ID   B1M266_METRJ            Unreviewed;       960 AA.
AC   B1M266;
DT   29-APR-2008, integrated into UniProtKB/TrEMBL.
DT   29-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) {ECO:0000313|EMBL:ACB24677.1};
GN   OrderedLocusNames=Mrad2831_2693 {ECO:0000313|EMBL:ACB24677.1};
OS   Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS   NBRC 15690 / NCIMB 10815 / 0-1).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=426355 {ECO:0000313|EMBL:ACB24677.1, ECO:0000313|Proteomes:UP000006589};
RN   [1] {ECO:0000313|EMBL:ACB24677.1, ECO:0000313|Proteomes:UP000006589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 /
RC   0-1 {ECO:0000313|Proteomes:UP000006589};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Marx C.J., Richardson P.;
RT   "Complete sequence of chromosome of Methylobacterium radiotolerans JCM
RT   2831.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001001; ACB24677.1; -; Genomic_DNA.
DR   RefSeq; WP_012319646.1; NC_010505.1.
DR   AlphaFoldDB; B1M266; -.
DR   STRING; 426355.Mrad2831_2693; -.
DR   KEGG; mrd:Mrad2831_2693; -.
DR   PATRIC; fig|426355.14.peg.2758; -.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_000445_70_20_5; -.
DR   OrthoDB; 9814202at2; -.
DR   Proteomes; UP000006589; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR44757:SF2; BIOFILM ARCHITECTURE MAINTENANCE PROTEIN MBAA; 1.
DR   PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF12860; PAS_7; 2.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        32..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        203..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          227..279
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          561..694
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          703..953
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   960 AA;  103890 MW;  B3265080E1DC9912 CRC64;
     MRDPETPTDC GDRAGRSRAA ATLTGRVTTI RAAVGVAFLC VALLLGALAL STGLAILQVG
     GLATRTYDES LTSISFARAA AADFAKMRTT LIRRMQARDG AEVAKRDSEI TDLSAVLAED
     LVIAAERAQS ERAARTAQAV QAGVASWESL RRELDPVTVR PDQAAALERQ ADAVEGQIDL
     LINVMAGDGF TFRQAARQRV VGAIRWHAAA VALVILACGL IAWLLTRRIS GSVSAAAEAA
     ERIAGGQLDD RIPTGGRDGL SRLLDAVAAM RSTIRALTLR EVSQRRVAEA LVTDALQTSR
     EGVVVVDADG RIALANAQAL RFFVGLDAAI EAGLSLTRIA DQPRDKHREV LDDCFRALAR
     DGDIRLADGR WLRVSRSATR QGGFIAVCSD ISVLKEQERR LTQTNLRLDA ALDTMSQGLC
     LYDGQSRLMV VNRRYSEIYG LPPGAVVPGM TALEVLSASL AAGNHPGCDL EALLRQQRDA
     FSNGAWQTHF QELSNGRIVA IDRREAADGG FVATYEDVTE RRRAEARIAF MAHHDMLTGL
     PNRVAVGQQI DVAVAQAGRD QGFAVFAIDL DDFRPVNETL GHGIGDELLV AVANRLTACV
     REIDCVARLG ADEFIVVQRG VDRPEDAAIL ARRIIEVVGA PYSLTHHTIS VGLTIGITLA
     PSDGSNADKL LKNAEVALDR GKTEARGAFR FFEPAMDARL IARRIMERDL RDALAREAFE
     VYYQPIYSLE TDRICGFEAL LRWNHPVRGF VSPAEFIPIA EELGLIVPLG EWVLRRACEE
     AARWPDELKV AVNVSAVQFT SASLVTAVRE ALRRTGLPGR RLELEITETV LVANPGATTA
     ILHSLRALGV RVAMDDFGTG YSSLSYLRSF PFDKIKIDQS FVRDLCVKDG TDFIVRAVIG
     LGASLGMTTT AEGVETEAQL AHLRAEGCDE VQGYLFSRPV PVSEVASVIR RWNGALRAIA
//