ID B1LX70_METRJ Unreviewed; 571 AA.
AC B1LX70;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Mrad2831_5235 {ECO:0000313|EMBL:ACB27191.1};
OS Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS NBRC 15690 / NCIMB 10815 / 0-1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=426355 {ECO:0000313|EMBL:ACB27191.1, ECO:0000313|Proteomes:UP000006589};
RN [1] {ECO:0000313|EMBL:ACB27191.1, ECO:0000313|Proteomes:UP000006589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 /
RC 0-1 {ECO:0000313|Proteomes:UP000006589};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Marx C.J., Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT 2831.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001001; ACB27191.1; -; Genomic_DNA.
DR RefSeq; WP_012322135.1; NC_010505.1.
DR AlphaFoldDB; B1LX70; -.
DR STRING; 426355.Mrad2831_5235; -.
DR KEGG; mrd:Mrad2831_5235; -.
DR PATRIC; fig|426355.14.peg.5297; -.
DR eggNOG; COG3850; Bacteria.
DR eggNOG; COG3920; Bacteria.
DR HOGENOM; CLU_023848_1_0_5; -.
DR OrthoDB; 341208at2; -.
DR Proteomes; UP000006589; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd12914; PDC1_DGC_like; 1.
DR CDD; cd12915; PDC2_DGC_like; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR011102; Sig_transdc_His_kinase_HWE.
DR PANTHER; PTHR41523:SF7; ETHYLENE RESPONSE SENSOR PROTEIN; 1.
DR PANTHER; PTHR41523; TWO-COMPONENT SYSTEM SENSOR PROTEIN; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF07536; HWE_HK; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00911; HWE_HK; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACB27191.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..571
FT /note="histidine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002768316"
FT TRANSMEM 275..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 298..350
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT COILED 370..418
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 571 AA; 61501 MW; 5AEE238496F07D73 CRC64;
MLTRRILALV ALALAPALAI QGYNEYALRT SRDAAVRADA LGTARTVAAD LGQLAQSLRQ
VLDLVGNEEA VRRKDAGACT AYLGAIIDRL PQLSLLSVAE PDGRVVCDSR GSTPGLYSNA
ERAYHKRVLA SDDFAVGDFV IGVRTRQPAV HFAQPVRGYD DRLTGVVVAS VDLARLSERL
QADLRFASTT LTVTDPEGTV LVRRPDHAAW VGRKLSGERL ARLMRADETT RSVEGLDGRA
RIVGIAKPDG ALAGFNVIVG RDRETAFADI DAATYRGIAV ILLGALLAVL ATLLAGRRFI
ERPVRRLLRG VAAWQGGDLD ARTGMSGPSE FDRLGAAFDA MATTLQGRED DLHGEIARGR
RMQEQQTTML HELNHRVKNT LATVQSLARQ ARGGEEQAAQ LEARILALSK THDLLTREDW
TGASLRDVME NELSPYRTGD DHITLDGPDV PLPPRYALAI GMTVHELATN AAKYGALSDV
GGQVCVAWRL VHCEGGGRRL HLDWQESGGP RVEPPSRSGF GTRLIAGGMQ RELGGEVSLT
FDPTGLRCLL DVPLQGSHTS MLSPLADGLA H
//
