ID B1L4S5_KORCO Unreviewed; 315 AA.
AC B1L4S5;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Ribonuclease {ECO:0000256|RuleBase:RU003515};
DE EC=3.1.26.4 {ECO:0000256|RuleBase:RU003515};
GN OrderedLocusNames=Kcr_0703 {ECO:0000313|EMBL:ACB07454.1};
OS Korarchaeum cryptofilum (strain OPF8).
OC Archaea; Candidatus Korarchaeota; Korarchaeum.
OX NCBI_TaxID=374847 {ECO:0000313|EMBL:ACB07454.1, ECO:0000313|Proteomes:UP000001686};
RN [1] {ECO:0000313|EMBL:ACB07454.1, ECO:0000313|Proteomes:UP000001686}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OPF8 {ECO:0000313|Proteomes:UP000001686};
RX PubMed=18535141; DOI=10.1073/pnas.0801980105;
RA Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L.,
RA Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A.,
RA Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G.,
RA Richardson P., Keller M., Stetter K.O.;
RT "A korarchaeal genome reveals new insights into the evolution of the
RT Archaea.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008).
CC -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA
CC hybrids. {ECO:0000256|RuleBase:RU003515}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077,
CC ECO:0000256|RuleBase:RU003515};
CC -!- SIMILARITY: Belongs to the RNase HII family.
CC {ECO:0000256|RuleBase:RU003515}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01319}.
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DR EMBL; CP000968; ACB07454.1; -; Genomic_DNA.
DR RefSeq; WP_012309351.1; NC_010482.1.
DR AlphaFoldDB; B1L4S5; -.
DR STRING; 374847.Kcr_0703; -.
DR EnsemblBacteria; ACB07454; ACB07454; Kcr_0703.
DR GeneID; 6093985; -.
DR KEGG; kcr:Kcr_0703; -.
DR eggNOG; arCOG04116; Archaea.
DR eggNOG; arCOG04121; Archaea.
DR HOGENOM; CLU_881697_0_0_2; -.
DR InParanoid; B1L4S5; -.
DR OrthoDB; 33866at2157; -.
DR PhylomeDB; B1L4S5; -.
DR Proteomes; UP000001686; Chromosome.
DR GO; GO:0032299; C:ribonuclease H2 complex; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IBA:GO_Central.
DR GO; GO:0043137; P:DNA replication, removal of RNA primer; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 1.10.10.460; Ribonuclease hii. Domain 2; 1.
DR InterPro; IPR001352; RNase_HII/HIII.
DR InterPro; IPR024567; RNase_HII/HIII_dom.
DR InterPro; IPR023160; RNase_HII_hlx-loop-hlx_cap_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10954; RIBONUCLEASE H2 SUBUNIT A; 1.
DR PANTHER; PTHR10954:SF7; RIBONUCLEASE H2 SUBUNIT A; 1.
DR Pfam; PF01351; RNase_HII; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51975; RNASE_H_2; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759,
KW ECO:0000256|RuleBase:RU003515};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003515};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|RuleBase:RU003515};
KW Reference proteome {ECO:0000313|Proteomes:UP000001686}.
FT DOMAIN 1..161
FT /note="RNase H type-2"
FT /evidence="ECO:0000259|PROSITE:PS51975"
SQ SEQUENCE 315 AA; 36145 MW; 8D820B793FBF662B CRC64;
MKHGFRYEVQ TISPEEVDEY NLNKIMDVTY QRILSKFTRD ADMRSCRVVL DDYGVGSTLG
RYLNFLRNQG AEVIVENKAD ERYLEVKVAS LVSKRIREEI IERINENPDF QIDGLSVGSG
NPNDMQTIKW LEKWYESGRD WPWFIRRSYE TVRRIEGKPE RSKQIPPIKE ELLSEEFLEE
FNKGRLSIQS LAIICPHCGS INKSVTFAIY EDDGRKISGI KCPKCKKLIE NAGITLRYYC
GYVVPDTNIV IRGVISKDLE SSRFFEGFTI ILPNVVRKEA DNKKGKQELG KLAELSSIGR
IGLECPGKVE GISKI
//
