ID B1L3P1_KORCO Unreviewed; 330 AA.
AC B1L3P1;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Threonine dehydrogenase-related Zn-dependent dehydrogenase {ECO:0000313|EMBL:ACB07070.1};
GN OrderedLocusNames=Kcr_0312 {ECO:0000313|EMBL:ACB07070.1};
OS Korarchaeum cryptofilum (strain OPF8).
OC Archaea; Candidatus Korarchaeota; Korarchaeum.
OX NCBI_TaxID=374847 {ECO:0000313|EMBL:ACB07070.1, ECO:0000313|Proteomes:UP000001686};
RN [1] {ECO:0000313|EMBL:ACB07070.1, ECO:0000313|Proteomes:UP000001686}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OPF8 {ECO:0000313|Proteomes:UP000001686};
RX PubMed=18535141; DOI=10.1073/pnas.0801980105;
RA Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L.,
RA Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A.,
RA Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G.,
RA Richardson P., Keller M., Stetter K.O.;
RT "A korarchaeal genome reveals new insights into the evolution of the
RT Archaea.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000968; ACB07070.1; -; Genomic_DNA.
DR AlphaFoldDB; B1L3P1; -.
DR STRING; 374847.Kcr_0312; -.
DR EnsemblBacteria; ACB07070; ACB07070; Kcr_0312.
DR KEGG; kcr:Kcr_0312; -.
DR eggNOG; arCOG01459; Archaea.
DR HOGENOM; CLU_026673_11_0_2; -.
DR InParanoid; B1L3P1; -.
DR PhylomeDB; B1L3P1; -.
DR Proteomes; UP000001686; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR GO; GO:0044282; P:small molecule catabolic process; IEA:UniProt.
DR CDD; cd08242; MDR_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR031640; Glu_dehyd_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43350:SF17; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF16912; Glu_dehyd_C; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001686};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 169..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..136
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 167..328
FT /note="Glucose dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16912"
SQ SEQUENCE 330 AA; 35946 MW; 0C3028FB6A0366E9 CRC64;
MGINSAMRAL VLHAPRDLRL EDVDERSPGN GWVKVRVRRV GICGTDKSIY LGDYAARKLP
IILGHEISGE IVEVGEGVDE RIIGQRVTSE INLSCGECSF CKRGLREHCL RREALGISLD
GGMAEYVLTR ADLIHPIGDL SWLQGAFIEP LAAALKPFFL MPPPPSSSIA VVGVGTIGLL
SVQISALFAP KRLVAISRRR GRKSELAEIF GAESMTVEEA LNLKGEFDLV IEASGSPNGL
EIALNLTRPR GTIFAKSTHG KEVSFDYTRA VVNEITILGS RCGPFDAAIE LLRKGKVRVD
ELVTSVYKLE DGVEAFIRSL DPDELKVQLE
//
