ID B1H1G9_DANRE Unreviewed; 270 AA.
AC B1H1G9; A0A8M1NIA0;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
GN Name=tspan17 {ECO:0000313|Ensembl:ENSDARP00000157611,
GN ECO:0000313|RefSeq:NP_001116517.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-3673};
GN Synonyms=fc49c03 {ECO:0000313|RefSeq:NP_001116517.1}, wu:fc49c03
GN {ECO:0000313|RefSeq:NP_001116517.1};
GN ORFNames=zgc:158284 {ECO:0000313|EMBL:AAI60601.1,
GN ECO:0000313|RefSeq:NP_001116517.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI60601.1};
RN [1] {ECO:0000313|EMBL:AAI60601.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000313|EMBL:AAI60601.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001116517.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23598338; DOI=10.1038/nature12027;
RA Amemiya C.T., Alfoldi J., Lee A.P., Fan S., Philippe H., Maccallum I.,
RA Braasch I., Manousaki T., Schneider I., Rohner N., Organ C., Chalopin D.,
RA Smith J.J., Robinson M., Dorrington R.A., Gerdol M., Aken B.,
RA Biscotti M.A., Barucca M., Baurain D., Berlin A.M., Blatch G.L.,
RA Buonocore F., Burmester T., Campbell M.S., Canapa A., Cannon J.P.,
RA Christoffels A., De Moro G., Edkins A.L., Fan L., Fausto A.M., Feiner N.,
RA Forconi M., Gamieldien J., Gnerre S., Gnirke A., Goldstone J.V., Haerty W.,
RA Hahn M.E., Hesse U., Hoffmann S., Johnson J., Karchner S.I., Kuraku S.,
RA Lara M., Levin J.Z., Litman G.W., Mauceli E., Miyake T., Mueller M.G.,
RA Nelson D.R., Nitsche A., Olmo E., Ota T., Pallavicini A., Panji S.,
RA Picone B., Ponting C.P., Prohaska S.J., Przybylski D., Saha N.R., Ravi V.,
RA Ribeiro F.J., Sauka-Spengler T., Scapigliati G., Searle S.M., Sharpe T.,
RA Simakov O., Stadler P.F., Stegeman J.J., Sumiyama K., Tabbaa D., Tafer H.,
RA Turner-Maier J., van Heusden P., White S., Williams L., Yandell M.,
RA Brinkmann H., Volff J.N., Tabin C.J., Shubin N., Schartl M., Jaffe D.B.,
RA Postlethwait J.H., Venkatesh B., Di Palma F., Lander E.S., Meyer A.,
RA Lindblad-Toh K.;
RT "The African coelacanth genome provides insights into tetrapod evolution.";
RL Nature 496:311-316(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000157611, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000157611};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_001116517.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000157611}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000157611};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:NP_001116517.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361218}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361218}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC {ECO:0000256|ARBA:ARBA00006840, ECO:0000256|RuleBase:RU361218}.
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DR EMBL; CABZ01072359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01072360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01072361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LO018188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LO018396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC160601; AAI60601.1; -; mRNA.
DR RefSeq; NP_001116517.1; NM_001123045.1.
DR STRING; 7955.ENSDARP00000157611; -.
DR Ensembl; ENSDART00000192515.1; ENSDARP00000157611.1; ENSDARG00000114067.1.
DR GeneID; 324950; -.
DR KEGG; dre:324950; -.
DR AGR; ZFIN:ZDB-GENE-030131-3673; -.
DR CTD; 26262; -.
DR ZFIN; ZDB-GENE-030131-3673; tspan17.
DR OMA; DWNPSRE; -.
DR OrthoDB; 2879418at2759; -.
DR Proteomes; UP000000437; Chromosome 14.
DR Bgee; ENSDARG00000114067; Expressed in mature ovarian follicle and 21 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03159; TM4SF9_like_LEL; 1.
DR Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; TETRASPANIN; 1.
DR PANTHER; PTHR19282:SF470; TETRASPANIN-17; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR PRINTS; PR00259; TMFOUR.
DR SUPFAM; SSF48652; Tetraspanin; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361218};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|RuleBase:RU361218};
KW Transmembrane helix {ECO:0000256|RuleBase:RU361218}.
FT TRANSMEM 20..44
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 64..86
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 98..117
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 235..260
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
SQ SEQUENCE 270 AA; 30525 MW; 795C418A49D0506A CRC64;
MSRKQHHFKG AEVSCCVKYF LFGFNIIFWL LGAAFLGIGL WAWAEKGVLS NISSITDLGG
FDPVWLFIVV GGVMFILGFA GCIGALRENT FLLKFFSVFL GLIFFLELTA GILAFVFKDW
IKDQLNFFIN NNVKAYRDDI DLQNLIDFAQ EYWSCCGAHG PNDWNLNIYF NCTDFNPSRE
RCGVPFSCCV KDPAEDVLNT QCGYDVRLQV ELDQQKYIYT KGCVGQFEKW LQDNLIVVAG
VFVGIALLQI FGICLAQNLV SDIRAVKANW
//
