ID B1M1T0_METRJ Unreviewed; 680 AA.
AC B1M1T0;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Methylmalonyl-CoA mutase, large subunit {ECO:0000313|EMBL:ACB23115.1};
DE EC=5.4.99.2 {ECO:0000313|EMBL:ACB23115.1};
GN OrderedLocusNames=Mrad2831_1106 {ECO:0000313|EMBL:ACB23115.1};
OS Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS NBRC 15690 / NCIMB 10815 / 0-1).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=426355 {ECO:0000313|EMBL:ACB23115.1, ECO:0000313|Proteomes:UP000006589};
RN [1] {ECO:0000313|EMBL:ACB23115.1, ECO:0000313|Proteomes:UP000006589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 /
RC 0-1 {ECO:0000313|Proteomes:UP000006589};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Marx C.J., Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT 2831.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC Evidence={ECO:0000256|ARBA:ARBA00001922};
CC -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
CC {ECO:0000256|ARBA:ARBA00008465}.
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DR EMBL; CP001001; ACB23115.1; -; Genomic_DNA.
DR RefSeq; WP_012318107.1; NC_010505.1.
DR AlphaFoldDB; B1M1T0; -.
DR STRING; 426355.Mrad2831_1106; -.
DR KEGG; mrd:Mrad2831_1106; -.
DR PATRIC; fig|426355.14.peg.1150; -.
DR eggNOG; COG1884; Bacteria.
DR eggNOG; COG2185; Bacteria.
DR HOGENOM; CLU_009523_4_0_5; -.
DR OrthoDB; 9762378at2; -.
DR Proteomes; UP000006589; Chromosome.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IEA:UniProtKB-EC.
DR CDD; cd02071; MM_CoA_mut_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR InterPro; IPR006159; Acid_CoA_mut_C.
DR InterPro; IPR016176; Cbl-dep_enz_cat.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR InterPro; IPR006098; MMCoA_mutase_a_cat.
DR NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR NCBIfam; TIGR00641; acid_CoA_mut_N; 1.
DR PANTHER; PTHR48101:SF3; COENZYME B12-DEPENDENT MUTASE; 1.
DR PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF01642; MM_CoA_mutase; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ACB23115.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 533..662
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 680 AA; 74152 MW; D556A30949762B1D CRC64;
MGASVAETRS DKSSRDKPWI IRTYAGHSTA AESNKLYRGN LAKGQTGLSV AFDLPTQTGY
DPDHELSRGE VGKVGVSIAH LGDMRTLFQD IPLAQMNTSM TINATAPWLL ALYLAVAEEQ
GAPIAALQGT TQNDIIKEYL SRGTYVFPPA PSLRLTKDVI LFTTRNVPKW NPMNVCSYHL
QEAGATPVQE LSYALAIAIA VLDTVREDPE FDAASFPEVF GRISFFVNAG LRFVTEICKM
RAFSELWDEI ARERYGIDDP KKRIFRYGVQ VNSLGLTEQQ PENNVHRILI EMLAVTLSKR
ARARAVQLPA WNEALGLPRP WDQQWSMRMQ QILAFETDLL EYDDIFDGSH VIEAKVEELK
AQTRAELERI GGIGGAVAAV ETGALKRALV ESNARRISAI EAGEQIVVGV NKWQQGEPSP
LTAGEGAIFS VSETVEMEAQ SRIREWRGRR DENAVGQALD ALERAARSGT NIMPPSIEAA
KAGVTTGEWG ARLRAVFGEY RAPTGVTVET VSSGAAEEAK LLIADLGERL GETPKLVVGK
PGLDGHSNGA EQIALRARDV GFDVTYDGIR QTPAEIVAKA KETGAHVVGL SILSGSHVPL
VREVRAKMRE AGLDHIPVVV GGIISPEDEL VLKNMGVRAV YTPKDYAIDQ IMVGLAKVVE
KGLERRDGPS NQPRAEAQVY
//
