ID B1VMR4_STRGG Unreviewed; 452 AA.
AC B1VMR4;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN OrderedLocusNames=SGR_6710 {ECO:0000313|EMBL:BAG23539.1};
OS Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG23539.1, ECO:0000313|Proteomes:UP000001685};
RN [1] {ECO:0000313|EMBL:BAG23539.1, ECO:0000313|Proteomes:UP000001685}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX PubMed=18375553; DOI=10.1128/JB.00204-08;
RA Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA Yamashita A., Hattori M., Horinouchi S.;
RT "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT griseus IFO 13350.";
RL J. Bacteriol. 190:4050-4060(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
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DR EMBL; AP009493; BAG23539.1; -; Genomic_DNA.
DR RefSeq; WP_012382148.1; NC_010572.1.
DR AlphaFoldDB; B1VMR4; -.
DR GeneID; 6215319; -.
DR KEGG; sgr:SGR_6710; -.
DR PATRIC; fig|455632.4.peg.6885; -.
DR eggNOG; COG3486; Bacteria.
DR HOGENOM; CLU_020931_2_0_11; -.
DR Proteomes; UP000001685; Chromosome.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000313|EMBL:BAG23539.1};
KW Oxidoreductase {ECO:0000313|EMBL:BAG23539.1}.
SQ SEQUENCE 452 AA; 49777 MW; CD03EBCCFBD225BB CRC64;
MSQVLPGDTP LVHDLIGIGF GPSNVAMAIA LSEHNSKVGR QDSVTAHFFE QQSSFGWHRG
MLIDDATMQV SFLKDLVTLR NPASEFSFLC YLQSKGRLID FINHKNLFPL RVEFHDYFEW
AAAKVDDLVS YDHEVVAVAP YVHDGTVEYL DVTVRSGAGV AVHRARNLVI GTGLRPLMPE
GVERGERVWH NSDLLRKVDG LESGSPSRFV VVGAGQSAAE NVAYLHRRFP DAEVCAVFSR
YGYSPADDSS FANRIFDPDA VDDYFAAPEE VKSRLMAYHG NTNYSVVDID LIDDLYRQMY
REKVLGTERL RFLNVSRVTG VEETADGVRA TVRSLVTDEE SELDADVVVF ATGYSPADPL
GVLGEVGGSC RRDEAGRVRV ERDYRIVTDP ALRCGIYLQG GTEHTHGITT SLLSNTAIRV
GEILDSLLDR RVKSTSDESR PVAEGSGGAA PR
//