GenomeNet

Database: UniProt
Entry: B1L765
LinkDB: B1L765
Original site: B1L765 
ID   GYAR_KORCO              Reviewed;         332 AA.
AC   B1L765;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   16-JAN-2019, entry version 67.
DE   RecName: Full=Glyoxylate reductase {ECO:0000255|HAMAP-Rule:MF_00776};
DE            EC=1.1.1.26 {ECO:0000255|HAMAP-Rule:MF_00776};
GN   Name=gyaR {ECO:0000255|HAMAP-Rule:MF_00776};
GN   OrderedLocusNames=Kcr_1548;
OS   Korarchaeum cryptofilum (strain OPF8).
OC   Archaea; Candidatus Korarchaeota; Candidatus Korarchaeum.
OX   NCBI_TaxID=374847;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OPF8;
RX   PubMed=18535141; DOI=10.1073/pnas.0801980105;
RA   Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L.,
RA   Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A.,
RA   Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N.,
RA   Wanner G., Richardson P., Keller M., Stetter K.O.;
RT   "A korarchaeal genome reveals new insights into the evolution of the
RT   Archaea.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycolate + NAD(+) = glyoxylate + H(+) + NADH;
CC         Xref=Rhea:RHEA:18229, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805,
CC         ChEBI:CHEBI:36655, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=1.1.1.26; Evidence={ECO:0000255|HAMAP-Rule:MF_00776};
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00776}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00776}.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. GyaR subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00776}.
DR   EMBL; CP000968; ACB08294.1; -; Genomic_DNA.
DR   RefSeq; WP_012310191.1; NC_010482.1.
DR   ProteinModelPortal; B1L765; -.
DR   SMR; B1L765; -.
DR   STRING; 374847.Kcr_1548; -.
DR   PRIDE; B1L765; -.
DR   EnsemblBacteria; ACB08294; ACB08294; Kcr_1548.
DR   GeneID; 6094825; -.
DR   KEGG; kcr:Kcr_1548; -.
DR   eggNOG; arCOG01755; Archaea.
DR   eggNOG; COG1052; LUCA.
DR   HOGENOM; HOG000136700; -.
DR   InParanoid; B1L765; -.
DR   KO; K00015; -.
DR   OMA; KWIAHNG; -.
DR   OrthoDB; 36410at2157; -.
DR   BioCyc; CKOR374847:G1GBF-1634-MONOMER; -.
DR   Proteomes; UP000001686; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0030267; F:glyoxylate reductase (NADP) activity; IBA:GO_Central.
DR   GO; GO:0047964; F:glyoxylate reductase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016618; F:hydroxypyruvate reductase activity; IBA:GO_Central.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   HAMAP; MF_00776; GyaR; 1.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR023519; Glyoxylate_reductase_GyaR.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; NAD; Oxidoreductase; Reference proteome.
FT   CHAIN         1    332       Glyoxylate reductase.
FT                                /FTId=PRO_0000348415.
FT   NP_BIND     155    158       NADP. {ECO:0000255|HAMAP-Rule:MF_00776}.
FT   NP_BIND     236    238       NADP. {ECO:0000255|HAMAP-Rule:MF_00776}.
FT   NP_BIND     286    288       NADP. {ECO:0000255|HAMAP-Rule:MF_00776}.
FT   ACT_SITE    238    238       {ECO:0000255|HAMAP-Rule:MF_00776}.
FT   ACT_SITE    267    267       {ECO:0000255|HAMAP-Rule:MF_00776}.
FT   ACT_SITE    286    286       Proton donor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00776}.
SQ   SEQUENCE   332 AA;  37477 MW;  4A4A0FCA2D144207 CRC64;
     MKPRVFVTRE IPERGLSKIE EHFELDLWKD EAPPSKKVII ERVKDCDALV SLLTDPIDAE
     VFEAAPKLRI VAQYAVGYDN IDVKEATKRG IYVTNTPGVL TETTADFAFA LLMAAARRVV
     EADRYVREGK WKVAWHPMMM LGYDVYGRTL GIVGMGRIGA AVARRAKGFG MRILYYDSIR
     REDFEKELGV EYVPLEKLLE ESDFVSLHVP LTEETYHMIG EEQLRRMKRT AILVNTSRGK
     VVDQKALYKA LKEGWIAGAG LDVFEQEPIP PDDPLLKLEN VVLAPHAASA SHETRSRMAE
     MVAENLIAFK RGEIPPNLVN QEVVKVRPPG FQ
//
DBGET integrated database retrieval system