ID MUTS_BURO0 Reviewed; 885 AA.
AC B1JUW8;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=Bcenmc03_2107;
OS Burkholderia orbicola (strain MC0-3).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex;
OC Burkholderia orbicola.
OX NCBI_TaxID=406425;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC0-3;
RA Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L.,
RA Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S.,
RA Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome 1 of Burkholderia cenocepacia MC0-3.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000958; ACA91268.1; -; Genomic_DNA.
DR RefSeq; WP_012328801.1; NC_010508.1.
DR AlphaFoldDB; B1JUW8; -.
DR SMR; B1JUW8; -.
DR GeneID; 83048891; -.
DR KEGG; bcm:Bcenmc03_2107; -.
DR HOGENOM; CLU_002472_4_0_4; -.
DR Proteomes; UP000002169; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..885
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_1000093610"
FT BINDING 626..633
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 885 AA; 95969 MW; D53703D1FE54E91B CRC64;
MTTLSPEAFA GHTPMMQQYL RIKADHPDTL VFYRMGDFYE LFFEDAEKAA RLLDLTLTQR
GASAGTPIKM AGVPHHAVEQ YLAKLVKMGE SVAICEQIGD PATSKGPVER KVVRVVTPGT
LTDAALLSDK NDVYLLAMCT GHNKRGVAVN IGLAWLNLAS GALRLAEIEP DQLAAALERI
RPAEILTPDG ATDAIPAGAG ASKRVPAWHF DIASGTQRLC DQLDVASLDG FGAHSLTSAC
GAAGALLLYA AATQGQQLRH VRSLKVENET EYIGLDPATR RNLELTETLR GTESPTLYSL
LDTCCTTMGS RLLRHWLHHP PRASVAAQSR QQAIGALLDA PANASLDALR SALRQIADVE
RITGRLALLS ARPRDLSSLR DTFAALPALR ERISAIVANA DALARVDAAL APPAECLDLL
TSAIAPEPAA MVRDGGVIAR GYDAELDELR DISENCGQFL IDLEARERAR TGIANLRVEY
NKVHGFYIEV TRGQTDKVPD DYRRRQTLKN AERYITPELK TFEDKALSAQ ERALARERAL
YDSVLQALLP FIPECQRVAS ALAELDLLAA FAERARALDW VAPTFTDEIG IEIEQGRHPV
VEAQVEQFIA NDCRFGTERK LLLITGPNMG GKSTFMRQTA LIALMAYVGS YVPAKSACFG
PIDRIFTRIG AADDLAGGRS TFMVEMTEAA AILNDATPQS LVLMDEIGRG TSTFDGLALA
WAIARHLLAH NACYTLFATH YFELTQLPAE FPQAANVHLS AVEHGHGIVF LHAVNEGPAN
QSYGLQVAQL AGVPAPVIRA ARKHLAYLEQ QSASQHTPQL DLFSAPPAAV DDLECADAPA
LPDTPHPALE KLRDIDPDDL KPREALDLLY ELRTLVRSHD ADGHA
//
