ID B1M8A8_METRJ Unreviewed; 717 AA.
AC B1M8A8;
DT 29-APR-2008, integrated into UniProtKB/TrEMBL.
DT 29-APR-2008, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Blue-light-activated histidine kinase {ECO:0000256|ARBA:ARBA00021740};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Mrad2831_5794 {ECO:0000313|EMBL:ACB27733.1};
OS Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 /
OS NBRC 15690 / NCIMB 10815 / 0-1).
OG Plasmid pMRAD01 {ECO:0000313|EMBL:ACB27733.1,
OG ECO:0000313|Proteomes:UP000006589}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=426355 {ECO:0000313|EMBL:ACB27733.1, ECO:0000313|Proteomes:UP000006589};
RN [1] {ECO:0000313|EMBL:ACB27733.1, ECO:0000313|Proteomes:UP000006589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 /
RC 0-1 {ECO:0000313|Proteomes:UP000006589};
RC PLASMID=Plasmid pMRAD01 {ECO:0000313|Proteomes:UP000006589};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Marx C.J., Richardson P.;
RT "Complete sequence of plasmid1 of Methylobacterium radiotolerans JCM
RT 2831.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001002; ACB27733.1; -; Genomic_DNA.
DR RefSeq; WP_012329530.1; NC_010510.1.
DR AlphaFoldDB; B1M8A8; -.
DR KEGG; mrd:Mrad2831_5794; -.
DR PATRIC; fig|426355.14.peg.5900; -.
DR eggNOG; COG2202; Bacteria.
DR eggNOG; COG3920; Bacteria.
DR eggNOG; COG4566; Bacteria.
DR HOGENOM; CLU_000445_114_44_5; -.
DR OrthoDB; 341208at2; -.
DR Proteomes; UP000006589; Plasmid pMRAD01.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 4.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR011102; Sig_transdc_His_kinase_HWE.
DR NCBIfam; TIGR00229; sensory_box; 3.
DR PANTHER; PTHR41523:SF7; ETHYLENE RESPONSE SENSOR PROTEIN; 1.
DR PANTHER; PTHR41523; TWO-COMPONENT SYSTEM SENSOR PROTEIN; 1.
DR Pfam; PF07536; HWE_HK; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF08448; PAS_4; 2.
DR Pfam; PF13188; PAS_8; 1.
DR SMART; SM00911; HWE_HK; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 4.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 4.
DR PROSITE; PS50113; PAC; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACB27733.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Plasmid {ECO:0000313|EMBL:ACB27733.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 349..401
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 475..528
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
SQ SEQUENCE 717 AA; 80180 MW; 90FCD24C3D852939 CRC64;
MAARIRDFAW ERTPLGPSAR WPERLKVMVE QVLASPLVAS LVCGPERLLI YNDAAARLYG
ARHPEGLGRP LARTFPEGWG TVAAFYARAF AGEAVQVAGQ PLDTRGAGAA EDVFDALLVP
VRDADGQVMA VHMTGFEIGE RLRTEAKLRM SEARYRHLFD AIDEGFCTIE VLVDAAGQAV
DYRFLSVNAA FEQQTGLSDA VGRTVRALAP DLERHWFETY GRIVRTGKAE RFEDRADALG
RWYEVYAFPI GAPERRQVGV LFKDILQRKR AEDRLRASEE RFRALVTASS DVIYRMSPDW
SELRVLEGRG FLVDTVTPND DWLSAYIDPA DQPRLREAIQ RAIRSKTMFE LEHPVRQADG
SLGWALSRAV PLLDDDGEIR EWFGAASDVT ARKRAEDDLR ASEERFRGLV EGFGQFSWEA
SAEGLIEADS PGWRAFTGQR LDEWLGRGWV HAIHADDRAL TEAKWRQAVA TRTAVDHEYR
LWHAPSASWR WSNVRAVPIT NPDGSIRKWS GVNIDVTDHH RLLARQEVLI NELQHRTRNL
LGVVSAVAGR TLREGSPVEA FEARLQALSR AQGLLSQYGS DTVEVGALVR AELAAYVDGA
AGRMTVAGPE VHLSARQVQN FALAVHELTT NAVKHGALKT GIGHLSVTWE IVRDRRERRR
LALSWIETGL PEQRARVTRR GYGTELIQEA LAYALGAKVD YALDRDGVRC RIEMPVS
//
