ID B1LSK7_METRJ Unreviewed; 503 AA.
AC B1LSK7;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=Blue-light-activated histidine kinase {ECO:0000256|ARBA:ARBA00021740};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Mrad2831_3331 {ECO:0000313|EMBL:ACB25309.1};
OS Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS NBRC 15690 / NCIMB 10815 / 0-1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=426355 {ECO:0000313|EMBL:ACB25309.1, ECO:0000313|Proteomes:UP000006589};
RN [1] {ECO:0000313|EMBL:ACB25309.1, ECO:0000313|Proteomes:UP000006589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 /
RC 0-1 {ECO:0000313|Proteomes:UP000006589};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Marx C.J., Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT 2831.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001001; ACB25309.1; -; Genomic_DNA.
DR AlphaFoldDB; B1LSK7; -.
DR STRING; 426355.Mrad2831_3331; -.
DR KEGG; mrd:Mrad2831_3331; -.
DR PATRIC; fig|426355.14.peg.3404; -.
DR eggNOG; COG2202; Bacteria.
DR eggNOG; COG3920; Bacteria.
DR HOGENOM; CLU_000445_114_57_5; -.
DR Proteomes; UP000006589; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 2.10.70.100; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR011102; Sig_transdc_His_kinase_HWE.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR41523:SF7; ETHYLENE RESPONSE SENSOR PROTEIN; 1.
DR PANTHER; PTHR41523; TWO-COMPONENT SYSTEM SENSOR PROTEIN; 1.
DR Pfam; PF07536; HWE_HK; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00911; HWE_HK; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50113; PAC; 2.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACB25309.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 28..77
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 102..156
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 175..246
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 249..301
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT COILED 144..178
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 503 AA; 56488 MW; 7398AC3C6116FEF8 CRC64;
MSWQGRRALT DQQERTRFEA EFARTDASTD PFVSAVRATR MPMLITDPHQ PDNPIVFVNA
AFSKLTGYRH DEIIGRNCRF LQGAETNKAD IAKIRAAIAR RVPIEIELLN HKKSGEVFWN
RLLISPVFDR DGELTYFFAS QFDVTLEREK LARMQRDREA LEREVERRTG DLTRSEERLR
FILKAGRFGS WTLDLADMRL VASDACKENF GRAPGEPFSY EDLIAAIDPE DRPRMQAAVQ
TSIREHSDYD IEYRARTPGG ELRWLQIRGQ TFYDSVGQPL SMAGVSIDVT ERKRAEEHRT
LLADELNHRV KNSMATMQSI AHQTLRNAAS LEEAHRTLDA RLHSLSAAHD VLTRESWIGA
TLNVIVEGTL QAFRGGASQR FLINGPDVWL TPRLTLAFTM ALHELATNAV KYGALSNDRG
RVILNWDVVD GATPAHLWFR WEEVGGPAVT APARGGFGTR LIERALAAEM GGSAEIEYRA
HGVVFTLNAP LPDRAPAAAE AKA
//
