ID B1Y1M4_LEPCP Unreviewed; 511 AA.
AC B1Y1M4;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:ACB35486.1};
GN OrderedLocusNames=Lcho_3228 {ECO:0000313|EMBL:ACB35486.1};
OS Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix
OS discophora (strain SP-6)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Leptothrix.
OX NCBI_TaxID=395495 {ECO:0000313|EMBL:ACB35486.1, ECO:0000313|Proteomes:UP000001693};
RN [1] {ECO:0000313|EMBL:ACB35486.1, ECO:0000313|Proteomes:UP000001693}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51168 / LMG 8142 / SP-6
RC {ECO:0000313|Proteomes:UP000001693};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Emerson D., Richardson P.;
RT "Complete sequence of Leptothrix cholodnii SP-6.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP001013; ACB35486.1; -; Genomic_DNA.
DR RefSeq; WP_012348233.1; NC_010524.1.
DR AlphaFoldDB; B1Y1M4; -.
DR STRING; 395495.Lcho_3228; -.
DR KEGG; lch:Lcho_3228; -.
DR eggNOG; COG0665; Bacteria.
DR HOGENOM; CLU_022247_1_0_4; -.
DR OrthoDB; 462203at2; -.
DR Proteomes; UP000001693; Chromosome.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001693}.
FT ACT_SITE 81
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 16..19
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 81
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 188
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 341
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 350
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 511 AA; 57304 MW; 485E93CAB6019A91 CRC64;
MSNPERHLRD IVIIGGGSAG WMAAAALSSA LSQRCRVTLV ESDEIGTVGV GEATIPPIRI
FNQTLGLDEA EFLKRTQGTF KLGIEFVDWA RLGQRYFHPF GPHGVQFDLS PQHQYWLRSR
GREGMPGIDE HSMAWVMASR GRFDRPSSDP RSVLSTFDYA YHFDATLYAR YLREVSEARG
VRRIEGQVVG VALRPTDGFV ASVRLADGRD IAGELFIDCS GFRGLLIEQT LHTGYEDWSH
WLPCDRAMAV PCSHPESPEG GELTPYTRST ARAAGWQWRI PLQHRIGNGH VYSSQFLDDD
EAAAVLLDNL DGAALAAPRA LRFTTGRRKQ FWNRNVVALG LASGFMEPLE STSLHLVQSG
ISRLLALFPD RDFDPLTAAE YNRIGVQEFE RIRDFLILHY KLTERDDAPL WRYCAAMPIP
DTLQYKIEHF RRYGRLVSEG MELFGNASWL SVHIGQLNWP QRHDPLVDLR DVDGDAVLAR
LRQAMVSAAH GLPGHADFIR RHCAARAACP A
//
