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Database: UniProt
Entry: B1WAU6_XENTR
LinkDB: B1WAU6_XENTR
Original site: B1WAU6_XENTR 
ID   B1WAU6_XENTR            Unreviewed;       552 AA.
AC   B1WAU6;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   08-MAY-2019, entry version 71.
DE   SubName: Full=Has2 protein {ECO:0000313|EMBL:AAI61505.1};
DE   SubName: Full=Hyaluronan synthase 2 {ECO:0000313|Ensembl:ENSXETP00000015027};
GN   Name=has2 {ECO:0000313|EMBL:AAI61505.1,
GN   ECO:0000313|Ensembl:ENSXETP00000015027,
GN   ECO:0000313|Xenbase:XB-GENE-5775581};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI61505.1};
RN   [1] {ECO:0000313|EMBL:AAI61505.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Whole embryo {ECO:0000313|EMBL:AAI61505.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000015027}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000015027};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [3] {ECO:0000313|Ensembl:ENSXETP00000015027}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
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DR   EMBL; AAMC01114103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC161505; AAI61505.1; -; mRNA.
DR   RefSeq; NP_001120557.1; NM_001127085.1.
DR   STRING; 8364.ENSXETP00000015027; -.
DR   CAZy; GT2; Glycosyltransferase Family 2.
DR   Ensembl; ENSXETT00000015027; ENSXETP00000015027; ENSXETG00000006863.
DR   GeneID; 100145711; -.
DR   KEGG; xtr:100145711; -.
DR   CTD; 3037; -.
DR   Xenbase; XB-GENE-5775581; has2.
DR   eggNOG; KOG2571; Eukaryota.
DR   eggNOG; COG1215; LUCA.
DR   GeneTree; ENSGT00390000010337; -.
DR   HOGENOM; HOG000112847; -.
DR   KO; K00752; -.
DR   OMA; TAYIMGY; -.
DR   OrthoDB; 332363at2759; -.
DR   TreeFam; TF332506; -.
DR   Reactome; R-XTR-2142850; Hyaluronan biosynthesis and export.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000006863; Expressed in 9 organ(s), highest expression level in gastrula.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0050501; F:hyaluronan synthase activity; ISS:UniProtKB.
DR   GO; GO:0036302; P:atrioventricular canal development; IEA:Ensembl.
DR   GO; GO:0003181; P:atrioventricular valve morphogenesis; IEA:Ensembl.
DR   GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR   GO; GO:0021535; P:cell migration in hindbrain; IEA:Ensembl.
DR   GO; GO:0060030; P:dorsal convergence; IEA:Ensembl.
DR   GO; GO:0085029; P:extracellular matrix assembly; IBA:GO_Central.
DR   GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IBA:GO_Central.
DR   GO; GO:0031101; P:fin regeneration; IEA:Ensembl.
DR   GO; GO:0003146; P:heart jogging; IEA:Ensembl.
DR   GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR   GO; GO:0030213; P:hyaluronan biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0008078; P:mesodermal cell migration; IEA:Ensembl.
DR   GO; GO:0035810; P:positive regulation of urine volume; ISS:UniProtKB.
DR   GO; GO:2000223; P:regulation of BMP signaling pathway involved in heart jogging; IEA:Ensembl.
DR   GO; GO:0070295; P:renal water absorption; ISS:UniProtKB.
DR   GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR   InterPro; IPR028371; HAS2.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR22913:SF7; PTHR22913:SF7; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     12     37       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     43     66       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    375    397       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    431    455       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    475    497       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    509    533       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   552 AA;  63549 MW;  8A3D704C7E5D7E10 CRC64;
     MHCERFICIL RIIGTTLFGV SLLLGISAAY IVGYQFIQTD NYYFSFGLYG AILALHLIIQ
     SLFAFLEHRK MKRSLETPIK LNKSVALCIA AYQEDPDYLR KCLLSVKRLT YPGMKVIMVI
     DGNSDDDLYM MDIFREIMGS DSCATYVWKN NFHLKGPNET DGSHRESMQH VTQMVLSNKN
     VCIMQKWGGK REVMYTAFKA LGRSVDYVQV CDSDTVLDPA SSVEMVKVLE EDIMVGGVGG
     DVQILNKYDS WISFLSSVRY WMAFNIERAC QSYFGCVQCI SGPLGMYRNS LLHEFLEDWY
     NQEFLGSQCS FGDDRHLTNR VLSLGYATKY TARSKCLTET PTEYLRWLNQ QTRWSKSYFR
     EWLYNAMWFH KHHLWMTYEA VITGFFPFFL IATVIQLFYR GRIWNILLFL LTVQLVGLIK
     SSFASALRGN IVMVFMSLYS VLYMSSLLPA KMFAIATINK AGWGTSGRKT IVVNFIGLIP
     ITVWFTILLG GVCYTIWRET KKPFSESEKI VLAVGAILYA CYWVMLLTMY VSLVMKCGRR
     RKEPQHDLVL DV
//
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