -.
DR   PhylomeDB; B1AWJ5; -.
DR   TreeFam; TF331003; -.
DR   PRO; PR:B1AWJ5; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000078716; Expressed in 208 organ(s), highest expression level in brain.
DR   ExpressionAtlas; B1AWJ5; baseline and differential.
DR   Genevisible; B1AWJ5; MM.
DR   GO; GO:0009986; C:cell surface; ISO:MGI.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0007160; P:cell-matrix adhesion; ISO:MGI.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR021910; NGX6/PGAP6/MYMK.
DR   PANTHER; PTHR14319; PTHR14319; 1.
DR   Pfam; PF12036; DUF3522; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell membrane; Complete proteome; Cytoplasm;
KW   Disulfide bond; EGF-like domain; Endoplasmic reticulum; Glycoprotein;
KW   Growth regulation; Membrane; Mitochondrion; Nucleus;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    472       Transmembrane protein 8B.
FT                                /FTId=PRO_0000333040.
FT   TOPO_DOM      1    233       Extracellular. {ECO:0000255}.
FT   TRANSMEM    234    254       Helical. {ECO:0000255}.
FT   TOPO_DOM    255    257       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    258    277       Helical. {ECO:0000255}.
FT   TOPO_DOM    278    292       Extracellular. {ECO:0000255}.
FT   TRANSMEM    293    313       Helical. {ECO:0000255}.
FT   TOPO_DOM    314    315       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    316    336       Helical. {ECO:0000255}.
FT   TOPO_DOM    337    342       Extracellular. {ECO:0000255}.
FT   TRANSMEM    343    363       Helical. {ECO:0000255}.
FT   TOPO_DOM    364    379       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    380    400       Helical. {ECO:0000255}.
FT   TOPO_DOM    401    405       Extracellular. {ECO:0000255}.
FT   TRANSMEM    406    426       Helical. {ECO:0000255}.
FT   TOPO_DOM    427    472       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      182    221       EGF-like.
FT   CARBOHYD    100    100       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    186    196       {ECO:0000250}.
FT   DISULFID    190    209       {ECO:0000250}.
FT   DISULFID    211    220       {ECO:0000250}.
SQ   SEQUENCE   472 AA;  52114 MW;  7CA09DD6D1676DDE CRC64;
     MNMPQSLGTQ PLPPEPPSLG TPIEGSGAIA PTEHCWPVRP TLRNELDTFS VHFYIFFGPS
     VALPPERPAV FALRLLPVLD SGGVLSLELQ LNASSLRQEN VTVFGCLTHE VPLSLGDAAV
     TCSKESLAGF LLSVSATSRV ARLRIPFPQT GTWFLTLRSL CGVGPRFVRC RNATAEVRLR
     TFLSPCVDDC GPYGQCKLLR THNYLYAACE CKAGWRGWGC TDSADALTYG FQLLSTLLLC
     LSNLMFLPPV VLAIRSRYVL EAAVYTFTMF FSTFYHACDQ PGIVVFCIMD YDVLQFCDFL
     GSLMSVWVTV IAMARLQPVI KQVLYLLGAM LLSMALQLDR HGLWNLLGPS LFALGILATA
     WTVRSVRRRH CYPPTWRRWL FYLCPGSLIA GSAVLLYAFV ETRDNYFYIH SIWHMLIAGS
     VGFLLPPRAK TDRRVPSGAR ARGCGYQLCI NEQEELGLVG PGGTTVSSIC VS
//
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