ID B1KDG2_SHEWM Unreviewed; 1042 AA.
AC B1KDG2;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Heavy metal efflux pump, CzcA family {ECO:0000313|EMBL:ACA84963.1};
GN OrderedLocusNames=Swoo_0667 {ECO:0000313|EMBL:ACA84963.1};
OS Shewanella woodyi (strain ATCC 51908 / MS32).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=392500 {ECO:0000313|EMBL:ACA84963.1, ECO:0000313|Proteomes:UP000002168};
RN [1] {ECO:0000313|EMBL:ACA84963.1, ECO:0000313|Proteomes:UP000002168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51908 / MS32 {ECO:0000313|Proteomes:UP000002168};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Lykidis A., Zhao J.-S., Richardson P.;
RT "Complete sequence of Shewanella woodyi ATCC 51908.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR EMBL; CP000961; ACA84963.1; -; Genomic_DNA.
DR RefSeq; WP_012323310.1; NC_010506.1.
DR AlphaFoldDB; B1KDG2; -.
DR STRING; 392500.Swoo_0667; -.
DR KEGG; swd:Swoo_0667; -.
DR eggNOG; COG3696; Bacteria.
DR HOGENOM; CLU_002755_1_2_6; -.
DR Proteomes; UP000002168; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002168};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 345..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 879..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 905..924
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 930..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 976..996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1008..1034
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1042 AA; 113443 MW; 9773F745C6E00D8B CRC64;
MDTIISFALK RRWLVLTVTL LIALLGGYNT LKLPIDAVPD ITNVQVQINT AVAGYSPLES
EQRLTYVIEN AMAGIPNLDH TRSISRYGLS QITVIFEEGT DIYWARQQIA ERLQGIRGEL
PAEAEPALGP VSSGLGEVFT YSIRALDGAL KEDGTAYSAE DLRTIQDWII RPQLVKVPGV
TEINSLGGYE REYQVAPDPG KLLAFKVTVN DVITALERNN RNVGAGYIER NGEQWLVRSP
GQLKDLEEIR QVVVTKRDDA PVRIGDLAEV FYGKQLRTGS ATQNGEETVL GTAFMLLGEN
SRVVAKEVGD KLKEVNASLP DGIVAEAVYD RTSLVDQTIA TVQKNLFEGA VLVIVVLFAL
LGNFRAALIA ALVIPLSMLF AITGMTTNRV SGNLMSLGAI DFGIIVDGAV IIVENALRRL
GMAQKQHGRL LTLEERLKLV FEATREVFRP AVFGVLIIML VYLPIFALSG VEGKMFHPMA
FTVVAALIGA LIFSVTFVPA AIAIFVKGKV NEKENFLMAR ARSVYEPVLF FSLKRPAIIL
LAAAALMSVS LYQVSRLGSE FLPKLDEGDI AMHAMRITGT GLEQSTQMQK ELELVIAELD
EVERVFSKIG TPEVATDPMP PSVSDTILII KPRSQWADPS KSKAQFMDEL RDLVKQVPGN
NYEFTQPIEM RFNELIAGVR ADVALRIYGD DLDTLKAAGD RAQALFHKID GAKDVRVEQM
SGLPTLSVEP NRDHLALLGL TIVDVQQALQ SAVSGVPVGL IYEGDRRFKL VVRMKDEISH
DLRALEKLPI ALPADLNPDL SYVPLGEVAD IRFKVGPNQI NRQSGKRHVV VTANVEGRDL
GSFIQDTKAL MGDELNLPSG YWSEYGGTFE QLESASNRLM ILVPLTLLLI FGLLYSAFGS
VRDSLIIFSG VPLALTGGVL ALVLRDMPLS ISAAVGFIAL SGIAVLNGVV MLSFIKELKH
KGLALVDAIK QGASQRLRPV MMTALVASLG FVPMAFNVGT GAEVQRPLAT VVIGGIVSST
LLTLVILPVL YLLVYRISGK RA
//
