ID B1AYU4_MOUSE Unreviewed; 723 AA.
AC B1AYU4;
DT 08-APR-2008, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Pre-mRNA-splicing factor CWC22 homolog {ECO:0000256|ARBA:ARBA00040488};
DE AltName: Full=Nucampholin homolog {ECO:0000256|ARBA:ARBA00042174};
GN Name=Cwc22 {ECO:0000313|Ensembl:ENSMUSP00000107455.2,
GN ECO:0000313|MGI:MGI:2136773};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000107455.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000107455.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000107455.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000107455.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000107455.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the CWC22 family.
CC {ECO:0000256|ARBA:ARBA00006856}.
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DR AlphaFoldDB; B1AYU4; -.
DR SMR; B1AYU4; -.
DR jPOST; B1AYU4; -.
DR MaxQB; B1AYU4; -.
DR PeptideAtlas; B1AYU4; -.
DR ProteomicsDB; 359514; -.
DR Ensembl; ENSMUST00000111824.8; ENSMUSP00000107455.2; ENSMUSG00000027014.15.
DR UCSC; uc008kgg.1; mouse.
DR AGR; MGI:2136773; -.
DR MGI; MGI:2136773; Cwc22.
DR VEuPathDB; HostDB:ENSMUSG00000027014; -.
DR GeneTree; ENSGT00940000153458; -.
DR HOGENOM; CLU_006308_2_1_1; -.
DR ChiTaRS; Cwc22; mouse.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000027014; Expressed in epiblast (generic) and 133 other cell types or tissues.
DR ExpressionAtlas; B1AYU4; baseline and differential.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR18034; CELL CYCLE CONTROL PROTEIN CWF22-RELATED; 1.
DR PANTHER; PTHR18034:SF3; PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51366; MI; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:B1AYU4,
KW ECO:0007829|MaxQB:B1AYU4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 453..569
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..436
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 82753 MW; 5DA67D3BE376472C CRC64;
MKSSVAHMKS SGHNRRETHS SYRRSSSPED RYTEQERSPR DRGYSDYSRS DYERSRRGYS
YDDSMESRSR DREKRRERER DADHRKRSRK SPSPDRSPAR GGGQSSPQEE PTWKKKKDEL
DPLLTRTGGA YIPPAKLRMM QEQITDKSSL AYQRMSWEAL KKSINGLINK VNISNISIII
QELLQENIVR GRGLLSRSVL QAQSASPIFT HVYAALVAII NSKFPQIGEL ILKRLILNFR
KGYRRNDKQL CLTASKFVAH LINQNVAHEV LCLEMLTLLL ERPTDDSVEV AIGFLKECGL
KLTQVSPRGI NAIFERLRNI LHESEIDKRV QYMIEVMFAV RKDGFKDHPV ILEGLDLVEE
DDQFTHMLPL EDDYNPEDVL NVFKMDPNFM ENEEKYKAIK KEILDEGDSD SNTDQGAGSS
EDEEEEDEEE EGEDEEGGQK VTIHDKTEIN LVSFRRTIYL AIQSSLDFEE CAHKLLKMEF
AESQTKELCN MILDCCAQQR TYEKFFGLLA GRFCMLKKEY MESFESIFKE QYDTIHRLET
NKLRNVAKMF AHLLYTDSLP WSVLECIKLS EETTTSSSRI FVKIFFQELC EYMGLPKLNA
RLKDETLQPF FEGLLPRDNP RNTRFAINFF TSIGLGGLTD ELREHLKNTP KVIVAQKPEA
EQKKPALTSS SSESSSASDS SDSESDSSES SSESSSDASD SSSSSSTQSS TSVSENTRRL
RAC
//
